AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy.

Abstract:

RATIONALE AND OBJECTIVES:The authors synthesized and tested a novel hydrogel system proposed for use in extra- and intravascular radiologic interventions, such as chemoembolizations and embolizations, and as a vehicle for sustained drug release. MATERIALS:The material was specifically designed to meet the prerequisites of biodegradation, biocompatibility, low immunogenicity, low toxicity, and easy use. The material consists of a protein backbone cross-linked with activated bifunctional polyethyleneglycol (PEG) derivatives (PEG-derivatized hydrogel, [PDH]) to which are attached therapeutic (e.g., doxorubicin, a chemotherapeutic agent = PDH-dx) or diagnostic labels (e.g. Gd-DTPA). RESULTS:PDH-dx effectively reduced the risk of local tumor recurrence in a rat model when implanted locally after surgical tumor removal. After administration, PDH is degraded by proteases release from macrophages; implantations of 1 mL samples into paraspinal muscles of rats were completely absorbed within 4 weeks and its constituents were metabolized. Antibody titers (total Ig response) against the PDH were not detectable 1 week after implantation, whereas protein control substances elicited a strong response. CONCLUSIONS:PDH and its derivatives are relatively nontoxic, biodegradable materials for use in radiologic interventions and as a vehicle for sustained drug release.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Weissleder R,Bogdanov A,Frank H,Nossiff N,Bogdanova A,Schaffer BK,Brady T,Wittenberg J

doi

10.1097/00004424-199312000-00001

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1083-9

issue

12

eissn

0020-9996

issn

1536-0210

journal_volume

28

pub_type

杂志文章
  • Influences on the rate of absorption of the cholecystographic contrast medium iosumetic acid in man.

    abstract::Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197607000-00009

    authors: Speck U,Clauss W,Blumenbach L,Albrecht A

    更新日期:1976-07-01 00:00:00

  • Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract.

    abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-197811000-00008

    authors: Johansen JG

    更新日期:1978-11-01 00:00:00

  • Applications of voxel shifting in magnetic resonance imaging.

    abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199012000-00006

    authors: Kramer D,Li A,Simovsky I,Hawryszko C,Hale J,Kaufman L

    更新日期:1990-12-01 00:00:00

  • The current status of total joint replacement.

    abstract::The last two decades have witnessed tremendous strides in the evolution of acceptable and successful methods of prosthetic replacement for the arthritic joint. By and large, these techniques are predictable and durable, though not always to the complete satisfaction of the patient and surgeon. Despite the recent empha...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199001000-00022

    authors: Volz RG,Benjamin JB

    更新日期:1990-01-01 00:00:00

  • Magnetic resonance imaging using gadolinium labeled monoclonal antibody.

    abstract::Gadolinium was attached to antibodies and tested in vitro and in vivo for its effect on proton relaxation enhancement. Using the cyclic anhydride method, diethylenetriaminepentaacetic acid (DTPA) was attached to albumin, IgG and anti-CEA monoclonal antibody. Gadolinium (Gd) was then chelated to the protein complexes f...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198510000-00008

    authors: Unger EC,Totty WG,Neufeld DM,Otsuka FL,Murphy WA,Welch MS,Connett JM,Philpott GW

    更新日期:1985-10-01 00:00:00

  • Subtype differentiation of renal tumors using voxel-based histogram analysis of intravoxel incoherent motion parameters.

    abstract:OBJECTIVES:The aim of this study was to determine if voxel-based histogram analysis of intravoxel incoherent motion imaging (IVIM) parameters can differentiate various subtypes of renal tumors, including benign and malignant lesions. SUBJECTS AND METHODS:A total of 44 patients with renal tumors who underwent surgery a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000111

    authors: Gaing B,Sigmund EE,Huang WC,Babb JS,Parikh NS,Stoffel D,Chandarana H

    更新日期:2015-03-01 00:00:00

  • Lactate accumulation in ischemic- and anoxic-isolated rat hearts assessed by H-1 spectroscopy.

