T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.


OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten patients with primary non-small cell lung cancer were scanned at 1.5 T axially with a volumetric T2-weighted turbo spin echo sequence gated to exhalation and a volumetric T1-weighted stack-of-stars spoiled gradient echo sequence with golden angle spacing acquired in free breathing. From the latter, 20 respiratory phases were reconstructed using the recently developed 4D joint MoCo-HDTV algorithm based on the self-gating signal obtained from the k-space center. Motion vector fields describing the respiratory cycle were obtained by deformable image registration between the respiratory phases and projected onto the T2-weighted image volume. The resulting 4D-T2w volumes were verified against the 4D-T1w volumes: an edge-detection method was used to measure the diaphragm positions; the locations of anatomical landmarks delineated by a radiation oncologist were compared and normalized mutual information was calculated to evaluate volumetric image similarity. RESULTS:High-resolution 4D-T2w MRI was obtained. Respiratory motion was preserved on calculated 4D-T2w MRI, with median diaphragm positions being consistent with less than 6.6 mm (2 voxels) for all patients and less than 3.3 mm (1 voxel) for 9 of 10 patients. Geometrical positions were coherent between 4D-T1w and 4D-T2w MRI as Euclidean distances between all corresponding anatomical landmarks agreed to within 7.6 mm (Euclidean distance of 2 voxels) and were below 3.8 mm (Euclidean distance of 1 voxel) for 355 of 470 pairs of anatomical landmarks. Volumetric image similarity was commensurate between 4D-T1w and 4D-T2w MRI, as mean percentage differences in normalized mutual information (calculated over all respiratory phases and patients), between corresponding respiratory phases of 4D-T1w and 4D-T2w MRI and the tie-phase of 4D-T1w and 3-dimensional T2w MRI, were consistent to 0.41% ± 0.37%. Four-dimensional T2w MRI displayed tumor extent, structure, and position more clearly than corresponding 4D-T1w MRI, especially when mobile tumor sites were adjacent to organs at risk. CONCLUSIONS:A methodology to obtain 4D-T2w MRI that retrospectively applies the motion information from 4D-T1w MRI to 3-dimensional T2w MRI was developed and verified. Four-dimensional T2w MRI can assist clinicians in delineating mobile lesions that are difficult to define on 4D-T1w MRI, because of poor tumor-tissue contrast.


Invest Radiol


Investigative radiology


Freedman JN,Collins DJ,Bainbridge H,Rank CM,Nill S,Kachelrieß M,Oelfke U,Leach MO,Wetscherek A




Has Abstract


2017-10-01 00:00:00












  • Diatrizoate contrast agents: 2-amino-5-acetamido-, and 3,5-diamino-2,4,6-triiodobenzoates.

    abstract::We have examined the metabolic behavior of several triiodobenzoic acid derivatives because of the observed mutagenicity and cytotoxicity of 3-amino-5-acetamido-2,4,6-triiodobenzoate (I) and 3,5-diamino-2,4,6-triiodobenzoate (II). Measurements were facilitated using iodine-131 (131I)-labeled compounds. Drug retention i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Weiss R,Hsu B,Wheeler L,Norman A,Riley RF

    更新日期:1981-11-01 00:00:00

  • The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.

    abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Dae M,Canhasi B,Botvinick E,Olvera S,Schechtmann N,Engelstad B,Hattner R,Schiller N,O'Connell W,Faulkner D

    更新日期:1985-07-01 00:00:00

  • Free-Breathing Dynamic Contrast-Enhanced Imaging of the Upper Abdomen Using a Cartesian Compressed-Sensing Sequence With Hard-Gated and Motion-State-Resolved Reconstruction.

    abstract:OBJECTIVES:The aim of this study was to compare a compressed-sensing free-breathing VIBE (fbVIBE) with a conventional breath-hold VIBE (bhVIBE) for dynamic contrast-enhanced imaging of the upper abdomen. MATERIALS AND METHODS:In total, 70 datasets (bhVIBE, n = 30; fbVIBE n = 40; hard-gated [hg] reconstruction, n = 30;...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hausmann D,Niemann T,Kreul D,Nocito A,Klarhöfer M,Nickel DM,Kiefer B,Attenberger UI,Zöllner FG,Kubik-Huch RA

