High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol.


OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-based contrast agent gadobutrol. MATERIALS AND METHODS:Thirty patients who had received at least 5 MRI examinations (plus an additional last MRI for reference) with the exclusive use of gadobutrol, resulting in a total cumulative dose of 54.1 ± 30.4 mL gadobutrol, were analyzed retrospectively. Signal intensity ratio differences were calculated for DN-to-pons, DN-to-CSF, and GP-to-thalamus ratios by subtracting the SI ratio at the first MRI from the SI ratio at the last MRI scan. One-sample t tests were employed to examine if they differed from 0. Regression and correlational analyses were performed to examine whether the SI ratio differences were predicted by a number of control variables. RESULTS:Signal intensity ratio differences did not differ significantly from 0, neither for the DN-to-pons ratio (-0.0035 ± 0.0476, P = 0.69), the DN-to-CSF ratio (-0.0539 ± 0.3217, P = 0.37), nor the GP-to-thalamus ratio (-0.0020 ± 0.0211, P = 0.60). None of the control variables predicted changes in SI ratios. CONCLUSIONS:In contrast to a recently published study, we did not find signal increases in the DN or in the GP after serial injections of gadobutrol, even though the total dose applied here was considerably larger than in the respective study. This finding adds further support to the hypothesis that the molecular structure of a gadolinium-based contrast agent as either macrocyclic or linear is a crucial factor for its potential to cause gadolinium deposition in the brain. Future studies should further assess this hypothesis by additional animal investigations as well as histopathological and clinical correlation studies.


Invest Radiol


Investigative radiology


Radbruch A,Weberling LD,Kieslich PJ,Hepp J,Kickingereder P,Wick W,Schlemmer HP,Bendszus M




Has Abstract


2015-12-01 00:00:00












  • Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

    abstract::An agent has been identified in lymph from rat kidneys rendered ischemic by partial renal artery occlusion that induces a striking neovascular response in a hamster cheek-pouch assay system. The factor has a high molecular weight, cannot be identified in lymph from normal kidneys, and is associated with a marked incre...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hollenberg NK,Paskins-Hurlburt AJ,Abrams HL

    更新日期:1985-01-01 00:00:00

  • Relative carotid blood flow measurements in dogs by high-speed CT. A preliminary study.

    abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ringertz HG,Jaschke W,Sievers R,Lipton MJ

    更新日期:1987-12-01 00:00:00

  • Influence of clinical history upon detection of nodules and other lesions.

    abstract::The authors reexamined a suspected difference in the effects of clinical information upon detection of nodules vs. more diverse lesions by directly incorporating classification specificity into detection ROC analysis. Categorical prompts, correct for specific abnormalities, led to detection superior to unprompted read...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Berbaum KS,Franken EA Jr,Dorfman DD,Barloon TJ

    更新日期:1988-01-01 00:00:00

  • Evaluation of radiologist interpretive performance using blinded reads by multiple external readers.

    abstract:OBJECTIVE:To demonstrate a method of assessing radiologic diagnostic agreement utilizing multiple blinded external readers. METHODS:Six body CT studies interpreted by one reader (primary reader) at the host institution were compiled with patient identifiers removed. Brief clinical histories that were available to the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Ryan AF,Semelka RC,Molina PL,Yonkers S,Vaidean G

    更新日期:2010-04-01 00:00:00

  • Ultrasonic detection of osteomyelitis. Pathologic correlation in an animal model.

    abstract::The authors correlated sonographic findings with histologic findings in a rabbit model of osteomyelitis. Staphylococcus aureus osteomyelitis was induced in the femora of 11 New Zealand white rabbits. The opposite leg was used as a control. Sonographic findings showed fluid adjacent to the bone in 11 cases. The fluid w...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Abiri MM,DeAngelis GA,Kirpekar M,Abou AN,Ablow RC

    更新日期:1992-02-01 00:00:00

  • Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion.

    abstract:OBJECTIVES:Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. MATERIAL AND METHODS:After induction of hepatic ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Choukèr A,Lizak M,Schimel D,Helmberger T,Ward JM,Despres D,Kaufmann I,Bruns C,Löhe F,Ohta A,Sitkovsky MV,Klaunberg B,Thiel M

    更新日期:2008-02-01 00:00:00

  • Spontaneous acute dissection of the internal carotid artery: high-resolution magnetic resonance imaging at 3.0 tesla with a dedicated surface coil.

    abstract:PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Bachmann R,Nassenstein I,Kooijman H,Dittrich R,Kugel H,Niederstadt T,Kuhlenbäumer G,Ringelstein EB,Krämer S,Heindel W

    更新日期:2006-02-01 00:00:00

  • Correlation of Histological Vessel Characteristics and Diffusion-Weighted Imaging Intravoxel Incoherent Motion-Derived Parameters in Pancreatic Ductal Adenocarcinomas and Pancreatic Neuroendocrine Tumors.

