Abstract:
RATIONALE AND OBJECTIVES:To evaluate the use of a new thrombus-specific ultrasound contrast agent, MRX-408, in the ultrasonic detection of thrombus in arteriovenous (AV) fistulae. METHODS:Six purpose-bred mongrels with two AV fistulae each were imaged with gray-scale ultrasound 7 weeks after graft implantation before and after the intravenous bolus injection of MRX-408 (a GPIIb receptor-targeted ultrasound contrast agent). Pre- and postcontrast videotaped segments were randomized and reviewed by four radiologists blinded to the presence of thrombus in the grafts. RESULTS:After the use of MRX-408, there was improved visualization of thrombus within the grafts (P < 0.0001). This was due to the enhancement of the thrombus (P < 0.0001). The improved visualization and contrast enhancement were more marked in the grafts that contained thrombus nonhyperechoic to surrounding soft tissues. CONCLUSIONS:MRX-408 demonstrated better visualization of thrombus within AV fistulae. This was shown in both patent and occluded grafts. These results are encouraging and suggest that this contrast agent merits further development.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Unger E,Metzger P 3rd,Krupinski E,Baker M,Hulett R,Gabaeff D,Mills J,Ihnat D,McCreery Tdoi
10.1097/00004424-200001000-00010keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
86-9issue
1eissn
0020-9996issn
1536-0210journal_volume
35pub_type
杂志文章abstract::Percutaneous injection of absolute ethanol into adenocarcinomas implanted in the hind leg of rats was evaluated as a potential cancer treatment. Intramuscular alcohol injections up to 10 mL/kg produced a local dose-dependent coagulation necrosis followed by granulation tissue formation and subsequent fibrosis but no a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198706000-00005
更新日期:1987-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::Skeletal abnormalities have been reported on numerous occasions in patients who have received high doses of vitamin A and its derivatives. Recently, a new derivative, isotretinoin (Accutane, Hoffman-LaRoche, Inc.), has become available for the treatment of cystic acne. Ninety-six patients treated for a minimum of four...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198601000-00007
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to conduct a radiopathologic evaluation of right-angled traction bronchiectasis to differentiate idiopathic pulmonary fibrosis (IPF) without honeycombing from idiopathic nonspecific interstitial pneumonia (NSIP). MATERIALS AND METHODS:The derivation cohort included 78 consecutive p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000651
更新日期:2020-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors assessed whether a non-sleep-deprived, second-year diagnostic radiology resident assigned to an after-hours "night stalker" emergency radiology (ER) rotation in an urban university hospital has a measurable impact on the number and clinical significance of "missed" radiologic findin...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199301000-00032
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVES:To determine the impact of slice thickness on semiautomatic lymph node analysis. MATERIALS AND METHODS:Thoracic multislice computed tomography (MSCT) of 46 patients with NSCLC were reconstructed at 1.0-, 3.0-, and 5.0-mm slice thickness. Two radiologists independently determined long and short axis diameter...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181c443e1
更新日期:2010-02-01 00:00:00
abstract::The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000507
更新日期:2018-10-01 00:00:00
abstract::An allergic, immunologic mechanism for certain adverse reactions to radiocontrast agents has been postulated on the basis of clinical and theoretical considerations. One obstacle to the acceptance of this allergic theory has been the inability to demonstrate significant antibodies with specificity for these agents. In...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197609000-00002
更新日期:1976-09-01 00:00:00
abstract::Receiver operating characteristic (ROC) analysis has been used in a broad variety of medical imaging studies during the past 15 years, and its advantages over more traditional measures of diagnostic performance are now clearly established. But despite the essential simplicity of the approach, workers in the field ofte...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198903000-00012
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000209
更新日期:2016-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study evaluated the value of dynamically enhanced fast low-angle shot (FLASH) magnetic resonance (MR) imaging in measuring cardiac output with and without dipyridamole pharmacological stress. METHODS:Ten subjects underwent rest and stress MR imaging. Rest images were acquired using electr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199611000-00003
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000218
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. MATERIAL AND METHODS:After induction of hepatic ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318155aa2e
更新日期:2008-02-01 00:00:00
abstract::We developed a new, cineangiographic method to accurately measure the dynamic changes in the internal diameter of human arteries in vivo. Cine films were digitized at a spatial resolution of 4 microns/pixel, using a line image sensor. The vessel edges, with a Gaussian fit to a unilateral profile curve of the vessel, w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198909000-00005
