Experimental preparations and models for MRS.

Abstract:

:Magnetic resonance spectroscopy (MRS) has been most extensively applied to the study of animal models and not humans. The major reason for this extensive animal research is due to the nature of the early magnetic resonance high-field magnets, which only permitted the study of isolated cells, tissues, or small animals. However, equally important was the necessity of using animal models in the investigation of both the MRS technique itself and the actual biochemistry and physiology it interrogates. The advantages and disadvantages of various experimental models for magnetic resonance spectroscopy (MRS) research are presented, along with guidelines for choosing an appropriate model for a given experimental requirement.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Balaban RS

doi

10.1097/00004424-198912000-00004

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

948-50

issue

12

eissn

0020-9996

issn

1536-0210

journal_volume

24

pub_type

杂志文章,评审
  • Adenosine-stress dynamic myocardial CT perfusion imaging: initial clinical experience.

    abstract:OBJECTIVE:To evaluate the feasibility of adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual source computed tomography (CT) for the qualitative and quantitative assessment of myocardial blood flow (MBF) compared with stress perfusion and viability magnetic resonance imaging (MRI). ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181dfa2f2

    authors: Bastarrika G,Ramos-Duran L,Rosenblum MA,Kang DK,Rowe GW,Schoepf UJ

    更新日期:2010-06-01 00:00:00

  • Intrapulmonary 3He gas distribution depending on bolus size and temporal bolus placement.

    abstract:OBJECTIVE:Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on insp...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181690111

    authors: Gast KK,Hawig K,Windirsch M,Markstaller K,Schreiber WG,Schmiedeskamp J,Düber C,Kauczor HU,Heussel CP

    更新日期:2008-06-01 00:00:00

  • Assessment of cerebral blood flow in man by video dilution technique: a preliminary report.

    abstract::Video dilution technique (VDT) is currently performed in conjunction with routine cerebral angiography to determine carotid blood flow in humans. Preliminary results indicate that the blood flows (as a percentage of cardial output) of the common, internal, and external carotid arteries are 8.5%, 5.5%, and 3.0%, respec...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198105000-00004

    authors: Lantz BM,Dublin AB,McGahan JP,Link DP

    更新日期:1981-05-01 00:00:00

  • Diatrizoate contrast agents: 2-amino-5-acetamido-, and 3,5-diamino-2,4,6-triiodobenzoates.

    abstract::We have examined the metabolic behavior of several triiodobenzoic acid derivatives because of the observed mutagenicity and cytotoxicity of 3-amino-5-acetamido-2,4,6-triiodobenzoate (I) and 3,5-diamino-2,4,6-triiodobenzoate (II). Measurements were facilitated using iodine-131 (131I)-labeled compounds. Drug retention i...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Weiss R,Hsu B,Wheeler L,Norman A,Riley RF

    更新日期:1981-11-01 00:00:00

  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach: Comparison of 3 Contrast Agents and Recommendation of Feasible Doses.

    abstract:OBJECTIVE:The aims of this study were to compare 3 contrast agents and to define feasible doses for quantitative lung perfusion imaging using the dual-bolus approach in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Ten healthy volunteers (6 males, 4 females; mean age, 23.5 yea...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000224

    authors: Veldhoen S,Oechsner M,Fischer A,Weng AM,Kunz AS,Bley TA,Köstler H,Ritter CO

    更新日期:2016-03-01 00:00:00

  • Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

    abstract:RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200211000-00001

    authors: Schumann PA,Christiansen JP,Quigley RM,McCreery TP,Sweitzer RH,Unger EC,Lindner JR,Matsunaga TO

    更新日期:2002-11-01 00:00:00

  • Detection of emphysema with computed tomography. Correlation with pulmonary function tests and chest radiography.

    abstract::We studied 60 male patients who had concurrent chest films (CXR), computed tomography scans (CT) and pulmonary function tests (PFT) to assess the sensitivity of CT and conventional films in detecting emphysema compared with PFT. We also sought to determine whether emphysema could be diagnosed by CT in patients with no...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198804000-00004

    authors: Sanders C,Nath PH,Bailey WC

    更新日期:1988-04-01 00:00:00

  • A double-blind comparative study of Hexabrix and Renografin-76 in aortography and visceral arteriography.

    abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-198411001-00012

    authors: Barth KH,Mertens MA

    更新日期:1984-11-01 00:00:00

  • Influences on the rate of absorption of the cholecystographic contrast medium iosumetic acid in man.

    abstract::Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197607000-00009

    authors: Speck U,Clauss W,Blumenbach L,Albrecht A

    更新日期:1976-07-01 00:00:00

  • Searching for lung nodules. A comparison of human performance with random and systematic scanning models.