    更新日期:2019-11-01 00:00:00

  • Computed Tomography for 4-Dimensional Angiography and Perfusion Imaging of the Prostate for Embolization Planning of Benign Prostatic Hyperplasia.

    abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kobe A,Puippe G,Klotz E,Alkadhi H,Pfammatter T

    更新日期:2019-10-01 00:00:00

  • Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 T.

    abstract:PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Szomolanyi P,Rohrer M,Frenzel T,Noebauer-Huhmann IM,Jost G,Endrikat J,Trattnig S,Pietsch H

    更新日期:2019-09-01 00:00:00

  • Mixing problems of low flow hepatic artery infusion. Improvement with small caliber double lumen balloon catheters.

    abstract::The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Barth KH,Lutz RJ,Kremers PW,Miller DL

    更新日期:1988-07-01 00:00:00

  • Curved reconstructions versus three-dimensional surface rendering in the demonstration of cortical lesions in patients with extratemporal epilepsy.

    abstract:RATIONALE AND OBJECTIVES:To compare the visibility and localization of extratemporal cortical lesions in extratemporal epilepsy by using curved reconstruction (CR) and three-dimensional surface rendering (3D SR) of 3D-acquired MR images and to study the degree of confidence with which localizations are made, particular...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Meiners LC,Scheffers JM,De Kort GA,Burger H,Van Huffelen AC,Van Rijen PC,Van Veelen CW

    更新日期:2001-04-01 00:00:00

  • Personal computer needs for the radiologist.

    abstract::This article reviews the computer system hardware and software, applications programs, and computer network services that are available on microcomputers for use by the radiologist. The American College of Radiology Institute computer network is described, which is specifically designed to help the practicing radiolog...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Newell JD,Hunter TB

    更新日期:1986-02-01 00:00:00

  • Brain tumor enhancement in magnetic resonance imaging: dependency on the level of protein binding of applied contrast agents.

    abstract:PURPOSE:To evaluate the dependency of tumor contrast enhancement (CE) in regard to protein-binding properties of contrast agents, using 4 different agents with a wide range of protein-binding capacities in a standardized rat brain glioma model. MATERIAL AND METHODS:Sixteen rats with implanted brain gliomas were evalua...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Wintersperger BJ,Runge VM,Tweedle MF,Jackson CB,Reiser MF

    更新日期:2009-02-01 00:00:00

  • Noninvasive measurement of an index of renal blood flow.

    abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Powers TA,Rees RS,Bowen RD

    更新日期:1983-07-01 00:00:00

  • AcidoCEST-UTE MRI for the Assessment of Extracellular pH of Joint Tissues at 3 T.

    abstract:OBJECTIVES:The goal of this study was to demonstrate feasibility of measuring extracellular pH in cartilage and meniscus using acidoCEST technique with a 3-dimensional ultrashort echo time readout (acidoCEST-UTE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Magnetization transfer ratio asymmetry, radiofrequ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ma YJ,High RA,Tang Q,Wan L,Jerban S,Du J,Chang EY

    更新日期:2019-09-01 00:00:00

  • Inhibition of restenosis in stented porcine coronary arteries: uptake of Paclitaxel from angiographic contrast media.

    abstract:RATIONALE AND OBJECTIVES:Paclitaxel added to angiographic contrast medium (CM) has been shown to inhibit restenosis in the porcine coronary overstretch model. This study determined early local tissue concentrations after the administration of different paclitaxel doses and preparations. MATERIALS AND METHODS:Fifteen p...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Speck U,Scheller B,Abramjuk C,Grossmann S,Mahnkopf D,Simon O

    更新日期:2004-03-01 00:00:00

  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach: Comparison of 3 Contrast Agents and Recommendation of Feasible Doses.

    abstract:OBJECTIVE:The aims of this study were to compare 3 contrast agents and to define feasible doses for quantitative lung perfusion imaging using the dual-bolus approach in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Ten healthy volunteers (6 males, 4 females; mean age, 23.5 yea...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Veldhoen S,Oechsner M,Fischer A,Weng AM,Kunz AS,Bley TA,Köstler H,Ritter CO

