Abstract:
OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic resonance imaging of the pancreas, and organ fat content was quantified by using confounder corrected PDFF. Exocrine pancreatic function was categorized by fecal elastase levels using defined cutoffs: greater than 200 μg/g normal function (n = 1319) and 200 μg/g or less impaired function (n = 139). Statistical analysis to correlate pancreatic fat content with fecal elastase included linear regression, and analyses were adjusted for known confounders for pancreatic steatosis, such as age, sex, and body mass index. RESULTS:Overall mean (±standard deviation) of pancreatic fat content was 7.50% ± 3.78%. Pancreatic fat content was significantly higher in subjects with impaired pancreatic exocrine function (9.36% ± 4.95%) compared with subjects with normal function (7.30% ± 3.59%; P < 0.01). Linear regression analyses showed an inverse correlation between pancreatic fat and fecal elastase levels over the whole study population (beta, -7.19 [standard error, 1.39]; P < 0.01) as well as in the subgroup of subjects with normal function (-4.26 [1.32]; P < 0.01). Among subjects with impaired pancreatic exocrine function, a trend toward an inverse relation was detected (-1.28 [0.84]; P < 0.13). CONCLUSIONS:An inverse correlation between PDFF of the pancreas and fecal elastase suggests an association between pancreatic steatosis and impaired pancreatic exocrine function.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Kromrey ML,Friedrich N,Hoffmann RT,Bülow R,Völzke H,Weiss FU,Lerch MM,Motosugi U,Kühn JPdoi
10.1097/RLI.0000000000000554subject
Has Abstractpub_date
2019-07-01 00:00:00pages
403-408issue
7eissn
0020-9996issn
1536-0210journal_volume
54pub_type
杂志文章abstract:RATIONAL AND OBJECTIVES:Magnetic resonance (MR) scan technique and lesion detectability were evaluated using a newly developed spinal abscess model in the New Zealand White rabbit. METHODS:To create the lesion, an epidural needle was inserted under fluoroscopic guidance in the lumbar region and advanced to penetrate t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199804000-00008
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abstract:RATIONALE AND OBJECTIVES:Gray scale and power Doppler sonography are commonly used to evaluate cervical lymph nodes. This study was undertaken to identify which of the features used in ultrasound of cervical lymph nodes is readily applicable in routine clinical practice. METHODS:Two hundred and eight-six patients diag...
journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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