Abstract:
OBJECTIVES:In late December 2019, an outbreak of coronavirus disease (COVID-19) in Wuhan, China was caused by a novel coronavirus, newly named severe acute respiratory syndrome coronavirus 2. We aimed to quantify the severity of COVID-19 infection on high-resolution chest computed tomography (CT) and to determine its relationship with clinical parameters. MATERIALS AND METHODS:From January 11, 2020, to February 5, 2020, the clinical, laboratory, and high-resolution CT features of 42 patients (26-75 years, 25 males) with COVID-19 were analyzed. The initial and follow-up CT, obtained a mean of 4.5 days and 11.6 days from the illness onset were retrospectively assessed for the severity and progression of pneumonia. Correlations among clinical parameters, initial CT features, and progression of opacifications were evaluated with Spearman correlation and linear regression analysis. RESULTS:Thirty-five patients (83%) exhibited a progressive process according to CT features during the early stage from onset. Follow-up CT findings showed progressive opacifications, consolidation, interstitial thickening, fibrous strips, and air bronchograms, compared with initial CT (all P < 0.05). Before regular treatments, there was a moderate correlation between the days from onset and sum score of opacifications (R = 0.68, P < 0.01). The C-reactive protein, erythrocyte sedimentation rate, and lactate dehydrogenase showed significantly positive correlation with the severity of pneumonia assessed on initial CT (Rrange, 0.36-0.75; P < 0.05). The highest temperature and the severity of opacifications assessed on initial CT were significantly related to the progression of opacifications on follow-up CT (P = 0.001-0.04). CONCLUSIONS:Patients with the COVID-19 infection usually presented with typical ground glass opacities and other CT features, which showed significant correlations with some clinical and laboratory measurements. Follow-up CT images often demonstrated progressions during the early stage from illness onset.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Xiong Y,Sun D,Liu Y,Fan Y,Zhao L,Li X,Zhu Wdoi
10.1097/RLI.0000000000000674subject
Has Abstractpub_date
2020-06-01 00:00:00pages
332-339issue
6eissn
0020-9996issn
1536-0210journal_volume
55pub_type
杂志文章abstract:OBJECTIVE:To evaluate the feasibility of adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual source computed tomography (CT) for the qualitative and quantitative assessment of myocardial blood flow (MBF) compared with stress perfusion and viability magnetic resonance imaging (MRI). ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181dfa2f2
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journal_title:Investigative radiology
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00032
更新日期:1984-11-01 00:00:00
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journal_title:Investigative radiology
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doi:
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199605000-00010
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journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e318210ecf5
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journal_title:Investigative radiology
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000446
更新日期:2018-06-01 00:00:00
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0000000000000044
更新日期:2014-05-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-197705000-00009
更新日期:1977-05-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198503000-00016
更新日期:1985-03-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-199802000-00002
更新日期:1998-02-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199902000-00003
更新日期:1999-02-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-198401000-00007
更新日期:1984-01-01 00:00:00
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journal_title:Investigative radiology
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doi:
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doi:10.1097/00004424-199312000-00014
更新日期:1993-12-01 00:00:00
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doi:10.1097/00004424-197801000-00014
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doi:10.1097/00004424-198903000-00012
更新日期:1989-03-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.RLI.0000077124.24140.bd
更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00004424-199508000-00001
更新日期:1995-08-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00006
更新日期:1988-09-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000381
更新日期:2017-10-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000251577.68223.84
更新日期:2007-02-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199507000-00004
更新日期:1995-07-01 00:00:00