Experimental nephrotoxicity of the radiocontrast agents iohexol, ioxaglate, and iothalamate. An in vitro and in vivo study.

Abstract:

:The authors compared the renal toxicity of the low osmolality radiocontrast agents, iohexol and ioxaglate, and the ionic agent, iothalamate, at equivalent iodine dose, using experimental models in vitro and in vivo. In isolated perfused rat kidneys, all agents induced comparable biphasic hemodynamic changes, associated with similar declines in glomerular filtration rate (GFR) and tubular necrosis. In two different in vivo models (using multiple insults combined with the administration of radiocontrast), iothalamate appeared to induce more severe morphologic injury. Despite similar nephrotoxic potential in vitro, the newer radiocontrast agents, iohexol and ioxaglate, cause in vivo less renal injury than iothalamate in the experimental models.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Brezis M,Greenfeld Z,Herman M,Meyer JJ,Heyman SN,Rosen S

doi

10.1097/00004424-199104000-00008

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

325-31

issue

4

eissn

0020-9996

issn

1536-0210

journal_volume

26

pub_type

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