Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

abstract：:Methods are presented for the quantification of spatial resolution in x-ray computed tomographic (CT) images. Model-dependent methods are derived and compared with model independent methods for computation of the Modulation Transfer Function (MTF). These techniques are applied to phantom images of point, line, edge, a...

journal_title：Investigative radiology

authors： Assimakopoulos PA,Boyd DP,Jaschke W,Lipton MJ

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine to what degree current compressed sensing methods are capable of accelerating clinical magnetic resonance neuroimaging sequences. METHODS:Two 2-dimensional clinical sequences were chosen for this study because of their long scan times. A pilot study was used to establish ...

journal_title：Investigative radiology

authors： Sharma SD,Fong CL,Tzung BS,Law M,Nayak KS

更新日期：2013-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:A new hepatobiliary gadolinium chelate, gadolinium (Gd) 2,5-BPA-DO3A, was compared in two animal species with Gd HP-DO3A (gadoteridol), a clinically approved extracellular contrast agent, and Gd Cy2-DOTA, a second hepatobiliary chelate in preclinical development. The ligand in Gd 2,5-BPA-DO3A i...

journal_title：Investigative radiology

authors： Runge VM,Wells JW,Williams NM

更新日期：1996-01-01 00:00:00

abstract：:Compounds containing mobile protons can act as contrast agents by increasing the value of the term (1/12 - 1/11). The efficiency of this method is markedly pH- and field-dependent. There are many such compounds allowing a choice to be made based on the characteristics of the tissue or organ, magnetic field strength, a...

journal_title：Investigative radiology

authors： Aime S,Nano R,Grandi M

更新日期：1988-09-01 00:00:00

abstract：:In this article, we propose a semiautomatic method for time-continuous contour detection in all phases of the cardiac cycle in magnetic resonance sequences. The method is based on multidimensional dynamic programming. After shape parameterization, cost hypercubes are filled with image-feature derived cost function val...

journal_title：Investigative radiology

authors： Uzümcü M,van der Geest RJ,Swingen C,Reiber JH,Lelieveldt BP

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...

journal_title：Investigative radiology

authors： Freedman JN,Collins DJ,Bainbridge H,Rank CM,Nill S,Kachelrieß M,Oelfke U,Leach MO,Wetscherek A

更新日期：2017-10-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...

journal_title：Investigative radiology

authors： Kennedy AS,Archambeau JO,Archambeau MH,Holshouser B,Thompson J,Moyers M,Hinshaw D Jr,Slater JM

更新日期：1995-04-01 00:00:00

abstract：:The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...

journal_title：Investigative radiology

authors： Hayes R,Mahon T,Masterson J,Owens A

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...

journal_title：Investigative radiology

authors： Budjan J,Neudecker S,Schock-Kusch D,Kraenzlin B,Schoenberg SO,Michaely HJ,Attenberger UI

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...

journal_title：Investigative radiology

authors： Kromrey ML,Friedrich N,Hoffmann RT,Bülow R,Völzke H,Weiss FU,Lerch MM,Motosugi U,Kühn JP

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:BR55, a vascular endothelial growth factor receptor 2 (VEGFR2)-specific ultrasound molecular contrast agent (MCA), has shown promising results in multiple preclinical models regarding cancer imaging. In this first-in-human, phase 0, exploratory study, we investigated the feasibility and safety of the MCA for ...

journal_title：Investigative radiology

authors： Smeenge M,Tranquart F,Mannaerts CK,de Reijke TM,van de Vijver MJ,Laguna MP,Pochon S,de la Rosette JJMCH,Wijkstra H

更新日期：2017-07-01 00:00:00

abstract：:The extent to which various concentrations of the paramagnetic metal ions [gadolinium (III), manganese (II), chromium (III), iron (III), nickel (II), copper (II), and cobalt (II)] affect proton magnetic relaxation times of distilled water, 4% human serum albumin (HSA), and dog plasma was studied in vitro. The pH of wa...

journal_title：Investigative radiology

authors： Barnhart JL,Berk RN

更新日期：1986-02-01 00:00:00

abstract：:Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...

journal_title：Investigative radiology

authors： Damilakis J

更新日期：2021-01-01 00:00:00

abstract：:The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...

journal_title：Investigative radiology

authors： Barth KH,Lutz RJ,Kremers PW,Miller DL

更新日期：1988-07-01 00:00:00

abstract：:The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...

journal_title：Investigative radiology

authors： Kundel HL,Revesz G,Toto L

更新日期：1979-01-01 00:00:00

abstract：:The biliary and urinary excretion of sodium tyropanoate (Bilopaque) and sodium ipodate (Oragrafin) were studied in unanesthetized bile-fistula dogs using stepwise, increasing, intravenous infusions of the contrast materials. A constant intravenous infusion of sodium taurocholate was administered at the rate of either ...

journal_title：Investigative radiology

authors： Berk RN,Loeb PM,Cobo-Frenkel A,Barnhart JL

更新日期：1977-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Ureteric jet index (UJI), a newly developed technique derived from color Doppler ultrasonography, may hold promise in evaluating renal function because of its ability to evaluate individual renal function and the use of nonionizing radiation. To assess the usefulness of UJI, the authors in this...

