High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol.


OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-based contrast agent gadobutrol. MATERIALS AND METHODS:Thirty patients who had received at least 5 MRI examinations (plus an additional last MRI for reference) with the exclusive use of gadobutrol, resulting in a total cumulative dose of 54.1 ± 30.4 mL gadobutrol, were analyzed retrospectively. Signal intensity ratio differences were calculated for DN-to-pons, DN-to-CSF, and GP-to-thalamus ratios by subtracting the SI ratio at the first MRI from the SI ratio at the last MRI scan. One-sample t tests were employed to examine if they differed from 0. Regression and correlational analyses were performed to examine whether the SI ratio differences were predicted by a number of control variables. RESULTS:Signal intensity ratio differences did not differ significantly from 0, neither for the DN-to-pons ratio (-0.0035 ± 0.0476, P = 0.69), the DN-to-CSF ratio (-0.0539 ± 0.3217, P = 0.37), nor the GP-to-thalamus ratio (-0.0020 ± 0.0211, P = 0.60). None of the control variables predicted changes in SI ratios. CONCLUSIONS:In contrast to a recently published study, we did not find signal increases in the DN or in the GP after serial injections of gadobutrol, even though the total dose applied here was considerably larger than in the respective study. This finding adds further support to the hypothesis that the molecular structure of a gadolinium-based contrast agent as either macrocyclic or linear is a crucial factor for its potential to cause gadolinium deposition in the brain. Future studies should further assess this hypothesis by additional animal investigations as well as histopathological and clinical correlation studies.


Invest Radiol


Investigative radiology


Radbruch A,Weberling LD,Kieslich PJ,Hepp J,Kickingereder P,Wick W,Schlemmer HP,Bendszus M




Has Abstract


2015-12-01 00:00:00












  • Role of iodinated contrast material in the evaluation of myocardial infarction by computerized transmission tomography.

    abstract::In vivo and in vitro studies have shown that areas of myocardial infarctions can be delineated on CT scans after intravenous administration of iodinated contrast material to dogs with experimental myocardial infarctions. Within the first minute after intravenous administration of contrast material (initial myocardial ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Higgins CB,Siemers PT,Newell JD,Schmidt W

    更新日期:1980-11-01 00:00:00

  • Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model.

    abstract:OBJECTIVE:The purpose of this study was to assess the ability of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold standard. MATERIALS AND METHODS...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Artz NS,Wentland AL,Sadowski EA,Djamali A,Grist TM,Seo S,Fain SB

    更新日期:2011-02-01 00:00:00

  • Preliminary evaluation of Hexabrix for temporomandibular joint arthrography.

    abstract::A double-blind randomized study of ten patients compared Hexabrix 32% to Renografin-60 in TMJ arthrography. Equivalent volumes of contrast material were injected under fluoroscopic observation, with film quality and patient subjective response graded independently by three radiologists. In immediate arthrogram quality...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章


    authors: Katzberg RW

    更新日期:1984-11-01 00:00:00

  • Digital mammography using iodine-based contrast media: initial clinical experience with dynamic contrast medium enhancement.

    abstract:PURPOSE:We sought to evaluate the potential of dynamic contrast enhancement after the intravenous administration of an iodine-based contrast medium in full-field digital mammography. MATERIAL AND METHODS:A protocol for image acquisition was established for contrast-enhanced mammography and the mammography unit (Senogr...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Diekmann F,Diekmann S,Jeunehomme F,Muller S,Hamm B,Bick U

    更新日期:2005-07-01 00:00:00

  • Attenuation correction for flexible magnetic resonance coils in combined magnetic resonance/positron emission tomography imaging.

    abstract:INTRODUCTION:Attenuation correction for magnetic resonance (MR) coils is a new challenge that came about with the development of combined MR and positron emission tomography (PET) imaging. This task is difficult because such coils are not directly visible on either PET or MR acquisitions with current combined scanners ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Eldib M,Bini J,Calcagno C,Robson PM,Mani V,Fayad ZA

