Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.

abstract：:Lymphangiograms of canine cardiac and pulmonary efferent mediastinal lymphatics were made by cannulation and injection of Ethiodol. Injections were made singly and serially. The mediastinal lymphatics and lymph nodes, which constitute the pathways of drainage of the heart and lungs, were delineated from the point of c...

journal_title：Investigative radiology

authors： Leeds SE,Uhley HN,Meister RB

更新日期：1979-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Magnetic resonance imaging (MRI) techniques seem to be very promising for 3D dosimetry studies, but long imaging acquisition time limits their use. A new fast T1 mapping protocol, easy to implement on a conventional MR imager, has been used to determine dose distributions on Fricke gels. METHO...

journal_title：Investigative radiology

authors： Calmet C,Vincensini D,Bonnet J,Bertino C,Catala A,Martinez M,Joffre F

更新日期：1999-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The effect of varying exposure parameters on the detectability of a fracture with digital and conventional radiography were examined. METHODS:A macerated fractured skull was imaged by film-screen radiography (FSR) and digital storage phosphor radiography (DR) with various exposure values. Five...

journal_title：Investigative radiology

authors： Langen HJ,Klein HM,Wein B,Schiwy-Bochat KH,Stargardt A,Günther RW

更新日期：1993-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Ureteric jet index (UJI), a newly developed technique derived from color Doppler ultrasonography, may hold promise in evaluating renal function because of its ability to evaluate individual renal function and the use of nonionizing radiation. To assess the usefulness of UJI, the authors in this...

journal_title：Investigative radiology

authors： Chiu NT,Wu CC,Yao WJ,Tu DG,Lee BF,Tong YC,Pan CC

更新日期：1999-08-01 00:00:00

abstract：:A prospective, randomized study of the potential protective effects of corticosteroids administered as pretreatment against contrast material (CM) reactions is reported. Patients (n = 6,763) from multiple institutions received either a single dose of steroids (32 mg of oral methylprednisolone, approximately 2 hours be...

journal_title：Investigative radiology

authors： Lasser EC,Berry CC,Talner LB,Santini LC,Lang EK,Gerber FH,Stolberg HO

更新日期：1988-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors detect activation in the auditory cortex during cochlear electrical stimulation in deaf patients using functional magnetic resonance (MR) imaging. METHODS:Stimulating electrode was inserted gently under local anesthesia close to the round window membrane of the cochlea in seven coc...

journal_title：Investigative radiology

authors： Berthezène Y,Truy E,Morgon A,Giard MH,Hermier M,Franconi JM,Froment JC

更新日期：1997-05-01 00:00:00

abstract：:Fractures modeled in the dried skull indicate that the initial plane of computed tomography (CT) section contributes to the accuracy of three-dimensional (3D) images generated from two-dimensional (2D) CT data. The authors retrospectively analyzed seven clinical cases of tripod zygomatic fractures that were imaged wit...

journal_title：Investigative radiology

authors： Levy RA,Kellman RM,Rosenbaum AE

更新日期：1991-05-01 00:00:00

abstract：:Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...

journal_title：Investigative radiology

authors： Clark RL,Friedman M,Kwock L,Zaremba J

更新日期：1983-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The clinically most widely used devices (Porstmann-plug, Rashkind-umbrella, Botallooccluder) have inherent specific limitations (eg, transarterial approach, residual shunts, limited retrieval). The authors assess practicability, efficacy, and tissue reaction of the new retrievable transvenous p...

journal_title：Investigative radiology

authors： Grabitz RG,Schräder R,Sigler M,Seghaye MC,Dzionsko C,Handt S,Schneidt B,Von Bernuth G

更新日期：1997-09-01 00:00:00

abstract：:Methods are presented for the quantification of spatial resolution in x-ray computed tomographic (CT) images. Model-dependent methods are derived and compared with model independent methods for computation of the Modulation Transfer Function (MTF). These techniques are applied to phantom images of point, line, edge, a...

