Abstract:
OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the detection of PDAC. MATERIALS AND METHODS:From March 2017 through May 2019, a total of 54 study participants with healthy pancreas (n = 33, CTR) or PDAC (n = 21) were prospectively enrolled. Repeatability of THE was tested in a CTR subgroup (n = 5) undergoing repeat measurement on 4 different days. Interobserver variability was analyzed in 10 healthy volunteers. Age-matched and sex-matched subgroups of CTR (n = 13) and PDAC (n = 13) were compared. In participants with histopathologically proven PDAC, measurements were performed separately in tumorous (PDAC-T) and nontumorous pancreatic tissue (PDAC-NT). Diagnostic performance of pancreatic THE was assessed by receiver operating characteristic curve analysis. RESULTS:Time-harmonic elastography was highly repeatable (intraclass correlation coefficient, 0.99), and interobserver agreement was excellent (intraclass correlation coefficient, 0.97). Shear wave speed (SWS) of PDAC-T (mean [95% confidence interval] in meters per second, 1.88 ± 0.07 [1.84-1.92]) was higher than SWS of CTR (1.63 ± 0.04 [1.60-1.66], P < 0.001) and PDAC-NT (1.59 ± 0.03 [1.57-1.61], P < 0.001). The exploratory diagnostic performance of THE in separating PDAC-T was excellent (area under the receiver operating characteristic curve, 1.0). Tumorous pancreatic ductal adenocarcinoma was distinguished from CTR and PDAC-NT with cutoff values of 1.73 m/s and 1.70 m/s, respectively. CONCLUSIONS:Pancreatic ultrasound THE has high repeatability and provides excellent imaging contrast based on SWS, allowing detection of PDAC without overlap to nontumorous pancreatic tissue.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SRdoi
10.1097/RLI.0000000000000638subject
Has Abstractpub_date
2020-05-01 00:00:00pages
270-276issue
5eissn
0020-9996issn
1536-0210journal_volume
55pub_type
杂志文章abstract::The rate at which isotopes descend from the cisterna magna to the lumbar subarachnoid space is highly variable. In monkeys, with and without previous lumbar puncture, transit time was measured. In animals with a previous lumbar puncture, transit times were 10 to 120 minutes; in monkeys without a previous lumbar punctu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198805000-00005
更新日期:1988-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Because of the complex relationships between the dynamic three-dimensional cardiac surface shape and its projected image, errors arise with the use of two-dimensional silhouettes to measure displacements of the heart. The character and frequency of such errors are examined. METHODS:A high-prec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00004
更新日期:1994-03-01 00:00:00
abstract::Flow measurements can be made with computed tomography (CT) scanners using iodinated, nonionic contrast media as a first-pass indicator. Ultrafast CT (UFCT) is an ideal machine to make these measurements because of its short scan time (50 mseconds) and interscan delay (< or = 0.6 seconds). Additionally, UFCT can acqui...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199212002-00004
更新日期:1992-12-01 00:00:00
abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...
journal_title:Investigative radiology
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doi:10.1097/00004424-199012000-00006
更新日期:1990-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS:In 10 experiments with mongrel dogs, the contrast agents were alternately injected ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199212000-00011
更新日期:1992-12-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0000000000000111
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199001000-00014
更新日期:1990-01-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816b2f63
更新日期:2008-07-01 00:00:00
abstract::The use of microbubble contrast agents for general tissue delineation and perfusion enjoys steady interest in ultrasound imaging. Microbubbles as contrast materials require a small dosage and show excellent detection sensitivity. Targeting ligands on the surface of microbubbles permit the selective accumulation of the...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS:Twenty patients with no cardiac ab...
journal_title:Investigative radiology
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更新日期:2009-04-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000248893.01067.e5
更新日期:2007-01-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198403000-00007
更新日期:1984-03-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3180cc2041
更新日期:2007-11-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e3181b4c26c
更新日期:2009-09-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-197807000-00005
更新日期:1978-07-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197701000-00017
更新日期:1977-01-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199106000-00004
更新日期:1991-06-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0000000000000712
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e3181bfe2d2
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journal_title:Investigative radiology
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更新日期:2001-04-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-198003000-00004
更新日期:1980-03-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-199701000-00011
更新日期:1997-01-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-198908000-00007
更新日期:1989-08-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
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journal_title:Investigative radiology
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更新日期:2018-04-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-199612000-00007
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journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00