    更新日期:2014-02-01 00:00:00

  • Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.

    abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

    更新日期:2020-03-01 00:00:00

  • Relative carotid blood flow measurements in dogs by high-speed CT. A preliminary study.

    abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ringertz HG,Jaschke W,Sievers R,Lipton MJ

    更新日期:1987-12-01 00:00:00

  • Facilitated Diagnosis of Pneumothoraces in Newborn Mice Using X-ray Dark-Field Radiography.

    abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of x-ray dark-field imaging in projection radiography-based depiction of pneumothoraces in the neonatal murine lung, a potentially life-threatening medical condition that requires a timely and correct diagnosis. MATERIALS AND METHODS:By the use of a ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hellbach K,Yaroshenko A,Willer K,Pritzke T,Baumann A,Hesse N,Auweter S,Reiser MF,Eickelberg O,Pfeiffer F,Hilgendorff A,Meinel FG

    更新日期:2016-10-01 00:00:00

  • The importance of nuclear magnetic relaxation dispersion (NMRD) profiles in MRI contrast media development.

    abstract::Observation of the relaxivity of MRI contrast media over a wide range of magnetic fields is not only necessary for predicting their efficiency at any field but also compulsory for understanding and improving their mechanisms of action. The best experimental approach to this problem is the field cycling method, which a...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Muller RN,Vander Elst L,Rinck PA,Vallet P,Maton F,Fischer H,Roch A,Van Haverbeke Y

    更新日期:1988-09-01 00:00:00

  • New contrast media designed for x-ray energy subtraction imaging in digital mammography.

    abstract:RATIONALE AND OBJECTIVES:In contrast-enhanced dual-energy subtraction imaging 2 images acquired postcontrast media administration at different energies are subtracted to highlight structures hidden in the absence of contrast media. X-ray spectra of the newly developed digital full-field mammography units (GE Senographe...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Lawaczeck R,Diekmann F,Diekmann S,Hamm B,Bick U,Press WR,Schirmer H,Schön K,Weinmann HJ

    更新日期:2003-09-01 00:00:00

  • Contrast media-induced chromosomal damage in human lymphocyte cultures.

    abstract::Ionic (diatrizoate, ioxaglate) and nonionic (iohexol, iosimide, iopromide, and iotrolan) contrast media (CM) were evaluated for their cytogenetic effects in lymphocytes. Heparinized blood was mixed with culture medium RPMI-1640 supplemented with phytohemagglutinin, fetal calf serum, and antibiotics. Plastic tubes cont...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Parvez Z,Kormano M,Moncada R,Eklund R

    更新日期:1986-11-01 00:00:00

  • Quantification of roughness of calcific deposits in computed tomography scans of human coronary arteries.

    abstract:OBJECTIVES:The incidence of coronary artery disease has been shown to be greater in patients with calcific deposits than in those without. It has been suggested that the pattern of distribution of coronary calcific deposits within coronary arteries is of greater predictive value for acute coronary events than the overa...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Wilner WT,Mazraeshahi RM,Aboshady I,Bodmann BG,Papadakis M,Kouri D,Conyers JL,Cherukuri P,Vela D,Gladish G,Gavish L,Cody DD,Frazier L,Lukovenkov S,Madjid M,Zarrabi A,Ahmed A,Willerson JT,Casscells SW,Gertz SD

    更新日期:2007-11-01 00:00:00

  • Investigation of 125I as an isotopic source for mammography.

    abstract::An isotopic radiation source 125I was investigated for use in soft tissue radiaography, with particular attention to possible use in mammography for mass screening. Film sensitivities, exposure rates, absorbed doeses, contrast and resolution were determined, and compared to conventional x-ray units. It was found that ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Fairchild R,Atkins HL,Lebowitz E,Greenberg D

    更新日期:1975-09-01 00:00:00

  • Bone mineral analysis using single-energy computed tomography.