    更新日期:2016-03-01 00:00:00

  • Hepatic kinetics and magnetic resonance imaging of gadolinium-EOB-DTPA in dogs.

    abstract:RATIONALE AND OBJECTIVES:To measure the hepatic uptake and biliary elimination kinetics of gadolinium (Gd)-EOB-DTPA in dogs. METHOD:Two groups of four beagles each were anesthetized and given an intravenous bolus of 25 mumol/kg or 250 mumol/kg of Gd-EOB-DTPA. Blood, hepatic bile, and urine were collected over 140 minu...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Benness G,Khangure M,Morris I,Warwick A,Burrows P,Vogler H,Weinmann HJ

    更新日期:1996-04-01 00:00:00

  • Quantification of roughness of calcific deposits in computed tomography scans of human coronary arteries.

    abstract:OBJECTIVES:The incidence of coronary artery disease has been shown to be greater in patients with calcific deposits than in those without. It has been suggested that the pattern of distribution of coronary calcific deposits within coronary arteries is of greater predictive value for acute coronary events than the overa...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Wilner WT,Mazraeshahi RM,Aboshady I,Bodmann BG,Papadakis M,Kouri D,Conyers JL,Cherukuri P,Vela D,Gladish G,Gavish L,Cody DD,Frazier L,Lukovenkov S,Madjid M,Zarrabi A,Ahmed A,Willerson JT,Casscells SW,Gertz SD

    更新日期:2007-11-01 00:00:00

  • Consistency of rotator-cuff calcifications. Observations on plain radiography, sonography, computed tomography, and at needle treatment.

    abstract:RATIONALE AND OBJECTIVES:The author analyzes findings of consistency of rotator-cuff calcifications found at ultrasound (US)-guided needle treatment compared with findings of plain radiography, US, and computed tomography (CT). METHODS:Twenty patients had rotator-cuff calcifications (mean diameter, 1.5 cm; range, 1.1-...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Farin PU

    更新日期:1996-05-01 00:00:00

  • Granulocyte accumulation in the transplanted liver does not correlate with clinical and histologic evidence of dysfunction.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared fro...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ziser A,Forstrom LA,Plevak DJ,Sanchez-Urdazpal L,Gores GJ,Wiesner RH,Batts KP,Krom RA

    更新日期:1996-03-01 00:00:00

  • Radiologist's responsibility in France when using contrast media.

    abstract::French physicians must obtain their patient's consent before carrying out an action that interferes with the patient's corporal integrity. The doctor must use simple, approximate, intelligent, and honest words that help the patient to reach the indispensable decision. Proof of lack of consent lies with the patient. Th...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Alméras JP,Husson R,Moreau JF

    更新日期:1988-09-01 00:00:00

  • Sclerotherapy of the gallbladder in pigs. Development of a balloon catheter for a single-step procedure.

    abstract::Gallbladder sclerotherapy after permanent cystic duct occlusion, to prevent gallstone recurrence in nonsurgical gallstone therapy, is at least a two-stage procedure. A balloon catheter was developed to perform gallbladder sclerotherapy with only temporary occlusion of the cystic duct, and the efficacy and safety of th...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Brakel K,Laméris JS,Vergunst H,Ten Kate FJ,Nijs HG,Terpstra OT

    更新日期:1991-09-01 00:00:00

  • Phantom testing of peripheral artery. Absolute blood flow measurement with digital arteriography.

    abstract::A technique to measure absolute arterial blood flow in ml/min has been developed utilizing software programs with high-speed digital recording for the off-line analysis of intra-arterial injections of contrast medium. Measurements of pulsatile flow in a phantom for a physical flow model showed that calculations with t...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Forbes G,Gray JE,Felmlee JP

    更新日期:1985-03-01 00:00:00

  • Toward clinical X-ray phase-contrast CT: demonstration of enhanced soft-tissue contrast in human specimen.

    abstract:OBJECTIVES:X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a convent...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Donath T,Pfeiffer F,Bunk O,Grünzweig C,Hempel E,Popescu S,Vock P,David C

