Clinical experience with saralasin infusion in hypertensive patients.

Abstract:

:Renal arteriography gives a reliable anatomic delineation of the renal vasculature. However, the presence of renal arterial disease does not determine the physiologic significance of the lesion. The intravenous infusion of saralasin, a specific angiotensin II antagonist, has been investigated as a method for identifying patients with hypertension dependent upon excessive angiotensin II activity. Correlations between the blood pressure response to saralasin infusion, peripheral and differential renal vein plasma renin levels and renal angiography have been obtained in 35 hypertensive patients. The results suggest that a hypotensive response to saralasin infusion provides an adjunct to renin determinations for recognizing angiotensinogenic renovascular hypertension. However, false negative responses to saralasin occur. The reasons for these negative responses need to be determined before saralasin infusion can be employed as the sole screening test for renovascular hypertension.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Tegtmeyer CJ,Latour EA,Vaughan ED Jr,Ayers CR,Carey RM,Wellons HA Jr

doi

10.1097/00004424-197711000-00006

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

496-504

issue

6

eissn

0020-9996

issn

1536-0210

journal_volume

12

pub_type

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