    abstract::The contrast sensitivity of the retina is greatest in the center and decreases rapidly toward the periphery. Therefore, the detection of low-contrast lung nodules depends upon the manner in which the image is sampled by retinal receptors as eye fixations jump across the image during scanning. The scanning performance ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198705000-00010

    authors: Kundel HL,Nodine CF,Thickman D,Toto L

    更新日期:1987-05-01 00:00:00

  • Ultrahigh-field imaging of the biliary tract at 7 T: initial results of gadoxetic acid-enhanced magnetic resonance cholangiography.

    abstract:OBJECTIVES:The objectives of this study were to assess the feasibility of magnetic resonance cholangiography (MRC) using biliary-secreted gadoxetic acid at 7 T and to compare it with T2-weighted (w) MRC at 3 T. MATERIALS AND METHODS:Ten healthy volunteers were examined on a 7-T whole-body magnetic resonance system. T2...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000004

    authors: Fischer A,Kraff O,Orzada S,Nensa F,Schäfer LC,Ladd ME,Umutlu L,Lauenstein TC

    更新日期:2014-05-01 00:00:00

  • Image Quality and Geometric Distortion of Modern Diffusion-Weighted Imaging Sequences in Magnetic Resonance Imaging of the Prostate.

    abstract:PURPOSE:The aim of this study was to compare qualitative and quantitative image quality and geometric distortion of 4 magnetic resonance diffusion-weighted imaging (DWI) sequences of the prostate using comparable imaging parameters and similar acquisition times. METHODS AND MATERIALS:Axial T2-weighted turbo spin echo ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000429

    authors: Stocker D,Manoliu A,Becker AS,Barth BK,Nanz D,Klarhöfer M,Donati OF

    更新日期:2018-04-01 00:00:00

  • Safety and efficacy of dotarem (Gd-DOTA) versus magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system.

    abstract:RATIONALE AND OBJECTIVES:Gd-DTPA is a well-characterized, safe contrast agent frequently used in magnetic resonance imaging (MRI) of the central nervous system. The purpose of this double-blind, comparative MRI study of brain, spine, trunk, and limbs was to evaluate the safety and efficacy of Gd-DOTA versus Gd-DTPA in ...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199502000-00002

    authors: Oudkerk M,Sijens PE,Van Beek EJ,Kuijpers TJ

    更新日期:1995-02-01 00:00:00

  • Ultrasonic detection of osteomyelitis. Pathologic correlation in an animal model.

    abstract::The authors correlated sonographic findings with histologic findings in a rabbit model of osteomyelitis. Staphylococcus aureus osteomyelitis was induced in the femora of 11 New Zealand white rabbits. The opposite leg was used as a control. Sonographic findings showed fluid adjacent to the bone in 11 cases. The fluid w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199202000-00002

    authors: Abiri MM,DeAngelis GA,Kirpekar M,Abou AN,Ablow RC

    更新日期:1992-02-01 00:00:00

  • Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.

    abstract:OBJECTIVE:The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan. MATERIALS AND METHODS:After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000186569.32408.95

    authors: White GW,Gibby WA,Tweedle MF

    更新日期:2006-03-01 00:00:00

  • Radiofrequency balloon angioplasty. Rationale and proof of principle.

    abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00004424-198811000-00002

    authors: Becker GJ,Lee BI,Waller BF,Barry KJ,Kaplan J,Connolly R,Dreesen RG,Nardella P

    更新日期:1988-11-01 00:00:00

  • Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

    abstract::An agent has been identified in lymph from rat kidneys rendered ischemic by partial renal artery occlusion that induces a striking neovascular response in a hamster cheek-pouch assay system. The factor has a high molecular weight, cannot be identified in lymph from normal kidneys, and is associated with a marked incre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198501000-00015

    authors: Hollenberg NK,Paskins-Hurlburt AJ,Abrams HL

    更新日期:1985-01-01 00:00:00

  • Low-dose transaxial tomography. An alternative to computed tomography for the evaluation of anteversion of the femur during childhood.

    abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Kushner DC,Cleveland RH,Ehrlich MG,Zaleske DJ,DeLuca SA,Herman TE,Webster EW

    更新日期:1985-12-01 00:00:00

  • Ioversol clinical safety summary.

    abstract::The authors evaluated double-blind comparative and open-label clinical trials in 1,186 patients who received ioversol to evaluate the safety and efficacy of ioversol, a new nonionic low-osmolality contrast medium, at iodine concentrations of 32%, 24%, and 16%. The results indicate that ioversol was well tolerated in a...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-198906001-00020

    authors: Benamor M,Aten EM,McElvany KD,Lankin DG,James MA,Buy-Gandal T,Harashe LT,Weinandt WJ

