Toward clinical X-ray phase-contrast CT: demonstration of enhanced soft-tissue contrast in human specimen.

abstract：OBJECTIVE:The purpose of this study was to assess the diagnostic value and safety of the contrast agent gadoterate meglumine (Gd-DOTA, DOTAREM, Guerbet, Roissy CdG Cedex, France) in the setting of a postmarketing surveillance study. MATERIALS AND METHODS:Between January 2004 and October 2005, radiologists in 61 radiol...

journal_title：Investigative radiology

authors： Herborn CU,Honold E,Wolf M,Kemper J,Kinner S,Adam G,Barkhausen J

更新日期：2007-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:As part of a general examination of the effect of blood flow patterns on the growth and risk of rupture of abdominal aortic aneurysms, the authors investigated the flow through an experimental model of a fusiform aneurysm. MATERIALS AND METHODS:Aneurysms were simulated in polyvinyl chloride tu...

journal_title：Investigative radiology

authors： Schrader T,Peattie RA,Bluth EI,Comstock CE

更新日期：1992-07-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...

journal_title：Investigative radiology

authors： Schumann PA,Christiansen JP,Quigley RM,McCreery TP,Sweitzer RH,Unger EC,Lindner JR,Matsunaga TO

更新日期：2002-11-01 00:00:00

abstract：:The results of an in vitro mixed hemadsorption (MHA) assay predicted the success of in vivo tumor localization using a radioiodinated, monoclonal, IgG1 antibody (A2) with reactivity to the human bladder carcinoma cell line RT4. In vitro, murine monoclonal antibodies A2 and G6, demonstrated reactivity to RT4 with titer...

journal_title：Investigative radiology

authors： Gross MD,Skinner RW,Grossman HB

更新日期：1984-11-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To demonstrate the usefulness of a model of the parenchymous vascularization to evaluate texture analysis methods. METHODS:Slices with thickness varying from 1 to 4 mm were reformatted from a 3D vascular model corresponding to either normal tissue perfusion or local hypervascularization. Param...

journal_title：Investigative radiology

authors： Rolland Y,Bézy-Wendling J,Duvauferrier R,Coatrieux JL

更新日期：1999-03-01 00:00:00

abstract：:Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...

journal_title：Investigative radiology

authors： Kim SH,Park JH,Kim YI,Kim CW,Han MC

更新日期：1990-06-01 00:00:00

abstract：:Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...

journal_title：Investigative radiology

authors： Kushner DC,Cleveland RH,Ehrlich MG,Zaleske DJ,DeLuca SA,Herman TE,Webster EW

更新日期：1985-12-01 00:00:00

abstract：:In this article, we propose a semiautomatic method for time-continuous contour detection in all phases of the cardiac cycle in magnetic resonance sequences. The method is based on multidimensional dynamic programming. After shape parameterization, cost hypercubes are filled with image-feature derived cost function val...

journal_title：Investigative radiology

authors： Uzümcü M,van der Geest RJ,Swingen C,Reiber JH,Lelieveldt BP

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of a dual magnetic resonance-near infrared fluorescence optical imaging agent, poly(l-glutamic acid)-DTPA-Gd-NIR813, for both preoperative and intraoperative visualization and characterization of sentinel lymph nodes (SLN) in mice. MATERIALS AND METHODS:Poly(L-glutamic acid) was...

journal_title：Investigative radiology

authors： Melancon MP,Wang Y,Wen X,Bankson JA,Stephens LC,Jasser S,Gelovani JG,Myers JN,Li C

更新日期：2007-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:A new hepatobiliary gadolinium chelate, gadolinium (Gd) 2,5-BPA-DO3A, was compared in two animal species with Gd HP-DO3A (gadoteridol), a clinically approved extracellular contrast agent, and Gd Cy2-DOTA, a second hepatobiliary chelate in preclinical development. The ligand in Gd 2,5-BPA-DO3A i...

journal_title：Investigative radiology

authors： Runge VM,Wells JW,Williams NM

更新日期：1996-01-01 00:00:00

abstract：:In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with dia...

journal_title：Investigative radiology

authors： Kim SH,Lee HK,Han MC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To develop a new animal model for the evaluation of the renal tolerance of contrast agent and its application to diatrizoate and iotrolan injections in comparison to saline and mannitol solution. MATERIALS AND METHODS:The nephrotoxic potential of intravenously injected contrast agents in Beagl...

journal_title：Investigative radiology

authors： Krause W,Gilles T

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-...

journal_title：Investigative radiology

authors： Radbruch A,Weberling LD,Kieslich PJ,Hepp J,Kickingereder P,Wick W,Schlemmer HP,Bendszus M

更新日期：2015-12-01 00:00:00

abstract：:Flow measurements can be made with computed tomography (CT) scanners using iodinated, nonionic contrast media as a first-pass indicator. Ultrafast CT (UFCT) is an ideal machine to make these measurements because of its short scan time (50 mseconds) and interscan delay (< or = 0.6 seconds). Additionally, UFCT can acqui...

journal_title：Investigative radiology

authors： Gould RG

更新日期：1992-12-01 00:00:00

abstract：:Chest radiographs are commonly obtained to assess children for bronchiolitis, both to corroborate the diagnosis and to exclude other diagnostic possibilities. Their utility in this setting has not previously been examined. Using a blinded, randomized study design, we examined the interobserver and intraobserver variat...

journal_title：Investigative radiology

authors： Coblentz CL,Babcook CJ,Alton D,Riley BJ,Norman G

更新日期：1991-02-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The clinically most widely used devices (Porstmann-plug, Rashkind-umbrella, Botallooccluder) have inherent specific limitations (eg, transarterial approach, residual shunts, limited retrieval). The authors assess practicability, efficacy, and tissue reaction of the new retrievable transvenous p...