    abstract::Proton magnetic resonance (MR) spectroscopy with homonuclear editing was used to assess lactate accumulation in ischemic and anoxic hearts perfused according to the Langendorff method. An increase in the lactate signal was observed after 5 minutes of ischemia and after 10 to 20 minutes of anoxia. This study demonstrat...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198708000-00004

    authors: Richards TL,Terrier F,Sievers RE,Lipton MJ,Moseley ME,Higgins CB

    更新日期:1987-08-01 00:00:00

  • 3.0 Tesla high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) of the pulmonary circulation: initial experience with a 32-channel phased array coil using a high relaxivity contrast agent.

    abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000261937.77365.6a

    authors: Nael K,Fenchel M,Krishnam M,Finn JP,Laub G,Ruehm SG

    更新日期:2007-06-01 00:00:00

  • Incidence and methods of diagnosis of musculoskeletal injuries incurred in Operations Desert Shield and Desert Storm.

    abstract:RATIONALE AND OBJECTIVES:The authors studied the incidence and distribution of orthopedic injuries sustained in Operation Desert Shield and Desert Storm by evaluating whether existing diagnostic imaging modalities were sufficient to diagnose the types of musculoskeletal injuries incurred. The authors also sought to det...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199703000-00006

    authors: Truax AL,Chandnani VP,Chacko AK,Gonzalez DM

    更新日期:1997-03-01 00:00:00

  • Quantification of roughness of calcific deposits in computed tomography scans of human coronary arteries.

    abstract:OBJECTIVES:The incidence of coronary artery disease has been shown to be greater in patients with calcific deposits than in those without. It has been suggested that the pattern of distribution of coronary calcific deposits within coronary arteries is of greater predictive value for acute coronary events than the overa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3180cc2041

    authors: Wilner WT,Mazraeshahi RM,Aboshady I,Bodmann BG,Papadakis M,Kouri D,Conyers JL,Cherukuri P,Vela D,Gladish G,Gavish L,Cody DD,Frazier L,Lukovenkov S,Madjid M,Zarrabi A,Ahmed A,Willerson JT,Casscells SW,Gertz SD

    更新日期:2007-11-01 00:00:00

  • Characterization of ultrasmall magnetite [correction of paramagnetic magnetite] particles as superparamagnetic contrast agents in MRI.

    abstract:RATIONALE AND OBJECTIVES:Very small dextran-coated magnetite particles were developed. These particles can be used either as immunospecific contrast agents for MRI by coupling to antibodies or as an interstitial contrast agent. METHODS:The particles were synthesized from iron chloride/dextran solutions. Size was evalu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200009000-00006

    authors: Grimm J,Karger N,Lüsse S,Winoto-Morbach S,Krisch B,Müller-Hülsbeck S,Heller M

    更新日期:2000-09-01 00:00:00

  • Regional ejection fractions in patients with patent and thrombosed grafts after coronary artery vein bypass surgery.

    abstract::Twenty-six patients who had received 43 grafts were studied before and after coronary artery vein bypass surgery. Cine ventriculograms taken in the right anterior oblique projection were analyzed and regional ejection fractions calculated. Single and multiple grafts were considered separately as were thrombosed and pa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197705000-00001

    authors: Martin EC,Wixson D,Baltaxe HA

    更新日期:1977-05-01 00:00:00

  • Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model.

    abstract:OBJECTIVE:The purpose of this study was to assess the ability of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold standard. MATERIALS AND METHODS...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181f5e101

    authors: Artz NS,Wentland AL,Sadowski EA,Djamali A,Grist TM,Seo S,Fain SB

    更新日期:2011-02-01 00:00:00

  • Pharmacokinetics and safety of iomeprol in healthy volunteers and in patients with renal impairment or end-stage renal disease requiring hemodialysis.