journal_title：Investigative radiology

authors： Assimakopoulos PA,Boyd DP,Jaschke W,Lipton MJ

更新日期：1986-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...

journal_title：Investigative radiology

authors： Putman CM,Chaloupka JC,Kailasnath P,Alderman J

更新日期：1997-04-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors studied premenopausal, perimenopausal, and postmenopausal women to determine if ultrasound bone velocity (UBV) on proximal phalanges of women reflect bone changes related to gonadal status and age. METHODS:A total of 166 healthy women-64 postmenopausal women (mean age 58.7 +/- 9.4 ...

journal_title：Investigative radiology

authors： Aguado F,Revilla M,Hernández ER,Villa LF,Rico H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:Contrast-enhanced ultrasound imaging is increasingly being used in the clinic for assessment of tissue vascularity. The purpose of our study was to evaluate the effect of different contrast administration parameters on the in vivo ultrasound imaging signal in tumor-bearing mice using a maximum intensity pers...

journal_title：Investigative radiology

authors： Pysz MA,Foygel K,Panje CM,Needles A,Tian L,Willmann JK

更新日期：2011-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To evaluate the effect of the transverse ligament on translation of the menisci. METHODS:Six cadaveric knees were examined by MR imaging inside a positioning device before and after transecting the transverse ligament. The knees were examined at various positions: extension, 30 degrees of flex...

journal_title：Investigative radiology

authors： Muhle C,Thompson WO,Sciulli R,Pedowitz R,Ahn JM,Yeh L,Clopton P,Haghighi P,Trudell DJ,Resnick D

更新日期：1999-09-01 00:00:00

abstract：:The authors compared the renal toxicity of the low osmolality radiocontrast agents, iohexol and ioxaglate, and the ionic agent, iothalamate, at equivalent iodine dose, using experimental models in vitro and in vivo. In isolated perfused rat kidneys, all agents induced comparable biphasic hemodynamic changes, associate...

journal_title：Investigative radiology

authors： Brezis M,Greenfeld Z,Herman M,Meyer JJ,Heyman SN,Rosen S

更新日期：1991-04-01 00:00:00

abstract：:Observation of the relaxivity of MRI contrast media over a wide range of magnetic fields is not only necessary for predicting their efficiency at any field but also compulsory for understanding and improving their mechanisms of action. The best experimental approach to this problem is the field cycling method, which a...

journal_title：Investigative radiology

authors： Muller RN,Vander Elst L,Rinck PA,Vallet P,Maton F,Fischer H,Roch A,Van Haverbeke Y

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVES:The purposes of this study were to evaluate the reference range of quantitative computed tomography (QCT) measures of lung attenuation and airway parameter measurements in healthy nonsmoking adults and to identify sources of variation in those measures and possible means to adjust for them. MATERIALS AND ME...

journal_title：Investigative radiology

authors： Zach JA,Newell JD Jr,Schroeder J,Murphy JR,Curran-Everett D,Hoffman EA,Westgate PM,Han MK,Silverman EK,Crapo JD,Lynch DA,COPDGene Investigators.

更新日期：2012-10-01 00:00:00

abstract：:Analysis of 46 sacroiliac joints removed in toto at random during routine autopsies was undertaken to define the pathologic and radiographic alterations of this joint in middle-aged and elderly patients. Each joint was sectioned, photographed and radiographed and large microscopic slides were prepared. Sacroiliac oste...

journal_title：Investigative radiology

authors： Resnick D,Niwayama G,Goergen TG

更新日期：1975-11-01 00:00:00

abstract：:Frequency spectral analysis of cardiac wall motion as calculated from the recorded video kymogram are demonstrated. Characteristic harmonics following the fundamental frequency of the cardiac rate have been demonstrated to have an alternating sequential energy distribution as measured from the free margin of the left ...

journal_title：Investigative radiology

authors： Silverman NR,Rosen L,Helland DR

更新日期：1975-03-01 00:00:00

abstract：:In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with dia...

