Abstract:
RATIONALE AND OBJECTIVES:The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions. MATERIALS AND METHODS:A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar solution of zinc (Zn) citrate in 1:1 volume ratio at pH 7.4 in a transmetallation assay. In a ligand competition reaction, a DTPA or EDTA solution was mixed with an equimolar solution of Gd-DTPA-BIGA, Gd-DTPA-BMA, or Gd-HP-DO3A. The progress of the reactions was followed with high-performance liquid chromatography (HPLC) using fluorescence detection. RESULTS:In the transmetallation study with Zn citrate, the order of kinetic stability is Gd-HP-DO3A > Gd-DTPA > Gd-DTPA-BIGA > Gd-DTPA-BMA. The order of stability in the ligand competition reaction is Gd-HP-DO3A > Gd-DTPA-BIGA > Gd-DTPA-BMA. CONCLUSIONS:Transmetallation kinetics shows major differences among currently used MR imaging contrast media. Equilibrium thermodynamic constants and selectivity constants calculated therefrom do not explain the relative kinetic stability and metal selectivity of MR contrast media in the presence of competing metal ions and ligands.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Puttagunta NR,Gibby WA,Puttagunta VLdoi
10.1097/00004424-199610000-00003subject
Has Abstractpub_date
1996-10-01 00:00:00pages
619-24issue
10eissn
0020-9996issn
1536-0210journal_volume
31pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000030
更新日期:2014-06-01 00:00:00
abstract::Attenuation correction (AC) is an essential step in the positron emission tomography (PET) data reconstruction process to provide accurate and quantitative PET images. The introduction of PET/magnetic resonance (MR) hybrid systems has raised new challenges but also possibilities regarding PET AC. While in PET/computed...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000289
更新日期:2016-10-01 00:00:00
abstract::A double-blind randomized study of ten patients compared Hexabrix 32% to Renografin-60 in TMJ arthrography. Equivalent volumes of contrast material were injected under fluoroscopic observation, with film quality and patient subjective response graded independently by three radiologists. In immediate arthrogram quality...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00032
更新日期:1984-11-01 00:00:00
abstract::The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000507
更新日期:2018-10-01 00:00:00
abstract::Due to the small size of the bronchial arteries, the bronchial circulation is difficult to study and remains poorly understood. We have utilized single photon emission computed tomography (SPECT) as a noninvasive means of studying the bronchial circulation. Imaging studies were performed in sheep before and after the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199001000-00014
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate if a quantitative evaluation of a magnetic resonance (MR) perfusion examination of the myocardium can achieve a comparable diagnostic accuracy as a semiquantitative evaluation. METHODS:A total of 31 patients with suspected coronary artery disease underwent MR imaging an...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31824f54cb
更新日期:2012-06-01 00:00:00
abstract::Thoracic metastases from squamous carcinoma and adenocarcinoma of the cervix were studied by reviewing 245 consecutive cases to describe comparative incidence, natural history, and radiographic patterns. The incidence of chest metastases was higher for adenocarcinoma (20%) than for squamous carcinoma (4%). Few patient...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198003000-00004
更新日期:1980-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate image mottle in conventional CT images of the abdomen as a function of radiographic technique factors and patient size. METHODS:Water-filled phantoms simulating the abdomens of adult (32 cm in diameter) and pediatric (16 cm in diameter) patients were used to investigate image mo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199904000-00005
更新日期:1999-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The reflux of ethanol into the peritoneal cavity during percutaneous ethanol injection therapy (PEIT) of liver neoplasms may cause pain and other side effects. This article studies the optimal injection technique to minimize the reflux of ethanol. METHODS:A technique using normal postmortem pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199211000-00008
更新日期:1992-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Time-of-flight magnetic resonance angiography (TOF/MRA) is increasingly used to assess the nature and severity of stenotic blood vessels. Flow artifacts associated with high flows and/or narrow constrictions may confuse the interpretation of these studies. Accurate TOF/MRA evaluations demand an...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199307000-00011
更新日期:1993-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of the study was to determine optimal thresholds for semiquantitative perfusion parameters and to evaluate the influence of different segmentation models in detecting malperfused regions. MATERIAL AND METHODS:In 6 healthy subjects and 13 patients with coronary artery disease, contrast-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000133816.83192.38
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES AND RATIONALE:Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199306000-00011