    abstract::We present a new method for evaluating in vivo changes in bone mineralization in the peripheral skeleton, using computed tomography (CT). A set of bone mineralization indices are generated from numerous CT images of the patient's distal radius. The cross-sectional anatomy displayed by the CT scan allows for separate e...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Orphanoudakis SC,Jensen PS,Rauschkolb EN,Lang R,Rasmussen H

    更新日期:1979-03-01 00:00:00

  • Effects of iodinated x-ray contrast media on renal epithelial cells in culture.

    abstract:RATIONALE AND OBJECTIVES:To study cellular mechanisms that cause contrast media nephropathy, an in vitro system for proximal and distal tubular cells has been established to evaluate the influence of x-ray contrast media on tubular function. METHODS:Confluent cell cultures of the two renal cell lines, proximal tubule ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Andersen KJ,Christensen EI,Vik H

    更新日期:1994-11-01 00:00:00

  • Breast stereotactic core biopsy washings: abundant cell samples from clinically occult lesions for flow cytometric DNA analysis.

    abstract:RATIONALE AND OBJECTIVES:The object of this study was to determine by flow cytometry the cellular and DNA content of the washings of core biopsy samples and needles obtained during stereotactic core biopsies of clinically occult suspicious lesions. METHODS:Fourteen-gauge core multipass biopsy inner-needle saline washi...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Stomper PC,Budnick RM,Stewart CC

    更新日期:1998-01-01 00:00:00

  • Activities of the Conjoint Committee. Enhancement of diagnostic radiologic research and education.

    abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Putman CE,Frank JA

    更新日期:1993-04-01 00:00:00

  • Thirty-two-channel coil 3T magnetic resonance-guided biopsies of prostate tumor suspicious regions identified on multimodality 3T magnetic resonance imaging: technique and feasibility.

    abstract:OBJECTIVES:To test the technique and feasibility of translating tumor suspicious region maps in the prostate, obtained by multimodality, anatomic, and functional 3T magnetic resonance imaging (MRI) data to 32-channel coil, T2-weighted (T2-w), 3T MR images, for directing MR-guided biopsies. Furthermore, to evaluate the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hambrock T,Fütterer JJ,Huisman HJ,Hulsbergen-vandeKaa C,van Basten JP,van Oort I,Witjes JA,Barentsz JO

    更新日期:2008-10-01 00:00:00

  • Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract.

    abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章


    authors: Johansen JG

    更新日期:1978-11-01 00:00:00

  • Timing and magnitude of the postural effect on the distribution of pulmonary blood flow.

    abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kuribayashi S,Garnic JD,Abrams HL

    更新日期:1982-11-01 00:00:00

  • Acquired cystic disease of the kidneys. Computed tomography and ultrasonography appraisal in patients on peritoneal and hemodialysis.

    abstract::Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Jabour BA,Ralls PW,Tang WW,Boswell WD Jr,Colletti PM,Feinstein EI,Massry SG

    更新日期:1987-09-01 00:00:00

  • Effects of dilating the canine pulmonary annulus with two balloons. Doppler ultrasound and postmortem findings.

    abstract::Simultaneous inflation of two balloons may be necessary for balloon dilation valvuloplasty in patients with a large annulus. We examined the cardiovascular effects of dilating the pulmonary annulus with two balloons in 18 normal dogs using pulsed Doppler ultrasound and gross and microscopic examination. When the ratio...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Butto F,Burke B,Berry JM,Amplatz K,Bass JL

    更新日期:1988-08-01 00:00:00

  • Extravascular extravasation of radiographic contrast media. Effects of conventional and low-osmolar agents in the rat thigh.

    abstract::We compared the damage resulting from intradermal injection of four commonly used radiographic contrast media in laboratory rats. Sixty percent meglumine diatrizoate (Reno M 60) and ioxaglate (Hexabrix) produced significantly more ulceration and crusting on gross inspection and more necrosis, edema, and hemorrhage on ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cohan RH,Leder RA,Bolick D,Herzberg AJ,Hedlund LW,Wheeler CT,Helms MJ,Dunnick NR

