Extravascular extravasation of radiographic contrast media. Effects of conventional and low-osmolar agents in the rat thigh.

Abstract:

:We compared the damage resulting from intradermal injection of four commonly used radiographic contrast media in laboratory rats. Sixty percent meglumine diatrizoate (Reno M 60) and ioxaglate (Hexabrix) produced significantly more ulceration and crusting on gross inspection and more necrosis, edema, and hemorrhage on histologic evaluation than iopamidol 300 (Isovue) or 0.9% (normal) saline. Thirty percent meglumine diatrizoate (Reno M Dip) had an intermediate toxicity, resulting in significantly more visible swelling and more microscopically detected hemorrhage than iopamidol or saline, but less ulceration/crusting and necrosis than Reno M 60 and ioxaglate. Since the three contrast agents of similar osmolality produced different degrees of tissue damage, our results suggest that factors other than high osmolality are partially responsible for determining the severity of injuries from extravasated contrast media.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Cohan RH,Leder RA,Bolick D,Herzberg AJ,Hedlund LW,Wheeler CT,Helms MJ,Dunnick NR

doi

10.1097/00004424-199005000-00006

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

504-10

issue

5

eissn

0020-9996

issn

1536-0210

journal_volume

25

pub_type

杂志文章
  • The role of catheters and guidewires in the production of angiographic thromboembolic complications.

    abstract::Thromboembolic complications occurring during angiography may result from a number of different causes. Catheters and guidewires can interact with blood to form thrombi; this tendency is related to wall defects and the chemical composition and structural characteristics of the catheters and guidewires. Nonthrombic sou...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-198811002-00009

    authors: Kido DK,King PD,Manzione JV,Simon JH

    更新日期:1988-11-01 00:00:00

  • Magnetic resonance imaging using gadolinium labeled monoclonal antibody.

    abstract::Gadolinium was attached to antibodies and tested in vitro and in vivo for its effect on proton relaxation enhancement. Using the cyclic anhydride method, diethylenetriaminepentaacetic acid (DTPA) was attached to albumin, IgG and anti-CEA monoclonal antibody. Gadolinium (Gd) was then chelated to the protein complexes f...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198510000-00008

    authors: Unger EC,Totty WG,Neufeld DM,Otsuka FL,Murphy WA,Welch MS,Connett JM,Philpott GW

    更新日期:1985-10-01 00:00:00

  • Attenuation correction for flexible magnetic resonance coils in combined magnetic resonance/positron emission tomography imaging.

    abstract:INTRODUCTION:Attenuation correction for magnetic resonance (MR) coils is a new challenge that came about with the development of combined MR and positron emission tomography (PET) imaging. This task is difficult because such coils are not directly visible on either PET or MR acquisitions with current combined scanners ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182a530f8

    authors: Eldib M,Bini J,Calcagno C,Robson PM,Mani V,Fayad ZA

    更新日期:2014-02-01 00:00:00

  • Iopamidol as a gastrointestinal contrast agent. Lack of peritoneal reactivity.

    abstract::The ideal contrast agent in patients suspected of having gastrointestinal perforation is an iso-osmolar, or nearly iso-osmolar substance, that causes no peritoneal reaction. Iopamidol is a nonionic water-soluble contrast medium that may be considered in such situations. Intraperitoneal injections of ionic and nonionic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199002000-00008

    authors: Ferrante SL,Schreiman JS,Rouse JW,Rysavy JA,Cheng SC,Frick MP

    更新日期:1990-02-01 00:00:00

  • Advances in magnetic resonance (2006).

    abstract::Advances in the field of magnetic resonance (MR) as it pertains to clinical diagnostic radiology are examined in this review on the basis of publications in Investigative Radiology over the past 2 years (2005-2006). The articles published during that timeframe are discussed, organizationally wise, by anatomic region w...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.rli.0000250461.03245.5c

    authors: Runge VM

    更新日期:2006-12-01 00:00:00

  • Increased ablation zones using a cryo-based internally cooled bipolar RF applicator in ex vivo bovine liver.

