Abstract:
:The purpose of this study was to establish the proton NMR relaxation times of collapsed but otherwise normal lung tissue and to determine whether an inflammatory process within a collapsed lung can be detected by alterations in relaxation times. The lungs of three groups of rabbits were studied: group A (n = 7) had a sterile collapse of one lung for two days. The two other groups also had one lung collapsed, but with bacterial (group B, n = 6) or chemically induced (group C; n = 6) pneumonitis superimposed. The contralateral lung, which was acutely deflated at the time of thoracotomy, served as a control in each animal. T1, T2 and the total water content were measured on freshly excised lung samples. In group A, there was no significant difference in T1 (606 +/- 14* ms vs. 595 +/- 18 ms;* = SEM) or T2 (80.6 +/- 1.7 ms vs. 78.4 +/- 2.6 ms) between the collapsed and the control lung tissue. In each animal in groups B and C, T2 was longer in the collapsed lung with superimposed pneumonitis than in the control lung tissue (group B: 116.8 +/- 6.9 ms vs. 82.9 +/- 1.8 ms, P less than .001; group C: 120.5 +/- 5.9 ms vs. 86.0 +/- 1.5 ms, P less than .001). T1 changes were similar, but less marked. There was a linear relationship between the relaxation times and the total water content of the lung samples (T1:r = 0.87; T2:r = 0.91). It is concluded that proton NMR may have a potential in detecting disease such as inflammation in collapsed lung tissue based on differences in relaxation parameters compared with normal lung areas.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Huber DJ,Kobzik L,Melanson G,Adams DFdoi
10.1097/00004424-198508000-00004subject
Has Abstractpub_date
1985-08-01 00:00:00pages
460-4issue
5eissn
0020-9996issn
1536-0210journal_volume
20pub_type
杂志文章abstract:OBJECTIVES:The objectives of this study were to assess the feasibility of magnetic resonance cholangiography (MRC) using biliary-secreted gadoxetic acid at 7 T and to compare it with T2-weighted (w) MRC at 3 T. MATERIALS AND METHODS:Ten healthy volunteers were examined on a 7-T whole-body magnetic resonance system. T2...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000004
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vasoconstriction of the renal arteries is frequently considered as a crucial factor for radiocontrast-induced nephropathy. A direct effect of iodinated radiographic contrast medium (RCM) on vascular smooth muscle is supposed to be one component of the vascular response. We studied the effec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200208000-00005
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000431
更新日期:2018-04-01 00:00:00
abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197807000-00002
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVES:We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial in...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182718672
更新日期:2013-01-01 00:00:00
abstract::The authors reexamined a suspected difference in the effects of clinical information upon detection of nodules vs. more diverse lesions by directly incorporating classification specificity into detection ROC analysis. Categorical prompts, correct for specific abnormalities, led to detection superior to unprompted read...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198801000-00011
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:Detection of pulmonary metastases is still a challenging task for magnetic resonance imaging (MRI). It was the aim of this study to evaluate the potential of a free-breathing move-during-scan turbo inversion recovery magnitude sequence for the detection of pulmonary nodules. MATERIALS AND METHODS:The sensitivi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816901fa
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Nephrogenic systemic fibrosis (NSF) has been related to the use of gadolinium-based contrast agents (GBCAs) in patients undergoing dialysis. The Prospective Fibrose Nephrogénique Systémique study, a French prospective study supported by the French drug regulatory agency (Agence Nationale de Sécurité du Médic...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/RLI.0000000000000000
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine if voxel-based histogram analysis of intravoxel incoherent motion imaging (IVIM) parameters can differentiate various subtypes of renal tumors, including benign and malignant lesions. SUBJECTS AND METHODS:A total of 44 patients with renal tumors who underwent surgery a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000111
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS:In this institutional r...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000418
更新日期:2018-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied premenopausal, perimenopausal, and postmenopausal women to determine if ultrasound bone velocity (UBV) on proximal phalanges of women reflect bone changes related to gonadal status and age. METHODS:A total of 166 healthy women-64 postmenopausal women (mean age 58.7 +/- 9.4 ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199701000-00011
更新日期:1997-01-01 00:00:00
abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199204000-00008
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess quantitative ultra-high b-value (UHB) diffusion magnetic resonance imaging (MRI)-derived parameters in comparison to standard clinical apparent diffusion coefficient (SD-ADC-2b-1000, SD-ADC-2b-1500) for the prediction of clinically significant prostate cancer, defined as G...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000712
更新日期:2021-02-01 00:00:00
abstract::An isotopic radiation source 125I was investigated for use in soft tissue radiaography, with particular attention to possible use in mammography for mass screening. Film sensitivities, exposure rates, absorbed doeses, contrast and resolution were determined, and compared to conventional x-ray units. It was found that ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197509000-00007
更新日期:1975-09-01 00:00:00
abstract::We compared the damage resulting from intradermal injection of four commonly used radiographic contrast media in laboratory rats. Sixty percent meglumine diatrizoate (Reno M 60) and ioxaglate (Hexabrix) produced significantly more ulceration and crusting on gross inspection and more necrosis, edema, and hemorrhage on ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199005000-00006
更新日期:1990-05-01 00:00:00
abstract::Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199006000-00011
更新日期:1990-06-01 00:00:00
abstract:PURPOSE:To determine whether liver metastases conspicuity is improved at 80 kVp when compared with weighted average (WA) simulated 120 kVp data using dual source dual energy CT. METHODS:A total of 11 patients with 44 hypo-vascular liver metastases underwent contrast enhanced Dual Energy CT (DECT). In all cases the sub...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181dfda78
更新日期:2010-07-01 00:00:00
abstract::The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000507
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:To test the feasibility of combining inner-volume imaging (IVI) techniques with conventional multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) techniques for targeted-PROPELLER magnetic resonance imaging. MATERIALS AND METHODS:Perpendicular section-selective ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181a8b015
更新日期:2009-08-01 00:00:00
abstract::A silicone gel phantom material is described. It can be molded into any shape and it can contain internal cavities. The material is selfsealing allowing the cavities to be filled with liquids. A simple geometric phantom consisting of a rectangular solid with a single internal spherical cavity was fabricated and imaged...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198702000-00013
更新日期:1987-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES AND RATIONALE:Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199306000-00011
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear. OBJECTIVE:We investigated the factors ass...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000757
更新日期:2021-01-19 00:00:00
abstract::Recent experimental data underlies the role of hypoxic tubular injury in the pathophysiology of radiocontrast nephropathy. Although systemic transient hypoxemia, increased blood viscosity, and a leftward shift of the oxygen-hemoglobin dissociation curve may all contribute to intrarenal hypoxia, imbalance between oxyge...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199911000-00004
更新日期:1999-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared fro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199603000-00003
更新日期:1996-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the feasibility of mechanical thrombectomy in occluded hemodialysis access shunts by using a newly developed 5F pigtail rotation catheter. METHODS:Thrombosed hemodialysis access shunts were simulated by clotted bovine blood in silicone tubing (diameter 6 mm). After retrograde and a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199907000-00008
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:To test the technique and feasibility of translating tumor suspicious region maps in the prostate, obtained by multimodality, anatomic, and functional 3T magnetic resonance imaging (MRI) data to 32-channel coil, T2-weighted (T2-w), 3T MR images, for directing MR-guided biopsies. Furthermore, to evaluate the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31817d0506
更新日期:2008-10-01 00:00:00
abstract::The microangiographic anatomy of the cat's eye is presented. The characteristic vascular pattern of each of the three distinct circulations, retinal choroidal, and ciliary is described and illustrated. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197501000-00007
更新日期:1975-01-01 00:00:00
abstract::"Satisfaction of search" (SOS) refers to the effect in which a second lesion remains undetected after detection of another lesion on the same radiograph. The objective of this study was to clarify our understanding of SOS by relating it to total time of inspection and time intervals before, between, and after discover...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199107000-00003
更新日期:1991-07-01 00:00:00