    abstract:OBJECTIVE:To investigate the correlation between intravoxel incoherent motion (IVIM) model-derived parameters and histologically determined microvascularity in pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:From April 2013 to May 2014, 42 patients with mal...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Klau M,Mayer P,Bergmann F,Maier-Hein K,Hase J,Hackert T,Kauczor HU,Grenacher L,Stieltjes B

    更新日期:2015-11-01 00:00:00

  • Comprehensive assessment of renal function and vessel morphology in potential living kidney donors: an MRI-based approach.

    abstract:OBJECTIVES:To test the feasibility of a single MR-based examination allowing for the comprehensive assessment of renal anatomy, function, and vascular status in candidates for kidney transplantation. MATERIALS AND METHODS:Twelve healthy potential kidney donors (mean age: 47 +/- 14 [standard deviation] years, 3 men and...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章


    authors: Rossi C,Boss A,Artunc F,Yildiz S,Martirosian P,Dittmann H,Claussen CD,Heyne N,Schick F,Schlemmer HP

    更新日期:2009-11-01 00:00:00

  • An experimental evaluation of central vs. peripheral injection for intravenous digital subtraction angiography (IV-DSA).

    abstract::At a given radiation dosage and field of view, five variables are under meaningful control for intravenous digital subtraction angiography (IV-DSA): concentration and quantity of contrast media injected, volume of injectate, rate of injection, and site of injection. Some controversy exists regarding the selection of a...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Rubin DL,Burbank FH,Bradley BR,Brody WR

    更新日期:1984-01-01 00:00:00

  • Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine.

    abstract:OBJECTIVE:To determine the prevalence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) who have received gadopentetate dimeglumine. MATERIALS AND METHODS:We retrospectively studied all patients who underwent contrast-enhanced magnetic resonance imagings (CE-MRIs) between January 1, ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hope TA,Herfkens RJ,Denianke KS,LeBoit PE,Hung YY,Weil E

    更新日期:2009-03-01 00:00:00

  • Experimental carotid aneurysms: I. Simple surgical production and radiographic evaluation.

    abstract::Using simple surgical techniques, experimental carotid aneurysms are created which simulate some types of human berry aneurysms, both in hemodynamic and radiographic behavior. End to side anastomoses of an external jugular vein graft to the common carotid artery can be carried out by radiologic personnel with no forma...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kerber CW,Buschman RW

    更新日期:1977-03-01 00:00:00

  • Automated calibration in vascular X-ray images using the accurate localization of catheter marker bands.

    abstract:RATIONALE AND OBJECTIVES:To develop a new automated calibration method for vessel measurements in vascular x-ray images. METHODS:Radiopaque marker bands mounted equidistantly on a small catheter were acquired in vitro at five image intensifier (II) sizes in x-ray projection images. The positions of the marker centers ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Van Assen HC,Vrooman HA,Egmont-Petersen M,Bosch HG,Koning G,Van Der Linden EL,Goedhart B,Reiber JH

    更新日期:2000-04-01 00:00:00

  • Saturation kinetics of iopanoate in dogs with an intact enterohepatic circulation. Before and after phenobarbital induction.

    abstract::Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Herzog RJ,Nelson JA,Staubus AE

    更新日期:1976-01-01 00:00:00

  • The detection of inflammation in collapsed lung by alterations in proton nuclear magnetic relaxation times.

    abstract::The purpose of this study was to establish the proton NMR relaxation times of collapsed but otherwise normal lung tissue and to determine whether an inflammatory process within a collapsed lung can be detected by alterations in relaxation times. The lungs of three groups of rabbits were studied: group A (n = 7) had a ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Huber DJ,Kobzik L,Melanson G,Adams DF

    更新日期:1985-08-01 00:00:00

  • Cerebral computed tomography angiography using a low tube voltage (80 kVp) and a moderate concentration of iodine contrast material: a quantitative and qualitative comparison with conventional computed tomography angiography.

    abstract:OBJECTIVE:To investigate the feasibility of an 80-kVp protocol using a moderate concentration contrast material (MC-CM) for cerebral computed tomography angiography by comparison with a conventional 120-kVp protocol using a high concentration contrast material (HC-CM). MATERIALS AND METHODS:Attenuation values and sign...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cho ES,Chung TS,Oh DK,Choi HS,Suh SH,Lee HK,Lee KH

    更新日期:2012-02-01 00:00:00

  • MR characterization of mild hyperthermia-induced gadodiamide release from thermosensitive liposomes in solid tumors.

    abstract:OBJECTIVES:Thermal dose in tumor tissue is a key factor for regional hyperthermia (HT) combined with chemotherapy and for drug delivery using thermosensitive liposomes (TSL). It influences therapy outcome, affects the accumulation of liposomes, and triggers the content release from TSL in the target tissue. For the dev...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Peller M,Schwerdt A,Hossann M,Reinl HM,Wang T,Sourbron S,Ogris M,Lindner LH

