abstract：OBJECTIVES:The aim of this study was to assess quantitative ultra-high b-value (UHB) diffusion magnetic resonance imaging (MRI)-derived parameters in comparison to standard clinical apparent diffusion coefficient (SD-ADC-2b-1000, SD-ADC-2b-1500) for the prediction of clinically significant prostate cancer, defined as G...

journal_title：Investigative radiology

authors： Tavakoli AA,Kuder TA,Tichy D,Radtke JP,Görtz M,Schütz V,Stenzinger A,Hohenfellner M,Schlemmer HP,Bonekamp D

更新日期：2021-02-01 00:00:00

abstract：MATERIALS AND METHODS:Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset frequencies of 600 and 1000 Hz, before and 1 month post-PTRA in 7 RVD pigs. Stenotic kidney MTR was correlated to renal perfusion, renal blood flo...

journal_title：Investigative radiology

authors： Afarideh M,Jiang K,Ferguson CM,Woollard JR,Glockner JF,Lerman LO

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear. OBJECTIVE:We investigated the factors ass...

journal_title：Investigative radiology

authors： Galmiche C,Moal B,Marnat G,Sagnier S,Schweitzer C,Dousset V,Sibon I,Tourdias T

更新日期：2021-01-19 00:00:00

abstract：:Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...

journal_title：Investigative radiology

authors： Damilakis J

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the impact of a novel iterative denoising and image enhancement technique in T1-weighted precontrast and postcontrast volume-interpolated breath-hold examination (VIBE) of the abdomen on image quality, noise levels, and diagnostic confidence without change of acquisit...

journal_title：Investigative radiology

authors： Gassenmaier S,Afat S,Nickel D,Kannengiesser S,Herrmann J,Hoffmann R,Othman AE

更新日期：2020-11-18 00:00:00

abstract：:Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted microbubble (MBThy1) contrast agent that specifically recognizes Thy1 antigen overexpressed in the vasculature of...

journal_title：Investigative radiology

authors： Bam R,Daryaei I,Abou-Elkacem L,Vilches-Moure JG,Meuillet EJ,Lutz A,Marinelli ER,Unger EC,Gambhir SS,Paulmurugan R

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to present a deep learning approach for the automated classification of multiple sclerosis and its mimics and compare model performance with that of 2 expert neuroradiologists. MATERIALS AND METHODS:A total of 268 T2-weighted and T1-weighted brain magnetic resonance imagin scans ...

journal_title：Investigative radiology

authors： Rocca MA,Anzalone N,Storelli L,Del Poggio A,Cacciaguerra L,Manfredi AA,Meani A,Filippi M

更新日期：2020-10-26 00:00:00

abstract：OBJECTIVES:Magnetic resonance imaging guidance has been sporadically reported for renal tumor cryoablation (CA); therefore, clinical experience with this modality is still limited.The aim of this study is to retrospectively analyze our 10-year experience with renal tumor CA performed on a 1.5 T magnetic resonance imagi...

journal_title：Investigative radiology

authors： Cazzato RL,De Marini P,Leonard-Lorant I,Leclerc L,Auloge P,Tricard T,Dalili D,Garnon J,Lang H,Gangi A

更新日期：2020-09-04 00:00:00

abstract：:Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of ap...

journal_title：Investigative radiology

authors： Schöckel L,Jost G,Seidensticker P,Lengsfeld P,Palkowitsch P,Pietsch H

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Over the recent years, there have been increasing concerns that exposure to gadolinium-based contrast agents (GBCAs) may be associated with retention of Gd within the skin, bones, and solid organs in patients with normal renal function, although the clinical implications of this deposition remain to be estab...

journal_title：Investigative radiology

authors： Layne KA,Wood DM,Dixon-Zegeye M,Archer JRH,Raja K,Dargan PI

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to conduct a radiopathologic evaluation of right-angled traction bronchiectasis to differentiate idiopathic pulmonary fibrosis (IPF) without honeycombing from idiopathic nonspecific interstitial pneumonia (NSIP). MATERIALS AND METHODS:The derivation cohort included 78 consecutive p...

journal_title：Investigative radiology

authors： Kim H,Yoon SH,Lee HJ,Song SG,Koh J,Jeon YK,Chae KJ,Jin GY,Jin KN,Lee KY,Goo JM