    更新日期:2010-07-01 00:00:00

  • Activities of the Conjoint Committee. Enhancement of diagnostic radiologic research and education.

    abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Putman CE,Frank JA

    更新日期:1993-04-01 00:00:00

  • High-resolution magnetic resonance imaging at 2 Tesla: potential for atherosclerotic lesions exploration in the apolipoprotein E knockout mouse.

    abstract:INTRODUCTION:The aim of the present study was to evaluate the potential of high-resolution MRI at 2 Tesla (T) for direct noninvasive imaging of the aortic wall in a mouse model of atherosclerosis. MATERIAL AND METHODS:A specific mouse antenna was developed and sequence parameters were adjusted. T(1)- and T2-weighted i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Chaabane L,Soulas EC,Contard F,Salah A,Guerrier D,Briguet A,Douek P

    更新日期:2003-08-01 00:00:00

  • Pulmonary density distribution in experimental noncardiac canine pulmonary edema evaluated by computed transmission tomography.

    abstract::We evaluated the density distribution (anterior-posterior) of the right lung in 19 acutely anesthetized supine dogs using computed transmission tomography (CTT). Eleven dogs served as controls, and eight received 0.12 cc/kg of intravenously administered oleic acid. The latter were sequentially imaged over 1 hour. Nine...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Slutsky RA,Long S,Peck WW,Higgins CB,Mattrey R

    更新日期:1984-05-01 00:00:00

  • Magnetic resonance pulmonary angiography and direct imaging of embolus for the detection of pulmonary emboli.

    abstract:RATIONALE AND OBJECTIVES:The authors developed a two-dimensional breathhold magnetic resonance (MR) technique for the direct imaging of pulmonary emboli. METHODS:In vitro MR imaging was performed to demonstrate the potential generation of clot-blood contrast by in vivo pulmonary embolism (PE). A two-dimensional magnet...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Moody AR,Liddicoat A,Krarup K

    更新日期:1997-08-01 00:00:00

  • Heavily Calcified Coronary Arteries: Advanced Calcium Subtraction Improves Luminal Visualization and Diagnostic Confidence in Dual-Energy Coronary Computed Tomography Angiography.

    abstract:OBJECTIVES:The aim of this study was to evaluate a prototype dual-energy computed tomography calcium subtraction algorithm and its impact on luminal visualization in patients with heavily calcified coronary arteries. MATERIALS AND METHODS:Twenty-nine patients (62% male; mean age, 64 ± 7 years) who had undergone dual-e...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: De Santis D,Jin KN,Schoepf UJ,Grant KL,De Cecco CN,Nance JW Jr,Vogl TJ,Laghi A,Albrecht MH

    更新日期:2018-02-01 00:00:00

  • The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation, and vascularization.

    abstract:OBJECTIVES AND RATIONALE:Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ni Y,Marchal G,Zhang X,Van Hecke P,Michiels J,Yu J,Rummeny E,Lodemann KP,Baert AL

    更新日期:1993-06-01 00:00:00

  • Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

    abstract::An agent has been identified in lymph from rat kidneys rendered ischemic by partial renal artery occlusion that induces a striking neovascular response in a hamster cheek-pouch assay system. The factor has a high molecular weight, cannot be identified in lymph from normal kidneys, and is associated with a marked incre...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hollenberg NK,Paskins-Hurlburt AJ,Abrams HL

    更新日期:1985-01-01 00:00:00

  • Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.

    abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

    更新日期:2020-03-01 00:00:00

  • Safety and Oncologic Outcomes of Magnetic Resonance Imaging-Guided Cryoablation of Renal Cell Carcinoma: A 10-Year Single-Center Experience.

    abstract:OBJECTIVES:Magnetic resonance imaging guidance has been sporadically reported for renal tumor cryoablation (CA); therefore, clinical experience with this modality is still limited.The aim of this study is to retrospectively analyze our 10-year experience with renal tumor CA performed on a 1.5 T magnetic resonance imagi...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cazzato RL,De Marini P,Leonard-Lorant I,Leclerc L,Auloge P,Tricard T,Dalili D,Garnon J,Lang H,Gangi A

    更新日期:2020-09-04 00:00:00