Abstract:
RATIONALE AND OBJECTIVES:Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this article, the unique adaptations of MRM required in the study of carotid artery disease are outlined. The techniques of MRM are integrated into a specific model of carotid artery disease in the rat to allow in vivo studies of vascular wall thickening after removal of the vascular endothelium. METHODS:Imaging was performed at 300 MHz in 250-gm Sprague-Dawley rats using surgically implanted radiofrequency coils to localize the region of interest and to provide an increase in the signal-to-noise ratio over that of volume or surface coils. A three-dimensional Fourier encoding sequence was modified with flow-dephasing gradients to minimize signal and artifacts from moving blood. RESULTS:In vivo images were acquired with spatial resolution of 25 x 25 x 400 microns and signal-to-noise ratio more than sufficient to define the morphology of the vascular wall. Significant changes in the intensity and distribution of signal were visible in the area surrounding the vessel after angioplasty. CONCLUSIONS:Signal-to-noise improvements from surgically implanted coils coupled to a three-dimensional radiofrequency-refocused sequence with flow-dephasing gradients were sufficient to define the wall of the carotid artery. The diffusion-weighted pulse sequence detects signal changes in the area surrounding the vessel after angioplasty. The MRM techniques described and the contrast observed allow us, for the first time to follow in vivo the early stage of developing atherosclerosis in the vessel wall and closely surrounding tissue.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Arnder L,Zhou X,Cofer GP,Hedlund LW,Johnson GAdoi
10.1097/00004424-199409000-00004subject
Has Abstractpub_date
1994-09-01 00:00:00pages
822-6issue
9eissn
0020-9996issn
1536-0210journal_volume
29pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00015
更新日期:1994-03-01 00:00:00
abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198507000-00009
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to test the feasibility of an investigational dual-channel next-generation endorectal coil (NG-ERC) in vivo, to quantitatively assess signal-to-noise ratio (SNR), and to get an impression of image quality compared with the current clinically available single-loop endorectal ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182a56678
更新日期:2014-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The results of an in vitro mixed hemadsorption (MHA) assay predicted the success of in vivo tumor localization using a radioiodinated, monoclonal, IgG1 antibody (A2) with reactivity to the human bladder carcinoma cell line RT4. In vitro, murine monoclonal antibodies A2 and G6, demonstrated reactivity to RT4 with titer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198411000-00011
更新日期:1984-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare electron beam tomography (EBT) with MR imaging (MRI) for detection of restenosis after coronary angioplasty (PTCA). METHODS:One hundred eighteen patients after PTCA were investigated. By EBT, 50 axial images were acquired (3-mm slice thickness, 120-160 mL radiographic contrast agent...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200207000-00005
更新日期:2002-07-01 00:00:00
abstract::Renal arteriography gives a reliable anatomic delineation of the renal vasculature. However, the presence of renal arterial disease does not determine the physiologic significance of the lesion. The intravenous infusion of saralasin, a specific angiotensin II antagonist, has been investigated as a method for identify...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197711000-00006
更新日期:1977-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess quantitative ultra-high b-value (UHB) diffusion magnetic resonance imaging (MRI)-derived parameters in comparison to standard clinical apparent diffusion coefficient (SD-ADC-2b-1000, SD-ADC-2b-1500) for the prediction of clinically significant prostate cancer, defined as G...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000712
更新日期:2021-02-01 00:00:00
abstract::We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the trace...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198309000-00007
更新日期:1983-09-01 00:00:00
abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::Recent publications of the magnetic resonance safety profile of neurostimulators, cardiac pacemakers, and other implanted devices imply that these devices are no longer a contraindication for magnetic resonance imaging. It is very promising that patients who have these implanted devices may in the future no longer be ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000185898.59140.91
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000582
更新日期:2019-10-01 00:00:00
abstract::The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30 and 45 minutes was measured using quantitative computed tomography. Bloo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198411001-00007