    abstract:PURPOSE:To evaluate the feasibility of ex vivo ablation implementing a cryo-based internally cooled bipolar radiofrequency (RF) applicator and to determine the influence of power and gas pressure on the size and shape of the resulting ablation zones. MATERIALS AND METHODS:Two hundred twenty-five ablations were perform...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181b66d11

    authors: Rempp H,Voigtländer M,Clasen S,Kempf S,Neugebauer A,Schraml C,Schmidt D,Claussen CD,Enderle MD,Goldberg SN,Pereira PL

    更新日期:2009-12-01 00:00:00

  • Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the extent to which various commercially available gadolinium-containing contrast-enhancing (CE) agents can interfere with the measurement of calcium levels by currently used laboratory methods, suggesting (spurious) hypocalcemia or hypercalcemia with a potential ris...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000170447.45577.5e

    authors: Löwe A,Balzer T,Hirt U

    更新日期:2005-08-01 00:00:00

  • Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver.

    abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31805f2682

    authors: Watanabe R,Matsumura M,Munemasa T,Fujimaki M,Suematsu M

    更新日期:2007-09-01 00:00:00

  • Technical feasibility and performance studies of a 0.009-inch nitinol microguidewire for potential neuroendovascular applications.

    abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199704000-00008

    authors: Putman CM,Chaloupka JC,Kailasnath P,Alderman J

    更新日期:1997-04-01 00:00:00

  • Pharmacokinetics and safety of gadobutrol-enhanced magnetic resonance imaging in pediatric patients.

    abstract:OBJECTIVES:This clinical study investigated the pharmacokinetics and safety of gadobutrol, a magnetic resonance (MR) imaging extracellular contrast agent, in pediatric patients aged 2 to 17 years. MATERIALS AND METHODS:In this open-label, multicenter study, patients scheduled for routine contrast-enhanced MR imaging o...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181bfe2d2

    authors: Hahn G,Sorge I,Gruhn B,Glutig K,Hirsch W,Bhargava R,Furtner J,Born M,Schröder C,Ahlström H,Kaiser S,Moritz JD,Kunze CW,Shroff M,Stokland E,Trnkova ZJ,Schultze-Mosgau M,Reif S,Bacher-Stier C,Mentzel HJ

    更新日期:2009-12-01 00:00:00

  • Hemodynamic effect of iodinated high-viscosity contrast medium in the rat kidney: a diffusion-weighted MRI feasibility study.

    abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200011000-00001

    authors: Laissy JP,Menegazzo D,Dumont E,Piekarski JD,Karila-Cohen P,Chillon S,Schouman-Claeys E

    更新日期:2000-11-01 00:00:00

  • AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy.

    abstract:RATIONALE AND OBJECTIVES:The authors synthesized and tested a novel hydrogel system proposed for use in extra- and intravascular radiologic interventions, such as chemoembolizations and embolizations, and as a vehicle for sustained drug release. MATERIALS:The material was specifically designed to meet the prerequisite...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199312000-00001

    authors: Weissleder R,Bogdanov A,Frank H,Nossiff N,Bogdanova A,Schaffer BK,Brady T,Wittenberg J

    更新日期:1993-12-01 00:00:00

  • Pulmonary density distribution in experimental noncardiac canine pulmonary edema evaluated by computed transmission tomography.

    abstract::We evaluated the density distribution (anterior-posterior) of the right lung in 19 acutely anesthetized supine dogs using computed transmission tomography (CTT). Eleven dogs served as controls, and eight received 0.12 cc/kg of intravenously administered oleic acid. The latter were sequentially imaged over 1 hour. Nine...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Slutsky RA,Long S,Peck WW,Higgins CB,Mattrey R

    更新日期:1984-05-01 00:00:00

  • A preliminary study of MRI quantification of simulated calcified pulmonary nodules.

    abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198711000-00001

    authors: Gamsu G,de Geer G,Cann C,Müller N,Brito A

    更新日期:1987-11-01 00:00:00

  • Acute systemic and renal hemodynamic effects of meglumine/sodium diatrizoate 76% and iopamidol in euvolemic and dehydrated dogs.

    abstract::We examined the acute systemic and renal hemodynamic effects of intravenous meglumine/sodium diatrizoate-76% and iopamidol in euvolemic and dehydrated dogs. The physiologic responses were compared with acute changes in the level of an endogenous heparin-like material (EHM). One of eight dehydrated dogs receiving diatr...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198610000-00005

    authors: Katzberg RW,Morris TW,Lasser EC,DiMarco PL,Merguerian PA,Ventura JA,Pabico RC,McKenna BA

    更新日期:1986-10-01 00:00:00

  • Depiction of reperfused myocardial infarction using contrast-enhanced spin echo and gradient echo magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:The authors used gadolinium (Gd) chelate as a T1, T2, and T2* enhancing agent in reperfused myocardial infarction to compare the appearance of reperfused myocardial infarction on spin echo and gradient echo magnetic resonance (MR) sequences. METHODS:Rats (n = 28) were subjected to reperfused m...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199807000-00002

    authors: Geschwind JF,Saeed M,Wendland MF,Higgins CB

    更新日期:1998-07-01 00:00:00

  • A method for the study of regional ischemic dysfunction in the intact dog. Permanent endocardial markers and the pressure-length loop.

    abstract::A radiographic method for use in the closed-chest dog is described which allows the quantitation of segmental mechanical performance. Previous work has shown that the area of the pressure-length loop (an approximation of a stress-strain integral) is a useful measure of the mechanical work performed by a segment of myo...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197611000-00010

    authors: Ringertz HG,Carlsson E,Tyberg JV

    更新日期:1976-11-01 00:00:00

  • Clinical experience with saralasin infusion in hypertensive patients.

    abstract::Renal arteriography gives a reliable anatomic delineation of the renal vasculature. However, the presence of renal arterial disease does not determine the physiologic significance of the lesion. The intravenous infusion of saralasin, a specific angiotensin II antagonist, has been investigated as a method for identify...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197711000-00006

    authors: Tegtmeyer CJ,Latour EA,Vaughan ED Jr,Ayers CR,Carey RM,Wellons HA Jr

    更新日期:1977-11-01 00:00:00

  • Imaging of complex NMR spectra.

    abstract::The Point Spread Function (PSF) in NMR imaging is the result of both the line broadening due to magnet field inhomogeneity and the intrinsic spectrum of the nucleus at resonance. In the case of proton imaging, the line broadening dominates the small chemical shifts and the spectral lines are not resolved. This is not ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198503000-00016

    authors: Harrison CG,Adams DF,Kramer PB

    更新日期:1985-03-01 00:00:00

  • Pancreatic Steatosis Is Associated With Impaired Exocrine Pancreatic Function.

    abstract:OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000554

    authors: Kromrey ML,Friedrich N,Hoffmann RT,Bülow R,Völzke H,Weiss FU,Lerch MM,Motosugi U,Kühn JP

    更新日期:2019-07-01 00:00:00

  • Breast stereotactic core biopsy washings: abundant cell samples from clinically occult lesions for flow cytometric DNA analysis.

    abstract:RATIONALE AND OBJECTIVES:The object of this study was to determine by flow cytometry the cellular and DNA content of the washings of core biopsy samples and needles obtained during stereotactic core biopsies of clinically occult suspicious lesions. METHODS:Fourteen-gauge core multipass biopsy inner-needle saline washi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199801000-00008

    authors: Stomper PC,Budnick RM,Stewart CC

    更新日期:1998-01-01 00:00:00

  • Effect of inspiratory and expiratory breathhold on pulmonary perfusion: assessment by pulmonary perfusion magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:The effect of breathholding on pulmonary perfusion remains largely unknown. The aim of this study was to assess the effect of inspiratory and expiratory breathhold on pulmonary perfusion using quantitative pulmonary perfusion magnetic resonance imaging (MRI). METHODS AND RESULTS:Nine healthy v...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000149252.42679.78

    authors: Fink C,Ley S,Risse F,Eichinger M,Zaporozhan J,Buhmann R,Puderbach M,Plathow C,Kauczor HU

