Altered cerebrovenous drainage in patients with migraine as assessed by phase-contrast magnetic resonance imaging.

Abstract:

OBJECTIVE:We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). METHODS:We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age- and gender-matched controls with no neurologic disease (37.3 ± 13.7 years) on a 3 Tesla MR scanner. A 2D time-of-flight MR-venography of the upper neck region was performed to visualize the venous vasculature. Cine-phase contrast scans with high-velocity encoding were employed to quantify arterial inflow and flow in the primary venous channels (right and left jugular veins), whereas scans with low-velocity encoding were employed to quantify flow in the secondary venous channels (epidural, vertebral, and deep cervical veins). RESULTS:Patients with migraine showed (i) a higher prevalence of dense secondary extracranial venous networks (15 vs. 2, P = 0.00002) and (ii) a significantly larger percentage of venous outflow through secondary channels (10.5% vs. 5.5%; of total cerebral blood flow, P = 0.02). This mainly included drainage through epidural, vertebral, and deep cervical veins. CONCLUSION:Migraine patients showed a significantly larger percentage of venous outflow through secondary channels. The mechanism of this alteration remains to be elucidated. Potential mechanisms include repeated release of vasoactive substances or growth factors.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Koerte IK,Schankin CJ,Immler S,Lee S,Laubender RP,Grosse C,Eftimov L,Milde-Busch A,Reiser M,Straube A,Heinen F,Alperin N,Ertl-Wagner B

doi

10.1097/RLI.0b013e318210ecf5

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

434-40

issue

7

eissn

0020-9996

issn

1536-0210

journal_volume

46

pub_type

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