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of a dual magnetic resonance-near infrared fluorescence optical imaging agent, poly(l-glutamic acid)-DTPA-Gd-NIR813, for both preoperative and intraoperative visualization and characterization of sentinel lymph nodes (SLN) in mice. MATERIALS AND METHODS:Poly(L-glutamic acid) was...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31804f5a79
更新日期:2007-08-01 00:00:00
abstract::Iohexol and meglumine-sodium diatrizoate were injected intravenously into 18 pigs as either a 99:1 or 1:99 mixture. Blood samples were taken for 30 minutes and the concentration of each of the two contrast media was measured by means of a double labeling technique with 125I and 131I. Relative concentrations of iohexol...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198511000-00016
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVES:Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000392
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:The authors assessed the relative efficacy of conventional and digital storage-phosphor radiographs for the detection of skull fractures. METHODS:Fifty conventional film-screen radiographs (FSR) and 50 digital storage-phosphor radiographs (DR) with 66 fractures were compared. Five radiologists evaluated ima...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199308000-00005
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:There is little published information regarding the efficacy of paclitaxel-coated balloon catheters except for the iopromide-containing formulation, and less is known about the kind of toxicity at overdose. The aim of our study was to assess 2 different paclitaxel matrix formulations on angioplasty balloon ca...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31820577df
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the image quality and diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) at 3.0 T compared with that at 1.5 T used for patients. MATERIALS AND METHODS:This study was approved by our institutional review board, and informed consent was obtained from all patien...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c0ae
更新日期:2009-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:It is widely believed that down-sizing catheters, and possibly needles, will decrease damage to the entry vessel in the performance of angiography. The purposes of this in vitro experiment are to determine if smaller needles produce less arterial wall damage than larger needles and to assess th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00001
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to achieve initial experience with non-contrast-enhanced (ne) magnetic resonance angiography (MRA) of the lower leg arteries in patients with peripheral arterial occlusive disease (PAOD) at 7 T. MATERIALS AND METHODS:Seven patients with PAOD were examined on a 7-T whole-body magnet...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000044
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Interstitial laser photocoagulation (ILP) causes localized tissue necrosis. This study was performed to determine 1) whether the changes seen on computed tomography (CT) correspond to the necrosis pathologically, and 2) which CT technique best shows the necrosis. METHODS:Eighteen Wistar rats h...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199312000-00014
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the potential of iterative metal artifact reduction (IMAR) for the improvement of computed tomography (CT)-based position emission tomography (PET) attenuation correction in the vicinity of metal implants and compare it with dual-energy-based metal artifact reduction stra...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000306
更新日期:2017-01-01 00:00:00
abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-197811000-00008
更新日期:1978-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the potential of magnetic resonance imaging (MRI) for evaluating the evolution of tumor necrosis, the authors evaluated 28 VX2 carcinomas inoculated in the thigh muscles of rabbits. METHODS:MRI of VX2 carcinomas at 2.0 T was done with spin-echo technique 1 week (14 tumors) and 3 week...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199301000-00010
更新日期:1993-01-01 00:00:00
abstract::Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197607000-00009
更新日期:1976-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare qualitative and quantitative image quality and geometric distortion of 4 magnetic resonance diffusion-weighted imaging (DWI) sequences of the prostate using comparable imaging parameters and similar acquisition times. METHODS AND MATERIALS:Axial T2-weighted turbo spin echo ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000429
更新日期:2018-04-01 00:00:00
abstract::The ideal contrast agent in patients suspected of having gastrointestinal perforation is an iso-osmolar, or nearly iso-osmolar substance, that causes no peritoneal reaction. Iopamidol is a nonionic water-soluble contrast medium that may be considered in such situations. Intraperitoneal injections of ionic and nonionic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199002000-00008
更新日期:1990-02-01 00:00:00
abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00004
更新日期:1979-01-01 00:00:00
abstract::The effect of intravenous urography (IVU) on the excretion rate and precipitation of Tamm-Horsfall glycoprotein (THG) has been evaluated in 19 patients. Urine samples were collected immediately before the administration of contrast medium (U1) and then during the period of the excretion urogram (U2). The urinary THG: ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198501000-00014
更新日期:1985-01-01 00:00:00