journal_title：Investigative radiology

authors： Grabitz RG,Schräder R,Sigler M,Seghaye MC,Dzionsko C,Handt S,Schneidt B,Von Bernuth G

更新日期：1997-09-01 00:00:00

abstract：:Observer performance in radiologic interpretation has traditionally been based upon Receiver Operating Characteristic (ROC) analysis. A statistical method that evaluates the reproducibility or consistency of radiologic interpretation is presented. Since this method is not based upon pathologic verification, it cannot ...

journal_title：Investigative radiology

authors： Herman S,DeBoer G,Rideout DF,Majesky IF

更新日期：1984-11-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size mi...

journal_title：Investigative radiology

authors： Aref M,Brechbiel M,Wiener EC

更新日期：2002-04-01 00:00:00

abstract：:Gadolinium was attached to antibodies and tested in vitro and in vivo for its effect on proton relaxation enhancement. Using the cyclic anhydride method, diethylenetriaminepentaacetic acid (DTPA) was attached to albumin, IgG and anti-CEA monoclonal antibody. Gadolinium (Gd) was then chelated to the protein complexes f...

journal_title：Investigative radiology

authors： Unger EC,Totty WG,Neufeld DM,Otsuka FL,Murphy WA,Welch MS,Connett JM,Philpott GW

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to achieve initial experience with non-contrast-enhanced (ne) magnetic resonance angiography (MRA) of the lower leg arteries in patients with peripheral arterial occlusive disease (PAOD) at 7 T. MATERIALS AND METHODS:Seven patients with PAOD were examined on a 7-T whole-body magnet...

journal_title：Investigative radiology

authors： Fischer A,Maderwald S,Johst S,Orzada S,Ladd ME,Umutlu L,Lauenstein TC,Kniemeyer HW,Nassenstein K

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of intravoxel incoherent motion and diffusion-weighted imaging for predicting the histologic grade of pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:Forty patients with surgically diagnosed PNETs who underwent preoperative magnetic resonance im...

journal_title：Investigative radiology

authors： Hwang EJ,Lee JM,Yoon JH,Kim JH,Han JK,Choi BI,Lee KB,Jang JY,Kim SW,Nickel MD,Kiefer B

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], image quality, diagnostic confidence) from a standard brain magnetic resonance imaging examination encompassing common neurological disorders such as demyelinating dis...

journal_title：Investigative radiology

authors： Springer E,Dymerska B,Cardoso PL,Robinson SD,Weisstanner C,Wiest R,Schmitt B,Trattnig S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able to detect alterations in the microvascular perfusion and arterial perfusion reserve in patients suffering from peripheral arterial disease (PAD) in comparison with hea...

journal_title：Investigative radiology

authors： Amarteifio E,Weber MA,Wormsbecher S,Demirel S,Krakowski-Roosen H,Jöres A,Braun S,Delorme S,Böckler D,Kauczor HU,Krix M

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...

journal_title：Investigative radiology

authors： Quattrocchi CC,Errante Y,Mallio CA,Marinelli L,LoVullo G,Giannotti G,Della Sala SW,van der Molen AJ,Beomonte Zobel B

更新日期：2018-04-01 00:00:00

abstract：:Diagnostic radiology is expanding, playing an increasingly central role in patient care, which heightens the importance of radiology teaching in undergraduate medical education. This study examined the impact of increased structure and systematic evaluation on student performance in a radiology elective. The evaluatio...

journal_title：Investigative radiology

authors： Blane CE,Calhoun JG,Maxim BR,Martel W,Davis WK

更新日期：1985-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tom...

journal_title：Investigative radiology

authors： Frellesen C,Azadegan M,Martin SS,Otani K,DʼAngelo T,Booz C,Eichler K,Panahi B,Kaup M,Bauer RW,Vogl TJ,Wichmann JL

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on insp...

journal_title：Investigative radiology

authors： Gast KK,Hawig K,Windirsch M,Markstaller K,Schreiber WG,Schmiedeskamp J,Düber C,Kauczor HU,Heussel CP

更新日期：2008-06-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The aim of the study was to examine the effects of azelastine on proliferation, clonogenic activity, cell-cycle, and migration of human aortic smooth-muscle cells (haSMCs) in vitro. METHODS:HaSMCs were treated for 4 days with azelastine (1 micromol/L, 25 micromol/L, 50 micromol/L). Half of the...

journal_title：Investigative radiology

authors： Schöber W,Wiskirchen J,Kehlbach R,Gebert R,Rodegerdts E,Betsch A,Johst U,Feuls R,Claussen CD,Duda SD

更新日期：2002-05-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To compare the diagnostic efficacy of a standard dose of MRI contrast agent in the evaluation of primary brain tumors and metastases using a high-field 3 tesla MR unit versus a 1.5 tesla MR unit. METHODS:Sixteen patients with brain tumors were examined at both field strengths using identical a...

journal_title：Investigative radiology

authors： Nöbauer-Huhmann IM,Ba-Ssalamah A,Mlynarik V,Barth M,Schöggl A,Heimberger K,Matula C,Fog A,Kaider A,Trattnig S

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:To prospectively evaluate accuracy of biliary anatomy depiction and quality of biliary tract visualization of magnetic resonance cholangiography (MRC) at 3.0 T in living potential liver donors (LPLDs). MATERIALS AND METHODS:Our institutional review board approved this study and did not require patient's inf...

journal_title：Investigative radiology

authors： Kim SY,Byun JH,Hong HS,Choi EK,Lee SS,Park SH,Lee MG

更新日期：2008-08-01 00:00:00