    abstract:RATIONALE AND OBJECTIVES:To present the results of two studies conducted to evaluate the pharmacokinetics and safety of iomeprol in healthy volunteers and in patients with various degrees of renal impairment. METHODS:In these two open-label, single-dose, phase I studies, a 50-mL dose of iomeprol 400 was administered i...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-200106000-00002

    authors: Lorusso V,Taroni P,Alvino S,Spinazzi A

    更新日期:2001-06-01 00:00:00

  • Comparison of observer performance reading from a video CRT vs. reading from film.

    abstract::The developing trend for all medical images to be in digital form raises an important question: should diagnostic interpretations be made directly from a CRT or from some form of hard copy recording of the CRT? This question was studied by having two observers read a series of digital images of the thyroid including b...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198305000-00015

    authors: Keyes JW Jr,Kline RC,Resinger WW,Rose EA,Koral KF,Rogers WL

    更新日期:1983-05-01 00:00:00

  • Quantitative evaluation of perfusion and permeability of peripheral tumors using contrast-enhanced computed tomography.

    abstract:RATIONALE AND OBJECTIVES:Our purpose was to validate contrast-enhanced computed tomography (CECT)-derived quantitative measures of perfusion and permeability against gold standard techniques of fluorescent microspheres and Evan's Blue dye, respectively. MATERIALS AND METHODS:Normal and tumor-bearing (R3230AC) Fischer ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01rli.0000124456.82985.35

    authors: Pollard RE,Garcia TC,Stieger SM,Ferrara KW,Sadlowski AR,Wisner ER

    更新日期:2004-06-01 00:00:00

  • Role of iodinated contrast material in the evaluation of myocardial infarction by computerized transmission tomography.

    abstract::In vivo and in vitro studies have shown that areas of myocardial infarctions can be delineated on CT scans after intravenous administration of iodinated contrast material to dogs with experimental myocardial infarctions. Within the first minute after intravenous administration of contrast material (initial myocardial ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198011001-00039

    authors: Higgins CB,Siemers PT,Newell JD,Schmidt W

    更新日期:1980-11-01 00:00:00

  • Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.

    abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000618

    authors: Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

    更新日期:2020-03-01 00:00:00

  • The role of catheters and guidewires in the production of angiographic thromboembolic complications.

    abstract::Thromboembolic complications occurring during angiography may result from a number of different causes. Catheters and guidewires can interact with blood to form thrombi; this tendency is related to wall defects and the chemical composition and structural characteristics of the catheters and guidewires. Nonthrombic sou...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-198811002-00009

    authors: Kido DK,King PD,Manzione JV,Simon JH

    更新日期:1988-11-01 00:00:00

  • Selective catheterization for magnification angiography of internal spermatic and proper hepatic arteries in rabbits.

    abstract::A method is presented for selective catheterization and filming of the small internal spermatic and proper hepatic arteries in rabbits. The angiograms thus obtained afford clear delineation of the vessels and their branches and can enhance radiographic investigation of a variety of experimental disease models. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197705000-00009

    authors: Young S,Hollenberg NK

    更新日期:1977-05-01 00:00:00

  • Systemic absorption of gallbladder sclerosing agents in the rabbit. A preliminary study.

    abstract::The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 mg/dl and of tetracycline was 4.6 micrograms/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198605000-00005

    authors: Remley KB,Cubberley DA,Watanabe AS,Nelson JA,Colby TV

    更新日期:1986-05-01 00:00:00

  • New contrast media designed for x-ray energy subtraction imaging in digital mammography.

    abstract:RATIONALE AND OBJECTIVES:In contrast-enhanced dual-energy subtraction imaging 2 images acquired postcontrast media administration at different energies are subtracted to highlight structures hidden in the absence of contrast media. X-ray spectra of the newly developed digital full-field mammography units (GE Senographe...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.RLI.0000077124.24140.bd

    authors: Lawaczeck R,Diekmann F,Diekmann S,Hamm B,Bick U,Press WR,Schirmer H,Schön K,Weinmann HJ

