Abstract:
RATIONALE AND OBJECTIVES:The basic characteristics of BR1, a novel echo contrast agent based on stabilized sulfur hexafluoride (SF6) microbubbles have been evaluated. METHODS:The authors determined the physicochemical properties (bubble concentration, bubble size distribution, resistance to pressure, and stability) and the acoustic properties (backscatter and attenuation coefficients) of BR1. The diagnostic value of BR1 was evaluated further in minipigs. Left heart images were recorded before and after injection of different doses of BR1. RESULTS:BR1 is formulated as a lyophilized product, which after addition of saline, provides a suspension containing 2 x 10(8) SF6 microbubbles/mL with a number mean diameter of 2.5 microns. More than 90% of the bubbles are below 8 microns. The use of SF6 rather than air provides an improved resistance to pressure increases such as the ones occuring in the left heart during systole. After reconstitution, the echogenicity and the bubble characteristics are unchanged for more than 8 hours. The high echogenicity remains almost constant over the entire medical frequency range (1-10 MHz). BR1 injections in animals resulted in a homogenous, dose-dependent opacification of the left heart. CONCLUSIONS:Considering its high echogenicity, outstanding stability, and resistance to pressure changes, BR1 is a very promising ultrasound contrast agent.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Schneider M,Arditi M,Barrau MB,Brochot J,Broillet A,Ventrone R,Yan Fdoi
10.1097/00004424-199508000-00001subject
Has Abstractpub_date
1995-08-01 00:00:00pages
451-7issue
8eissn
0020-9996issn
1536-0210journal_volume
30pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The effect of breathholding on pulmonary perfusion remains largely unknown. The aim of this study was to assess the effect of inspiratory and expiratory breathhold on pulmonary perfusion using quantitative pulmonary perfusion magnetic resonance imaging (MRI). METHODS AND RESULTS:Nine healthy v...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000149252.42679.78
更新日期:2005-02-01 00:00:00
abstract::Using real-time ultrasound, the motions of the tongue, hyoid bone, and larynx were monitored and timed during swallowing in ten normal subjects. A well-defined propulsive wave of the tongue was observed during swallowing a 5-cc water bolus. The body of the hyoid bone was identified on the ultrasound scan as a high ech...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS:Twenty patients with no cardiac ab...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181994a73
更新日期:2009-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Tools for monitoring modern target-specific antiangiogenic and antivascular therapies are highly desirable because treatment strategies are time consuming, expensive, and yet sometimes ineffective. Therefore, the aim of this experimental study was to evaluate the predictive value of steady-stat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3180d5cbd9
更新日期:2007-12-01 00:00:00
abstract::A double-blind randomized study of ten patients compared Hexabrix 32% to Renografin-60 in TMJ arthrography. Equivalent volumes of contrast material were injected under fluoroscopic observation, with film quality and patient subjective response graded independently by three radiologists. In immediate arthrogram quality...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00032
更新日期:1984-11-01 00:00:00
abstract::Simultaneous inflation of two balloons may be necessary for balloon dilation valvuloplasty in patients with a large annulus. We examined the cardiovascular effects of dilating the pulmonary annulus with two balloons in 18 normal dogs using pulsed Doppler ultrasound and gross and microscopic examination. When the ratio...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198808000-00005
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) who have received gadopentetate dimeglumine. MATERIALS AND METHODS:We retrospectively studied all patients who underwent contrast-enhanced magnetic resonance imagings (CE-MRIs) between January 1, ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31819343ba
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the effectiveness of a model-based iterative reconstruction (MBIR) in improving image quality and diagnostic performance of ultralow-dose computed tomography (ULDCT) of the lung. MATERIALS AND METHODS:The institutional review board approved this study, and all patients pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182562a89
更新日期:2012-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vasoconstriction of the renal arteries is frequently considered as a crucial factor for radiocontrast-induced nephropathy. A direct effect of iodinated radiographic contrast medium (RCM) on vascular smooth muscle is supposed to be one component of the vascular response. We studied the effec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200208000-00005
更新日期:2002-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared fro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199603000-00003
更新日期:1996-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Iopromide is a new monomeric, nonionic contrast agent that exhibits low osmolality and low viscosity in high concentration in aqueous solutions. Double-blind, randomized clinical trials have established the efficacy, safety, and tolerance of iopromide for excretory urography, coronary angiograp...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199405001-00015
更新日期:1994-05-01 00:00:00
abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00
abstract::Three facets of dual-energy quantitative computed tomography are studied: (1) the algorithm for postprocessing data (the methods of Cann, Laval-Jeantet et al, Goodsitt et al [two methods], and Nickoloff et al); (2) the influence of choice of tissue-equivalent materials for calibration; and (3) the difference between c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199008000-00003
更新日期:1990-08-01 00:00:00