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:In late December 2019, an outbreak of coronavirus disease (COVID-19) in Wuhan, China was caused by a novel coronavirus, newly named severe acute respiratory syndrome coronavirus 2. We aimed to quantify the severity of COVID-19 infection on high-resolution chest computed tomography (CT) and to determine its r...

journal_title：Investigative radiology

authors： Xiong Y,Sun D,Liu Y,Fan Y,Zhao L,Li X,Zhu W

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...

journal_title：Investigative radiology

authors： Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SR

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...

journal_title：Investigative radiology

authors： Tokuda J,Wang Q,Tuncali K,Seethamraju RT,Tempany CM,Schmidt EJ

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to develop a method to determine hepatic and renal clearance of the 2 diastereoisomers (Gd-A, Gd-B) of Gd-EOB-DTPA separately. MATERIALS AND METHODS:Between July 2017 and February 2018, 41 patients with hepatic disease were prospectively included. For each patient, 1 mL of iopromid...

journal_title：Investigative radiology

authors： Yuan X,Wang S,Shi W,Cai Y,Chen Y,Chen M,Peng Y,Ao G

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

journal_title：Investigative radiology

authors： Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare a compressed-sensing free-breathing VIBE (fbVIBE) with a conventional breath-hold VIBE (bhVIBE) for dynamic contrast-enhanced imaging of the upper abdomen. MATERIALS AND METHODS:In total, 70 datasets (bhVIBE, n = 30; fbVIBE n = 40; hard-gated [hg] reconstruction, n = 30;...

journal_title：Investigative radiology

authors： Hausmann D,Niemann T,Kreul D,Nocito A,Klarhöfer M,Nickel DM,Kiefer B,Attenberger UI,Zöllner FG,Kubik-Huch RA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...

journal_title：Investigative radiology

authors： Kobe A,Puippe G,Klotz E,Alkadhi H,Pfammatter T

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to demonstrate feasibility of measuring extracellular pH in cartilage and meniscus using acidoCEST technique with a 3-dimensional ultrashort echo time readout (acidoCEST-UTE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Magnetization transfer ratio asymmetry, radiofrequ...

journal_title：Investigative radiology

authors： Ma YJ,High RA,Tang Q,Wan L,Jerban S,Du J,Chang EY

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...

journal_title：Investigative radiology

authors： Szomolanyi P,Rohrer M,Frenzel T,Noebauer-Huhmann IM,Jost G,Endrikat J,Trattnig S,Pietsch H

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers. MATERIALS AND METHODS:One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectivel...

journal_title：Investigative radiology

authors： Panda A,OʼConnor G,Lo WC,Jiang Y,Margevicius S,Schluchter M,Ponsky LE,Gulani V

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to assess the discriminative performance of quantitative multiparametric magnetic resonance imaging (mpMRI) between prostate cancer and noncancer tissues and between tumor grade groups (GGs) in a multicenter, single-vendor study, and to investigate to what extent site-specific dif...

journal_title：Investigative radiology

authors： Maas MC,Litjens GJS,Wright AJ,Attenberger UI,Haider MA,Helbich TH,Kiefer B,Macura KJ,Margolis DJA,Padhani AR,Selnæs KM,Villeirs GM,Fütterer JJ,Scheenen TWJ

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...

journal_title：Investigative radiology

authors： Kromrey ML,Friedrich N,Hoffmann RT,Bülow R,Völzke H,Weiss FU,Lerch MM,Motosugi U,Kühn JP

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the impact on metal artifacts and dose efficiency of using a tin filter in combination with high-energy threshold (TH) images of a photon-counting detector (PCD) computed tomography (CT) system. MATERIALS AND METHODS:A 3D-printed spine with pedicle screws was scanned...

journal_title：Investigative radiology

authors： Zhou W,Bartlett DJ,Diehn FE,Glazebrook KN,Kotsenas AL,Carter RE,Fletcher JG,McCollough CH,Leng S

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess and compare the overall performance, reliability, variability, as well as the accuracy of diffusion tensor imaging (DTI) and fiber tracking metrics, for the muscles of the calf at 3 T and 7 T. MATERIALS AND METHODS:Ten volunteers (5 males; mean age, 29.1 ± 4.7 years), with...