    更新日期:2003-09-01 00:00:00

  • Comparison of Power Versus Manual Injection in Bolus Shape and Image Quality on Contrast-Enhanced Magnetic Resonance Angiography: An Experimental Study in a Swine Model.

    abstract:OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000383

    authors: Tsuboyama T,Jost G,Pietsch H,Tomiyama N

    更新日期:2017-09-01 00:00:00

  • The importance of nuclear magnetic relaxation dispersion (NMRD) profiles in MRI contrast media development.

    abstract::Observation of the relaxivity of MRI contrast media over a wide range of magnetic fields is not only necessary for predicting their efficiency at any field but also compulsory for understanding and improving their mechanisms of action. The best experimental approach to this problem is the field cycling method, which a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198809001-00047

    authors: Muller RN,Vander Elst L,Rinck PA,Vallet P,Maton F,Fischer H,Roch A,Van Haverbeke Y

    更新日期:1988-09-01 00:00:00

  • Magnetic resonance imaging contrast enhancement of brain tumors at 3 tesla versus 1.5 tesla.

    abstract:RATIONALE AND OBJECTIVES:To compare the diagnostic efficacy of a standard dose of MRI contrast agent in the evaluation of primary brain tumors and metastases using a high-field 3 tesla MR unit versus a 1.5 tesla MR unit. METHODS:Sixteen patients with brain tumors were examined at both field strengths using identical a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200203000-00003

    authors: Nöbauer-Huhmann IM,Ba-Ssalamah A,Mlynarik V,Barth M,Schöggl A,Heimberger K,Matula C,Fog A,Kaider A,Trattnig S

    更新日期:2002-03-01 00:00:00

  • Characteristics of magnetic resonance sequences used for imaging silicone gel, saline, and gel-saline implants at low field strengths.

    abstract:RATIONALE AND OBJECTIVES:Low-field magnetic resonance imaging (MRI) evaluation of breast implants is described, with emphasis on the capabilities provided by different imaging sequences. METHODS:Open architecture MR images using a .064-T permanent magnet and three-dimensional Fourier transform and inversion recovery s...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199408000-00009

    authors: Frankel S,Occhipinti K,Kaufman L,Kramer D,Carlson J,Mineyev M,Friedenthal R

    更新日期:1994-08-01 00:00:00

  • Evaluation of the prostate imaging reporting and data system for the detection of prostate cancer by the results of targeted biopsy of the prostate.

    abstract:PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000030

    authors: Baur AD,Maxeiner A,Franiel T,Kilic E,Huppertz A,Schwenke C,Hamm B,Durmus T

    更新日期:2014-06-01 00:00:00

  • The effects of ioxaglate 320, iohexol 350, and iopamidol 370 on erythrocyte aggregation.

    abstract::The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199108000-00009

    authors: Hayes R,Mahon T,Masterson J,Owens A

    更新日期:1991-08-01 00:00:00

  • Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?

    abstract:RATIONALE AND OBJECTIVES:To compare trabecular bone structure measures obtained in magnetic resonance images of the distal radius and the calcaneus as well as computed tomographic images of the spine versus bone mineral density (BMD) of the spine and the calcaneus in the prediction of osteoporotic spine fracture status...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000129154.50654.4e

    authors: Link TM,Bauer J,Kollstedt A,Stumpf I,Hudelmaier M,Settles M,Majumdar S,Lochmüller EM,Eckstein F

    更新日期:2004-08-01 00:00:00

  • Curriculum for musculoskeletal radiology.

    abstract::Although general suggestions have been made regarding a radiology residency curriculum, no specific list of entities has been offered. Over the past ten years, we have developed a resident-run morning conference in musculoskeletal radiology that is supervised by faculty and covers a specific curriculum. We offer our c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199111000-00019

    authors: Renfrew DL,el-Khoury GY,Moore TE,Kathol MH,Whitten CG,Walker CW,Fraser-Hill MA

    更新日期:1991-11-01 00:00:00