Combined methods for assessment of neurotoxicity: testing of new nonionic radiographic media.

Abstract:

:A battery of tests for toxicity assessment of new contrast media is reviewed. Cell toxicity in a protozoan culture (Blepharisma americanum); lethal dose determination in mice; EEG Spectral analysis following cisternography in rabbits; ED50 and LD50 determination by intra- and pericerebral injection in rats; intracisternal injection in chronically cannulated, nonanesthetized rats; and aversive conditioning by intracisternal injection in rats were found complementary. By these methods, novel nonionic media phenyl-sugar-ether DS-1-132 and DL-2-99 were found comparable to iopamidol, while all three compounds were superior to metrizamide.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Sovak M,Siefert HM,Ranganathan R

doi

10.1097/00004424-198011001-00053

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

S248-53

issue

6 Suppl

eissn

0020-9996

issn

1536-0210

journal_volume

15

pub_type

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