Quantitative evaluation of perfusion and permeability of peripheral tumors using contrast-enhanced computed tomography.

Abstract:

RATIONALE AND OBJECTIVES:Our purpose was to validate contrast-enhanced computed tomography (CECT)-derived quantitative measures of perfusion and permeability against gold standard techniques of fluorescent microspheres and Evan's Blue dye, respectively. MATERIALS AND METHODS:Normal and tumor-bearing (R3230AC) Fischer 344 rats were used. CECT perfusion measurements of normal and tumor tissue were compared with quantitative fluorescent microsphere perfusion measures. CECT permeability measurements from tumors were compared with semiquantitative Evan's Blue Dye permeability estimates. CT images were obtained precontrast and an imaging plane was selected. Serial, stationary images were obtained every 2 seconds for 2 minutes after intravenous bolus of iodinated contrast. Permeability and perfusion were measured by applying Patlak analysis to time-density data from normal tissue or tumor and femoral artery. RESULTS:There was good correlation between fluorescent microsphere and CECT measurements of perfusion (r2 = 0.681, P < 0.001) and between Evan's Blue Dye and CECT measurements of permeability (r2 = 0.873, P = 0.0007). CONCLUSIONS:CECT provides useful, quantifiable measures of perfusion and permeability in peripheral tumors.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Pollard RE,Garcia TC,Stieger SM,Ferrara KW,Sadlowski AR,Wisner ER

doi

10.1097/01rli.0000124456.82985.35

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

340-9

issue

6

eissn

0020-9996

issn

1536-0210

pii

00004424-200406000-00004

journal_volume

39

pub_type

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