journal_title：Investigative radiology

authors： Giraudo C,Motyka S,Weber M,Feiweier T,Trattnig S,Bogner W

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results...

journal_title：Investigative radiology

authors： Perkuhn M,Stavrinou P,Thiele F,Shakirin G,Mohan M,Garmpis D,Kabbasch C,Borggrefe J

更新日期：2018-11-01 00:00:00

abstract：:The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...

journal_title：Investigative radiology

authors： Runge VM

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the feasibility of a prototype volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (VIBECS) for rapid multiphase arterial magnetic resonance imaging (MRI) at different temporal resolution during free-breathing in comparison with a convention...

journal_title：Investigative radiology

authors： Weiss J,Notohamiprodjo M,Taron J,Martirosian P,Nickel D,Bamberg F,Nikolaou K,Othman AE

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS:A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline...

journal_title：Investigative radiology

authors： Große Hokamp N,Salem J,Hesse A,Holz JA,Ritter M,Heidenreich A,Maintz D,Haneder S

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tom...

journal_title：Investigative radiology

authors： Frellesen C,Azadegan M,Martin SS,Otani K,DʼAngelo T,Booz C,Eichler K,Panahi B,Kaup M,Bauer RW,Vogl TJ,Wichmann JL

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to analyze the effect of dual-energy computed tomography (DECT) scanners and fluid characteristics on iodine quantification and to calculate the measurement variability range induced by those variables. METHODS:We performed an experimental phantom study with 4 mediastinal iodine ...

journal_title：Investigative radiology

authors： Kim H,Goo JM,Kang CK,Chae KJ,Park CM

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare qualitative and quantitative image quality and geometric distortion of 4 magnetic resonance diffusion-weighted imaging (DWI) sequences of the prostate using comparable imaging parameters and similar acquisition times. METHODS AND MATERIALS:Axial T2-weighted turbo spin echo ...

journal_title：Investigative radiology

authors： Stocker D,Manoliu A,Becker AS,Barth BK,Nanz D,Klarhöfer M,Donati OF

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear...

journal_title：Investigative radiology

authors： Ryu YJ,Choi YH,Cheon JE,Lee WJ,Park S,Park JE,Kim WS,Kim IO

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...

journal_title：Investigative radiology

authors： Quattrocchi CC,Errante Y,Mallio CA,Marinelli L,LoVullo G,Giannotti G,Della Sala SW,van der Molen AJ,Beomonte Zobel B

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS:In this institutional r...

journal_title：Investigative radiology

authors： Symons R,Reich DS,Bagheri M,Cork TE,Krauss B,Ulzheimer S,Kappler S,Bluemke DA,Pourmorteza A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate a prototype dual-energy computed tomography calcium subtraction algorithm and its impact on luminal visualization in patients with heavily calcified coronary arteries. MATERIALS AND METHODS:Twenty-nine patients (62% male; mean age, 64 ± 7 years) who had undergone dual-e...

journal_title：Investigative radiology

authors： De Santis D,Jin KN,Schoepf UJ,Grant KL,De Cecco CN,Nance JW Jr,Vogl TJ,Laghi A,Albrecht MH

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...

journal_title：Investigative radiology

authors： Freedman JN,Collins DJ,Bainbridge H,Rank CM,Nill S,Kachelrieß M,Oelfke U,Leach MO,Wetscherek A

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical i...

journal_title：Investigative radiology

authors： Kneepkens E,Heijman E,Keupp J,Weiss S,Nicolay K,Grüll H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-t...

journal_title：Investigative radiology

authors： Tsuboyama T,Jost G,Pietsch H,Tomiyama N

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:BR55, a vascular endothelial growth factor receptor 2 (VEGFR2)-specific ultrasound molecular contrast agent (MCA), has shown promising results in multiple preclinical models regarding cancer imaging. In this first-in-human, phase 0, exploratory study, we investigated the feasibility and safety of the MCA for ...

journal_title：Investigative radiology

authors： Smeenge M,Tranquart F,Mannaerts CK,de Reijke TM,van de Vijver MJ,Laguna MP,Pochon S,de la Rosette JJMCH,Wijkstra H

更新日期：2017-07-01 00:00:00