    更新日期:1989-06-01 00:00:00

  • Technical feasibility and performance studies of a 0.009-inch nitinol microguidewire for potential neuroendovascular applications.

    abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199704000-00008

    authors: Putman CM,Chaloupka JC,Kailasnath P,Alderman J

    更新日期:1997-04-01 00:00:00

  • Evaluation of gadolinium 2,5-BPA-DO3A, a new macrocyclic hepatobiliary chelate, in normal liver and metastatic disease on high field magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:A new hepatobiliary gadolinium chelate, gadolinium (Gd) 2,5-BPA-DO3A, was compared in two animal species with Gd HP-DO3A (gadoteridol), a clinically approved extracellular contrast agent, and Gd Cy2-DOTA, a second hepatobiliary chelate in preclinical development. The ligand in Gd 2,5-BPA-DO3A i...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199601000-00003

    authors: Runge VM,Wells JW,Williams NM

    更新日期:1996-01-01 00:00:00

  • The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.

    abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198507000-00009

    authors: Dae M,Canhasi B,Botvinick E,Olvera S,Schechtmann N,Engelstad B,Hattner R,Schiller N,O'Connell W,Faulkner D

    更新日期:1985-07-01 00:00:00

  • Magnetic resonance microscopy of the rat carotid artery at 300 megahertz.

    abstract:RATIONALE AND OBJECTIVES:Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this article, the unique adaptations of MRM required in the study of caro...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199409000-00004

    authors: Arnder L,Zhou X,Cofer GP,Hedlund LW,Johnson GA

    更新日期:1994-09-01 00:00:00

  • Applications of voxel shifting in magnetic resonance imaging.

    abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199012000-00006

    authors: Kramer D,Li A,Simovsky I,Hawryszko C,Hale J,Kaufman L

    更新日期:1990-12-01 00:00:00

  • Systolic flow displacement correlates with future ascending aortic growth in patients with bicuspid aortic valves undergoing magnetic resonance surveillance.

    abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000064

    authors: Burris NS,Sigovan M,Knauer HA,Tseng EE,Saloner D,Hope MD

    更新日期:2014-10-01 00:00:00

  • 3.0 Tesla high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) of the pulmonary circulation: initial experience with a 32-channel phased array coil using a high relaxivity contrast agent.

    abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000261937.77365.6a

    authors: Nael K,Fenchel M,Krishnam M,Finn JP,Laub G,Ruehm SG

    更新日期:2007-06-01 00:00:00

  • Contrast media-induced renal tubular vacuolization. A light and electron microscopic study on rat kidneys.

    abstract::The morphologic changes in healthy rat kidneys (n = 102) were studied 2 or 48 hours after intravenous injection of 1 or 3 g iodine (I)/kg of high-osmolality diatrizoate, low-osmolality iopromide and iohexol, or iso-osmolality iotrolan, as well as after 0.2 or 0.6 g/kg of the high-osmolality magnetic resonance contrast...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199110000-00009

    authors: Tervahartiala P,Kivisaari L,Kivisaari R,Virtanen I,Standertskjöld-Nordenstam CG

    更新日期:1991-10-01 00:00:00

  • Influence of clinical history upon detection of nodules and other lesions.

    abstract::The authors reexamined a suspected difference in the effects of clinical information upon detection of nodules vs. more diverse lesions by directly incorporating classification specificity into detection ROC analysis. Categorical prompts, correct for specific abnormalities, led to detection superior to unprompted read...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198801000-00011

    authors: Berbaum KS,Franken EA Jr,Dorfman DD,Barloon TJ

    更新日期:1988-01-01 00:00:00

  • Peripheral magnetic resonance angiography with continuous table movement in combination with high spatial and temporal resolution time-resolved MRA With a total single dose (0.1 mmol/kg) of gadobutrol at 3.0 T.

    abstract:PURPOSE:To prove the concept of peripheral continuous table movement (CTM) MR-angiography (MRA) in combination with high spatial and temporal resolution time-resolved TWIST-MRA in a single MR-examination at 3.0 T with a single dose (0.1 mmol/kg) of gadobutrol in total. MATERIALS AND METHODS:We included 22 consecutive ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181b4c26c

    authors: Voth M,Haneder S,Huck K,Gutfleisch A,Schönberg SO,Michaely HJ

    更新日期:2009-09-01 00:00:00

  • Can Ferumoxytol be Used as a Contrast Agent to Differentiate Between Acute and Chronic Inflammatory Kidney Disease?: Feasibility Study in a Rat Model.

    abstract:OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000209

    authors: Budjan J,Neudecker S,Schock-Kusch D,Kraenzlin B,Schoenberg SO,Michaely HJ,Attenberger UI

    更新日期:2016-02-01 00:00:00