    更新日期:2008-12-01 00:00:00

  • Transverse ligament and its effect on meniscal motion. Correlation of kinematic MR imaging and anatomic sections.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the effect of the transverse ligament on translation of the menisci. METHODS:Six cadaveric knees were examined by MR imaging inside a positioning device before and after transecting the transverse ligament. The knees were examined at various positions: extension, 30 degrees of flex...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Muhle C,Thompson WO,Sciulli R,Pedowitz R,Ahn JM,Yeh L,Clopton P,Haghighi P,Trudell DJ,Resnick D

    更新日期:1999-09-01 00:00:00

  • A computer program for the localization of small areas in roentgenological images.

    abstract::A method and associated algorithm are presented which allow a simple and accurate determination to be made of the location of small symmetric areas presented in roentgenological images. The method utilizes an operator to visually spot object positions but eliminates the need for critical positoning accuracy on the ope...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Keller RA,Baily NA

    更新日期:1976-03-01 00:00:00

  • Comparison of open- and closed-chest canine model for quantification of coronary stenosis severity by myocardial contrast echocardiography.

    abstract:RATIONALE AND OBJECTIVES:The objective of the present study was to compare the data regarding the ability of real-time myocardial contrast echocardiography (MCE) to assess altered myocardial blood flow produced by graded coronary stenoses between open- and closed-chest canine models. MATERIALS AND METHODS:Three grades...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Masugata H,Peters B,Lafitte S,Yao B,Strachan M,Ling Kwan O,Ohmori K,Mizushige K,Kohno M

    更新日期:2003-01-01 00:00:00

  • Correlation of flow velocity measurements by magnetic resonance phase contrast imaging and intravascular Doppler ultrasound.

    abstract:RATIONALE AND OBJECTIVES:The authors compare the magnetic resonance (MR) phase contrast flow velocity measurements in varying concentric stenoses with invasive measurements obtained with a Doppler guidewire. METHODS:Flow velocity measurements were obtained using a calibrated 0.018 inch 12 MHz Doppler guidewire and a 1...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hoppe M,Heverhagen JT,Froelich JJ,Kunisch-Hoppe M,Klose KJ,Wagner HJ

    更新日期:1998-08-01 00:00:00

  • Accuracy of ultrasound in fetal femur length determination. Ultrasound phantom study.

    abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gamba JL,Bowie JD,Dodson WC,Hedlund LW

    更新日期:1985-05-01 00:00:00

  • Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the extent to which various commercially available gadolinium-containing contrast-enhancing (CE) agents can interfere with the measurement of calcium levels by currently used laboratory methods, suggesting (spurious) hypocalcemia or hypercalcemia with a potential ris...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Löwe A,Balzer T,Hirt U

    更新日期:2005-08-01 00:00:00

  • Assessment of large bowel motility by cine magnetic resonance imaging using two different prokinetic agents: a feasibility study.

    abstract:OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol c...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Buhmann S,Kirchhoff C,Wielage C,Mussack T,Reiser MF,Lienemann A

    更新日期:2005-11-01 00:00:00

  • Experimental tissue damage after subcutaneous injection of water soluble contrast media.

    abstract::Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kim SH,Park JH,Kim YI,Kim CW,Han MC

    更新日期:1990-06-01 00:00:00

  • Mechanical and biochemical cardiac disturbances induced by bolus administration of iodinated contrast media and noniodinated solutions.

    abstract:RATIONALE AND OBJECTIVES:Bolus injection of iodinated contrast media has been observed to alter myocardial mechanical function, but the consequences on cellular metabolism are poorly documented. Modifications of metabolic parameters (intracellular pH as well as adenosine triphosphate [ATP], phosphocreatine, and inorgan...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Goossens A,Vander Elst L,Van Haverbeke Y,Muller RN

    更新日期:1995-01-01 00:00:00

  • The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.

    abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Dae M,Canhasi B,Botvinick E,Olvera S,Schechtmann N,Engelstad B,Hattner R,Schiller N,O'Connell W,Faulkner D

    更新日期:1985-07-01 00:00:00

  • Diminished cerebrospinal fluid beta-endorphin concentration in monkeys with arachnoiditis.

    abstract::Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Lipman BT,Haughton VM

    更新日期:1988-03-01 00:00:00

  • Magnetic resonance imaging-controlled laser-induced interstitial thermotherapy.

    abstract:RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gewiese B,Beuthan J,Fobbe F,Stiller D,Müller G,Böse-Landgraf J,Wolf KJ,Deimling M

    更新日期:1994-03-01 00:00:00

  • The biliary and urinary excretion of sodium tyropanoate and sodium ipodate in dogs: pharmacokinetics, influence of bile salts and choleretic effects with comparison to iopanoic acid.

    abstract::The biliary and urinary excretion of sodium tyropanoate (Bilopaque) and sodium ipodate (Oragrafin) were studied in unanesthetized bile-fistula dogs using stepwise, increasing, intravenous infusions of the contrast materials. A constant intravenous infusion of sodium taurocholate was administered at the rate of either ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Berk RN,Loeb PM,Cobo-Frenkel A,Barnhart JL

    更新日期:1977-01-01 00:00:00