abstract:PURPOSE:To prospectively determine the accuracy of 1.5 Tesla (T) and 3 T magnetic resonance angiography (MRA) versus digital subtraction angiography (DSA) in the depiction of infrageniculate arteries in patients with symptomatic peripheral arterial disease. PATIENTS AND METHODS:A prospective 1.5 T, 3 T MRA, and DSA co...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000262581.52315.ef
更新日期:2007-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors determine the value of contrast-enhanced, three-dimensional (3D) magnetic resonance angiography (MRA) in the assessment of the renal arteries in comparison with conventional arteriography (CA). METHODS:One hundred three patients (71 m, 32 f) were evaluated with both CA and 3D MRA. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199809000-00021
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the frequency and characteristics of artifacts in segmentation-based attenuation correction maps (μ-maps) of positron emission tomography/magnetic resonance (PET/MR) and their impact on PET interpretation and the standardized uptake value (SUV) quantification in no...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000131
更新日期:2015-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare trabecular bone structure measures obtained in magnetic resonance images of the distal radius and the calcaneus as well as computed tomographic images of the spine versus bone mineral density (BMD) of the spine and the calcaneus in the prediction of osteoporotic spine fracture status...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000129154.50654.4e
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Imaging of the kidney using blood oxygen level dependent MR presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. We sought to define the differences between regions within kidneys and to optimize selection of regions of interest ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c1e8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able to detect alterations in the microvascular perfusion and arterial perfusion reserve in patients suffering from peripheral arterial disease (PAD) in comparison with hea...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182183a77
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To determine whether liver metastases conspicuity is improved at 80 kVp when compared with weighted average (WA) simulated 120 kVp data using dual source dual energy CT. METHODS:A total of 11 patients with 44 hypo-vascular liver metastases underwent contrast enhanced Dual Energy CT (DECT). In all cases the sub...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181dfda78
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To determine whether time-resolved magnetic resonance angiography (TR-MRA) with ultra-low-dose gadolinium chelate (1.5-3.0 mL) can reliably detect or rule out hemodynamically significant disease in the carotid-vertebral artery territory. MATERIALS AND METHODS:Hundred consecutive patients (62 women, 38 men, mea...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31819ca048
更新日期:2009-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the short-term effects of a new nitinol stent on canine arteries. METHODS:Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199905000-00007
更新日期:1999-05-01 00:00:00
abstract::A battery of tests for toxicity assessment of new contrast media is reviewed. Cell toxicity in a protozoan culture (Blepharisma americanum); lethal dose determination in mice; EEG Spectral analysis following cisternography in rabbits; ED50 and LD50 determination by intra- and pericerebral injection in rats; intraciste...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00053
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of x-ray dark-field imaging in projection radiography-based depiction of pneumothoraces in the neonatal murine lung, a potentially life-threatening medical condition that requires a timely and correct diagnosis. MATERIALS AND METHODS:By the use of a ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000285
更新日期:2016-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied the long-term distribution of gadolinium (Gd) in mice and rats after the administration of four commercially available magnetic resonance imaging contrast media. The goals were to determine any possible product dissociation in vivo and to evaluate the effects that product ex...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199506000-00008
更新日期:1995-06-01 00:00:00
abstract::Magnetic resonance spectroscopy (MRS) has been most extensively applied to the study of animal models and not humans. The major reason for this extensive animal research is due to the nature of the early magnetic resonance high-field magnets, which only permitted the study of isolated cells, tissues, or small animals....
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198912000-00004
更新日期:1989-12-01 00:00:00
abstract::The extent to which various concentrations of the paramagnetic metal ions [gadolinium (III), manganese (II), chromium (III), iron (III), nickel (II), copper (II), and cobalt (II)] affect proton magnetic relaxation times of distilled water, 4% human serum albumin (HSA), and dog plasma was studied in vitro. The pH of wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198602000-00009
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVE:To quantify independent pharmacokinetic parameters for differentiation of prostate pathology. MATERIAL AND METHODS:Twenty-seven patients with biopsy-proven prostate cancer (PSA: 1.4-16.1 ng/mL) underwent magnetic resonance imaging with a new dynamic contrast-enhanced, inversion-prepared dual-contrast gradien...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816b2f63
更新日期:2008-07-01 00:00:00
abstract::The contrast sensitivity of the retina is greatest in the center and decreases rapidly toward the periphery. Therefore, the detection of low-contrast lung nodules depends upon the manner in which the image is sampled by retinal receptors as eye fixations jump across the image during scanning. The scanning performance ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198705000-00010
更新日期:1987-05-01 00:00:00