journal_title：Investigative radiology

authors： Kim SH,Lee HK,Han MC

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to assess the feasibility of magnetic resonance cholangiography (MRC) using biliary-secreted gadoxetic acid at 7 T and to compare it with T2-weighted (w) MRC at 3 T. MATERIALS AND METHODS:Ten healthy volunteers were examined on a 7-T whole-body magnetic resonance system. T2...

journal_title：Investigative radiology

authors： Fischer A,Kraff O,Orzada S,Nensa F,Schäfer LC,Ladd ME,Umutlu L,Lauenstein TC

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to achieve initial experience with non-contrast-enhanced (ne) magnetic resonance angiography (MRA) of the lower leg arteries in patients with peripheral arterial occlusive disease (PAOD) at 7 T. MATERIALS AND METHODS:Seven patients with PAOD were examined on a 7-T whole-body magnet...

journal_title：Investigative radiology

authors： Fischer A,Maderwald S,Johst S,Orzada S,Ladd ME,Umutlu L,Lauenstein TC,Kniemeyer HW,Nassenstein K

更新日期：2014-05-01 00:00:00

abstract：:Thirty patients [four normals, eight with mild and 18 with severe coronary artery disease (CAD)] were studied to evaluate left ventricular function type and post coronary angiography. The end diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF) and the regional contractility fractions (RCF) of eig...

journal_title：Investigative radiology

authors： Sos TA,Baltaxe HA

更新日期：1976-03-01 00:00:00

abstract：:The potential risk of a radiologic procedure often is compared with the potential benefit of the procedure. While risk vs. benefit analysis has been useful as a step toward increased communication and understanding among radiologists, referring physicians, and the general public, it has the disadvantage that risk and ...

journal_title：Investigative radiology

authors： Ritenour ER,Hendee WR

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of saline chase injected at 2 different rates on computed tomography (CT) angiography. MATERIALS AND METHODS:This study was approved by our institutional animal study committee. Three injection protocols were used; contrast injection (24 mL, 0.8 mL/s) without saline chase (protocol ...

journal_title：Investigative radiology

authors： Lee CH,Goo JM,Bae KT,Lee HJ,Kim KG,Chun EJ,Park CM,Im JG

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:The aim of the present study was to evaluate the potential of high-resolution MRI at 2 Tesla (T) for direct noninvasive imaging of the aortic wall in a mouse model of atherosclerosis. MATERIAL AND METHODS:A specific mouse antenna was developed and sequence parameters were adjusted. T(1)- and T2-weighted i...

journal_title：Investigative radiology

authors： Chaabane L,Soulas EC,Contard F,Salah A,Guerrier D,Briguet A,Douek P

更新日期：2003-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors studied the long-term distribution of gadolinium (Gd) in mice and rats after the administration of four commercially available magnetic resonance imaging contrast media. The goals were to determine any possible product dissociation in vivo and to evaluate the effects that product ex...

journal_title：Investigative radiology

authors： Tweedle MF,Wedeking P,Kumar K

更新日期：1995-06-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions. MATERIALS AND METHODS:A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar s...

journal_title：Investigative radiology

authors： Puttagunta NR,Gibby WA,Puttagunta VL

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVES:We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial in...

journal_title：Investigative radiology

authors： Srichai MB,Lim RP,Lath N,Babb J,Axel L,Kim D

更新日期：2013-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To evaluate the use of a new thrombus-specific ultrasound contrast agent, MRX-408, in the ultrasonic detection of thrombus in arteriovenous (AV) fistulae. METHODS:Six purpose-bred mongrels with two AV fistulae each were imaged with gray-scale ultrasound 7 weeks after graft implantation before ...

journal_title：Investigative radiology

authors： Unger E,Metzger P 3rd,Krupinski E,Baker M,Hulett R,Gabaeff D,Mills J,Ihnat D,McCreery T

更新日期：2000-01-01 00:00:00