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the image quality and diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) at 3.0 T compared with that at 1.5 T used for patients. MATERIALS AND METHODS:This study was approved by our institutional review board, and informed consent was obtained from all patien...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c0ae
更新日期:2009-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To characterize the long-term effects of therapeutic doses of ionizing radiation on the uptake and distribution of percutaneously delivered particulate contrast media in normal lymph nodes. METHODS:Two milliliters of an iodinated nanoparticle suspension (76 mg I/mL) was injected subcutaneously...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200003000-00007
更新日期:2000-03-01 00:00:00
abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198201000-00004
更新日期:1982-01-01 00:00:00
abstract::Biplane angiocardiography has emerged as a standard method for calculating left ventricular volume measurements. Validation of such measurements has separately been made for several projections of silicone casts of the left ventricle. This study was undertaken to establish and compare the regression lines for left ven...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011000-00002
更新日期:1980-11-01 00:00:00
abstract::This article reviews the computer system hardware and software, applications programs, and computer network services that are available on microcomputers for use by the radiologist. The American College of Radiology Institute computer network is described, which is specifically designed to help the practicing radiolog...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198602000-00015
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000618
更新日期:2020-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the influence of injection rates and volumes on the arrival time of contrast material (CM) in the common carotid artery, the jugular vein and the resulting arterial-venous transit time. Additionally the relationship between injection parameters and the extent of a CM plateau was evalu...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.rli.0000105040.40925.c8
更新日期:2004-02-01 00:00:00
abstract::The sonographic appearance of kidneys in patients presenting with acute renal failure due to hemolytic-uremic syndrome (HUS) was evaluated and compared with that in an age-matched control series. In nine patients with HUS, the renal cortex was typically hyperechogenic and the renal pyramids appeared sonolucent. The re...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198607000-00006
更新日期:1986-07-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of ex vivo ablation implementing a cryo-based internally cooled bipolar radiofrequency (RF) applicator and to determine the influence of power and gas pressure on the size and shape of the resulting ablation zones. MATERIALS AND METHODS:Two hundred twenty-five ablations were perform...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b66d11
更新日期:2009-12-01 00:00:00
abstract::The effect of three iodinated contrast media (CM) on human plasma butyrylcholinesterase (BuChE) activity was studied during the intravenous pyelography (i.v.P). BuChE is an enzyme that participates in the metabolism of acetylcholine and hydrolyzes food esters and drugs such as nondepolarizing muscle relaxants and loca...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199805000-00008
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate a high spatial resolution 3-dimensional (3D) contrast-enhanced magnetic resonance (CE-MR) venography protocol for evaluation of intracranial venous system using highly accelerated parallel imaging at 3.0 T. MATERIALS AND METHODS:Ten patients (4 male, 6 female; age,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/01.rli.0000236992.21065.04
更新日期:2006-10-01 00:00:00
abstract::Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000727
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To prove the concept of peripheral continuous table movement (CTM) MR-angiography (MRA) in combination with high spatial and temporal resolution time-resolved TWIST-MRA in a single MR-examination at 3.0 T with a single dose (0.1 mmol/kg) of gadobutrol in total. MATERIALS AND METHODS:We included 22 consecutive ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c26c
更新日期:2009-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Measurements of segmental contraction of the left ventricle by standard magnetic resonance imaging (MRI) and two-dimensional echocardiography involve the comparison of diastolic and systolic time frames acquired from the same imaging plane in space. As the cone-shaped left ventricle shortens al...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199209000-00004
更新日期:1992-09-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
更新日期:1988-11-01 00:00:00
abstract::Thirty patients [four normals, eight with mild and 18 with severe coronary artery disease (CAD)] were studied to evaluate left ventricular function type and post coronary angiography. The end diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF) and the regional contractility fractions (RCF) of eig...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197603000-00009
更新日期:1976-03-01 00:00:00