    更新日期:2005-02-01 00:00:00

  • Comparison of Routine Brain Imaging at 3 T and 7 T.

    abstract:OBJECTIVE:The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], image quality, diagnostic confidence) from a standard brain magnetic resonance imaging examination encompassing common neurological disorders such as demyelinating dis...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000256

    authors: Springer E,Dymerska B,Cardoso PL,Robinson SD,Weisstanner C,Wiest R,Schmitt B,Trattnig S

    更新日期:2016-08-01 00:00:00

  • Incompatibility of water-soluble contrast media and intravascular pharmacologic agents. An in vitro study.

    abstract::In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with dia...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199201000-00008

    authors: Kim SH,Lee HK,Han MC

    更新日期:1992-01-01 00:00:00

  • Effect of Age on High T1 Signal Intensity of the Dentate Nucleus and Globus Pallidus in a Large Population Exposed to Gadodiamide.

    abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000431

    authors: Quattrocchi CC,Errante Y,Mallio CA,Marinelli L,LoVullo G,Giannotti G,Della Sala SW,van der Molen AJ,Beomonte Zobel B

    更新日期:2018-04-01 00:00:00

  • Patient choice and nonionic contrast media.

    abstract:RATIONALE AND OBJECTIVES:Because of the greatly increased cost of nonionic, low-osmolar contrast material, some practitioners reserve its use for patients at high risk for an adverse contrast reaction. The authors attempt to evaluate the proportion of low-risk outpatients--when offered a choice between the more expensi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199304000-00008

    authors: Hopper KD,Matthews YL

    更新日期:1993-04-01 00:00:00

  • Magnetic resonance angiography. Application to the peripheral circulation.

    abstract::Magnetic resonance angiography (MRA) for application in the musculoskeletal system is progressing at a rapid pace. The clinical role of this new technique is still being developed, although a number of uses have already become well recognized, and MRA is diffusing into clinical practice. This article describes the bas...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199212002-00014

    authors: Harms SE,Flamig DP

    更新日期:1992-12-01 00:00:00

  • CT Dosimetry: What Has Been Achieved and What Remains to Be Done.

    abstract::Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000727

    authors: Damilakis J

    更新日期:2021-01-01 00:00:00

  • A comparison of iopromide with iopamidol and iohexol for contrast-enhanced computed tomography.

    abstract:RATIONALE AND OBJECTIVES:Iopromide is a new monomeric, nonionic contrast agent that exhibits low osmolality and low viscosity in high concentration in aqueous solutions. Double-blind, randomized clinical trials have established the efficacy, safety, and tolerance of iopromide for excretory urography, coronary angiograp...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199405001-00015

    authors: Goldberg SN,Abrahams J,Drayer BP,Golding S,Bernardino M,Brunetti J

    更新日期:1994-05-01 00:00:00

  • New contrast media designed for x-ray energy subtraction imaging in digital mammography.

    abstract:RATIONALE AND OBJECTIVES:In contrast-enhanced dual-energy subtraction imaging 2 images acquired postcontrast media administration at different energies are subtracted to highlight structures hidden in the absence of contrast media. X-ray spectra of the newly developed digital full-field mammography units (GE Senographe...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.RLI.0000077124.24140.bd

    authors: Lawaczeck R,Diekmann F,Diekmann S,Hamm B,Bick U,Press WR,Schirmer H,Schön K,Weinmann HJ

    更新日期:2003-09-01 00:00:00