journal_title：Investigative radiology

authors： Chiu NT,Wu CC,Yao WJ,Tu DG,Lee BF,Tong YC,Pan CC

更新日期：1999-08-01 00:00:00

abstract：:The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...

journal_title：Investigative radiology

authors： Kuribayashi S,Garnic JD,Abrams HL

更新日期：1982-11-01 00:00:00

abstract：PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...

journal_title：Investigative radiology

authors： Bachmann R,Nassenstein I,Kooijman H,Dittrich R,Kugel H,Niederstadt T,Kuhlenbäumer G,Ringelstein EB,Krämer S,Heindel W

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare qualitative and quantitative image quality and geometric distortion of 4 magnetic resonance diffusion-weighted imaging (DWI) sequences of the prostate using comparable imaging parameters and similar acquisition times. METHODS AND MATERIALS:Axial T2-weighted turbo spin echo ...

journal_title：Investigative radiology

authors： Stocker D,Manoliu A,Becker AS,Barth BK,Nanz D,Klarhöfer M,Donati OF

更新日期：2018-04-01 00:00:00

abstract：UNLABELLED:Szapiro D, Ghaye B, Willems V, et al. Evaluation of CT time-density curves of lower-limb veins. Invest Radiol 2001;36:164-169. RATIONALE AND OBJECTIVES:To evaluate time-density curves of the lower-limb veins for optimization of CT venography. METHODS:Fifty patients referred for chest CT were randomized int...

journal_title：Investigative radiology

authors： Szapiro D,Ghaye B,Willems V,Zhang L,Albert A,Dondelinger RF

更新日期：2001-03-01 00:00:00

abstract：:Pyrroxamide [N-(1-hydroxymethyl-2,3-dihydroxypropyl)-2,2,5,5-tetramethyl pyrrolidine-1-oxyl-3-carboxyamide] is a newly tested nonionic monomeric nitroxyl compound with demonstrated effectiveness for MRI contrast enhancement at doses as low as 10(-3) M. Pyrroxamide and its hydroxylamine metabolic derivative were tested...

journal_title：Investigative radiology

authors： Gordon DG,Brasch RC,Ogan MD,Deen D

更新日期：1988-08-01 00:00:00

abstract：:The effects of an intravenously administered nitroxyl spin label (PCA) on the magnetic resonance imaging (MRI) appearance and relaxation times of acute canine myocardial infarctions were studied. Twenty-four hours after ligation of the left anterior descending coronary artery (LAD), animals were either sacrificed imme...

journal_title：Investigative radiology

authors： McNamara MT,Wesbey GE,Brasch RC,Sievers R,Lipton MJ,Higgins CB

更新日期：1985-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size mi...

journal_title：Investigative radiology

authors： Aref M,Brechbiel M,Wiener EC

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the feasibility of a prototype volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (VIBECS) for rapid multiphase arterial magnetic resonance imaging (MRI) at different temporal resolution during free-breathing in comparison with a convention...

journal_title：Investigative radiology

authors： Weiss J,Notohamiprodjo M,Taron J,Martirosian P,Nickel D,Bamberg F,Nikolaou K,Othman AE

更新日期：2018-10-01 00:00:00

abstract：:Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted microbubble (MBThy1) contrast agent that specifically recognizes Thy1 antigen overexpressed in the vasculature of...

journal_title：Investigative radiology

authors： Bam R,Daryaei I,Abou-Elkacem L,Vilches-Moure JG,Meuillet EJ,Lutz A,Marinelli ER,Unger EC,Gambhir SS,Paulmurugan R

更新日期：2020-11-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To investigate image mottle in conventional CT images of the abdomen as a function of radiographic technique factors and patient size. METHODS:Water-filled phantoms simulating the abdomens of adult (32 cm in diameter) and pediatric (16 cm in diameter) patients were used to investigate image mo...

journal_title：Investigative radiology

authors： Ende JF,Huda W,Ros PR,Litwiller AL

更新日期：1999-04-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The influence of lipiodol injection on hepatic morphology and function was investigated in 119 rabbits with hepatic VX2 tumors. METHODS:The rabbits were divided into the following three groups, according to the materials injected via the proper hepatic artery: group 1 received doxorubicin (Adr...

journal_title：Investigative radiology

authors： Akashi Y,Koreeda C,Mizuno T,Inoue K,Kawa SK,Tanaka Y

更新日期：1993-02-01 00:00:00

abstract：:We measured the amounts of three types of radiographic contrast media (RCM) that could be entrapped in liposomes prepared by the dehydration-rehydration vesicle (DRV) technique. To make DRVs, one initially makes water-containing, small unilamellar vesicles, adds contrast media and lyophilizes the mixture. Upon rehydra...

journal_title：Investigative radiology

authors： Seltzer SE,Gregoriadis G,Dick R

更新日期：1988-02-01 00:00:00

abstract：:An allergic, immunologic mechanism for certain adverse reactions to radiocontrast agents has been postulated on the basis of clinical and theoretical considerations. One obstacle to the acceptance of this allergic theory has been the inability to demonstrate significant antibodies with specificity for these agents. In...

journal_title：Investigative radiology

authors： Brasch RC,Caldwell JL

更新日期：1976-09-01 00:00:00