    更新日期:1990-05-01 00:00:00

  • A preliminary study of MRI quantification of simulated calcified pulmonary nodules.

    abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gamsu G,de Geer G,Cann C,Müller N,Brito A

    更新日期:1987-11-01 00:00:00

  • Radiologist's responsibility in France when using contrast media.

    abstract::French physicians must obtain their patient's consent before carrying out an action that interferes with the patient's corporal integrity. The doctor must use simple, approximate, intelligent, and honest words that help the patient to reach the indispensable decision. Proof of lack of consent lies with the patient. Th...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Alméras JP,Husson R,Moreau JF

    更新日期:1988-09-01 00:00:00

  • Whole-body diffusion-weighted imaging with apparent diffusion coefficient mapping for treatment response assessment in patients with diffuse large B-cell lymphoma: pilot study.

    abstract:OBJECTIVES:The aim of this pilot study was to assess post-treatment apparent diffusion coefficient (ADC) changes of diffuse large B-cell lymphoma lesions on respiratory-gated whole-body diffusion-weighted imaging (DWI), with integrated (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Lin C,Itti E,Luciani A,Zegai B,Lin SJ,Kuhnowski F,Pigneur F,Gaillard I,Paone G,Meignan M,Haioun C,Rahmouni A

    更新日期:2011-05-01 00:00:00

  • Pyelovenous and pyelolymphatic backflow during retrograde pyelography in renal vein thrombosis.

    abstract::Pyelovenous and pyelolymphatic backflow have been observed during retrograde pyelography in three patients with renal vein thrombosis. The radiographic patterns of backflow following experimental unilateral renal vein occlusion in rabbits were analyzed and correlated with the clinical findings. Capsular, perihilar, pe...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Bidgood WD Jr,Cuttino JT Jr,Clark RL,Volberg FM

    更新日期:1981-01-01 00:00:00

  • Evaluation of complex joint motion with computer-based analysis of fluoroscopic sequences.

    abstract:RATIONALE AND OBJECTIVES:To develop a computer-assisted analysis of complex joint motion based on standard fluoroscopic sequences. MATERIALS AND METHODS:Fluoroscopic sequences of 10 normal shoulders and 20 patients after total shoulder arthroplasty were recorded during abduction and adduction. The analysis of the shou...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Pfirrmann CW,Huser M,Székely G,Hodler J,Gerber C

    更新日期:2002-02-01 00:00:00

  • Cerebral computed tomography angiography using a low tube voltage (80 kVp) and a moderate concentration of iodine contrast material: a quantitative and qualitative comparison with conventional computed tomography angiography.

    abstract:OBJECTIVE:To investigate the feasibility of an 80-kVp protocol using a moderate concentration contrast material (MC-CM) for cerebral computed tomography angiography by comparison with a conventional 120-kVp protocol using a high concentration contrast material (HC-CM). MATERIALS AND METHODS:Attenuation values and sign...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cho ES,Chung TS,Oh DK,Choi HS,Suh SH,Lee HK,Lee KH

    更新日期:2012-02-01 00:00:00

  • Low tube voltage improves computed tomography imaging of delayed myocardial contrast enhancement in an experimental acute myocardial infarction model.

    abstract:OBJECTIVE:We sought to evaluate the influence of tube voltage on the visualization of acute myocardial infarction (MI) in cardiac multislice spiral computed tomography (MSCT). MATERIALS AND METHODS:Acute MI was induced in 12 domestic pigs by a 45-minute balloon occlusion of the left anterior descending artery. Delayed...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Mahnken AH,Bruners P,Mühlenbruch G,Emmerich M,Hohl C,Günther RW,Wildberger JE

    更新日期:2007-02-01 00:00:00