The radiation dosimetry and normal value study of 99mTc-HMPAO-labeled leukocytes.

Abstract:

RATIONALE AND OBJECTIVES:Indium-111 (111In)-labeled leukocyte scanning has been used frequently in patients suspected of having infections. Recently, technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) has been used to label leukocytes. This study was undertaken to determine the distribution and dosimetry of 99mTc-HMPAO leukocytes in healthy subjects. METHODS:Five healthy volunteers had leukocytes labeled with 99mTc-HMPAO. After injection of the labeled leukocytes, whole body images and blood and urine samples were obtained at multiple time points. RESULTS:Visual interpretation of the images demonstrated significant bowel activity as early as 2 hours and increasing with time such that one the 8- and 24-hour images, the amount of bowel activity would preclude using 99mTc-HMPAO leukocyte scanning for abdominal processes. The dosimetry for this study is similar to that of other studies and is in an acceptable diagnostic range. CONCLUSIONS:99mTc-HMPAO leukocyte studies are an acceptable alternative to 111In-labeled leukocyte studies in terms of dosimetry. Use of such studies in the abdomen should be limited to early images, usually before 2 hours, to avoid confusion with the normal route of excretion in the bowel.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Brown ML,Hung JC,Vetter RJ,O'Connor MK,Chowdhury S,Forstrom LA

doi

10.1097/00004424-199404000-00010

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

443-7

issue

4

eissn

0020-9996

issn

1536-0210

journal_volume

29

pub_type

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