Iopamidol as a gastrointestinal contrast agent. Lack of peritoneal reactivity.

Abstract:

:The ideal contrast agent in patients suspected of having gastrointestinal perforation is an iso-osmolar, or nearly iso-osmolar substance, that causes no peritoneal reaction. Iopamidol is a nonionic water-soluble contrast medium that may be considered in such situations. Intraperitoneal injections of ionic and nonionic contrast agents were compared in rats to study potentially harmful peritoneal inflammation. Only intraperitoneal barium injection produced any significant tissue reaction, such as adhesions and ascites. There was no difference between iopamidol and the other water-soluble contrast agents. Iopamidol may satisfy the need for nonreactive and nearly iso-osmolar contrast agents for evaluating patients with possible bowel perforation. However, the high cost of this agent may make its clinical application impractical.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Ferrante SL,Schreiman JS,Rouse JW,Rysavy JA,Cheng SC,Frick MP

doi

10.1097/00004424-199002000-00008

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

141-5

issue

2

eissn

0020-9996

issn

1536-0210

journal_volume

25

pub_type

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