更新日期:1984-11-01 00:00:00
abstract::Experimental pulmonary arteritis was produced in rabbits by intravenous injection of alveolar macrophages from donor rabbits. These animals, along with matched controls, were studied with pulmonary angiography to test the hypothesis that angiography could detect the vasculitic process in life. The animals were then sa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198007000-00005
更新日期:1980-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study evaluated the value of dynamically enhanced fast low-angle shot (FLASH) magnetic resonance (MR) imaging in measuring cardiac output with and without dipyridamole pharmacological stress. METHODS:Ten subjects underwent rest and stress MR imaging. Rest images were acquired using electr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199611000-00003
更新日期:1996-11-01 00:00:00
abstract::Perfluoroctylbromide (PFOB), a radiopaque reticuloendothelial system contrast media for computed tomography, has been shown to accumulate in macrophages. In the current study PFOB was tested in rabbits as an abscess imaging agent. Two abscesses were induced in each of 24 rabbits, one in the liver and the other in the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198409000-00017
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000261937.77365.6a
更新日期:2007-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The reflux of ethanol into the peritoneal cavity during percutaneous ethanol injection therapy (PEIT) of liver neoplasms may cause pain and other side effects. This article studies the optimal injection technique to minimize the reflux of ethanol. METHODS:A technique using normal postmortem pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199211000-00008
更新日期:1992-11-01 00:00:00
abstract::Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199006000-00011
更新日期:1990-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000381
更新日期:2017-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199704000-00008
更新日期:1997-04-01 00:00:00
abstract::There are a number of sonographic findings seen in fibroadenoma of the breast. In a retrospective study, we examined the biopsy results of 59 masses given the sonographic diagnosis of fibroadenoma. We also reviewed the sonograms of an additional 26 biopsy-proven fibroadenomas that were not diagnosed as such with ultra...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198601000-00006
更新日期:1986-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors report on the development and preliminary validation of a technique for measuring contrast-to-noise ratio (CNR) at all points along selected vessel segments in the original three-dimensional magnetic resonance angiography (MRA) dataset. METHODS:Contrast-to-noise ratio dependencies ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199311000-00005
更新日期:1993-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate postmortem metabolic and morphologic alterations in the dog brain thalamus and to contribute diagnostic aids in medicolegal science. METHODS:A homogeneous group of 17 dogs was used for in vivo 1H magnetic resonance (MR) spectroscopy and electron microscopic studies, which were p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199505000-00001
更新日期:1995-05-01 00:00:00
abstract::Using cardiac-gated fast acquisition with multiple excitation (FAME), time curves of the cerebral aqueduct signals were derived in 19 healthy volunteers and 14 patients. A mean curve of the normal subjects was determined during systole. A relatively stable point of time was found at 270 msec after the R-wave supposed ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198911000-00004
更新日期:1989-11-01 00:00:00
abstract::Twenty-six patients who had received 43 grafts were studied before and after coronary artery vein bypass surgery. Cine ventriculograms taken in the right anterior oblique projection were analyzed and regional ejection fractions calculated. Single and multiple grafts were considered separately as were thrombosed and pa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197705000-00001
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to validate quantitation of R2* and DeltaR2* measurements obtained with a 3-dimensional (3-D) multiple gradient-recalled echo (mGRE) sequence for evaluating intrarenal oxygenation in humans. MATERIALS AND METHODS:Validation was accomplished (1) by comparing R2* values with pre...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000187166.43871.fb
更新日期:2006-02-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
更新日期:1988-11-01 00:00:00
abstract::A nonionic contrast medium (iohexol) was evaluated for safety and efficacy in pediatric angiocardiography in this study of 15 patients, age 6 to 82 months. Patients carried a preliminary diagnosis of congenital heart disease. Subjects were injected with iohexol, 350 mg iodine/ml of solution with an average volume of 2...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00016
更新日期:1985-05-01 00:00:00