The blood-brain barrier: effects of nonionic contrast media with and without addition of Ca2+ and Mg2+.

Abstract:

:Trypan blue and 197HgCl2 were used as markers of the increased leakage through the blood-brain barrier which developed after selective injection of different contrast media formulations into the internal carotid arteries of rabbits. Interest was focused on a new, experimental, nonionic medium (C-29) and possible effects resulting from the addition of Ca2+ and Mg2+ to nonionic contrast media. Using 197Hg, it was possible to quantitate the increase in extravasation produced by the contrast media. C-29 caused less damage than either metrizamide or meglumine iothalamate. The addition of Ca2+ and Mg2+ to nonionic contrast media seemed to stabilize the blood-brain barrier.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Golman K

doi

10.1097/00004424-197907000-00007

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

305-8

issue

4

eissn

0020-9996

issn

1536-0210

journal_volume

14

pub_type

杂志文章
  • Dynamic contrast-enhanced ultrasound for assessment of skeletal muscle microcirculation in peripheral arterial disease.

    abstract:OBJECTIVE:: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able to detect alterations in the microvascular perfusion and arterial perfusion reserve in patients suffering from peripheral arterial disease (PAD) in comparison with hea...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182183a77

    authors: Amarteifio E,Weber MA,Wormsbecher S,Demirel S,Krakowski-Roosen H,Jöres A,Braun S,Delorme S,Böckler D,Kauczor HU,Krix M

    更新日期:2011-08-01 00:00:00

  • Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults.

    abstract:OBJECTIVES:The purposes of this study were to evaluate the reference range of quantitative computed tomography (QCT) measures of lung attenuation and airway parameter measurements in healthy nonsmoking adults and to identify sources of variation in those measures and possible means to adjust for them. MATERIALS AND ME...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318262292e

    authors: Zach JA,Newell JD Jr,Schroeder J,Murphy JR,Curran-Everett D,Hoffman EA,Westgate PM,Han MK,Silverman EK,Crapo JD,Lynch DA,COPDGene Investigators.

    更新日期:2012-10-01 00:00:00

  • Role of iodinated contrast material in the evaluation of myocardial infarction by computerized transmission tomography.

    abstract::In vivo and in vitro studies have shown that areas of myocardial infarctions can be delineated on CT scans after intravenous administration of iodinated contrast material to dogs with experimental myocardial infarctions. Within the first minute after intravenous administration of contrast material (initial myocardial ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198011001-00039

    authors: Higgins CB,Siemers PT,Newell JD,Schmidt W

    更新日期:1980-11-01 00:00:00

  • A direct comparison of noninvasive coronary angiography by electron beam tomography and navigator-echo-based magnetic resonance imaging for the detection of restenosis following coronary angioplasty.

    abstract:RATIONALE AND OBJECTIVES:To compare electron beam tomography (EBT) with MR imaging (MRI) for detection of restenosis after coronary angioplasty (PTCA). METHODS:One hundred eighteen patients after PTCA were investigated. By EBT, 50 axial images were acquired (3-mm slice thickness, 120-160 mL radiographic contrast agent...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200207000-00005

    authors: Ropers D,Regenfus M,Stilianakis N,Birke S,Kessler W,Moshage W,Laub G,Daniel WG,Achenbach S

    更新日期:2002-07-01 00:00:00

  • Tamm-Horsfall glycoprotein excretion and aggregation during intravenous urography. Relevance to acute renal failure.

    abstract::The effect of intravenous urography (IVU) on the excretion rate and precipitation of Tamm-Horsfall glycoprotein (THG) has been evaluated in 19 patients. Urine samples were collected immediately before the administration of contrast medium (U1) and then during the period of the excretion urogram (U2). The urinary THG: ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198501000-00014

    authors: Dawnay AB,Thornley C,Nockler I,Webb JA,Cattell WR

    更新日期:1985-01-01 00:00:00

  • Noninvasive measurement of an index of renal blood flow.

    abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198307000-00009

    authors: Powers TA,Rees RS,Bowen RD

    更新日期:1983-07-01 00:00:00

  • Pharmacokinetics and safety of iomeprol in healthy volunteers and in patients with renal impairment or end-stage renal disease requiring hemodialysis.

    abstract:RATIONALE AND OBJECTIVES:To present the results of two studies conducted to evaluate the pharmacokinetics and safety of iomeprol in healthy volunteers and in patients with various degrees of renal impairment. METHODS:In these two open-label, single-dose, phase I studies, a 50-mL dose of iomeprol 400 was administered i...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-200106000-00002

    authors: Lorusso V,Taroni P,Alvino S,Spinazzi A

    更新日期:2001-06-01 00:00:00

  • Opacification phase effects of angiographic contrast medium on left ventricular size and function: influence of initial ventricular volume and the pericardium.

    abstract::Prior studies of the opacification-phase effects of left ventricular (LV) injection of angiographic contrast medium (CM) on LV size and function have yielded discrepant results. A sensitive ultrasonic technique was used to measure LV dimension (Di) in 10 open-chest dogs with physiologic heart rates, and injection of s...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198209000-00009

    authors: LeWinter MM,Pavelec RS

    更新日期:1982-09-01 00:00:00

  • Consistency of rotator-cuff calcifications. Observations on plain radiography, sonography, computed tomography, and at needle treatment.

    abstract:RATIONALE AND OBJECTIVES:The author analyzes findings of consistency of rotator-cuff calcifications found at ultrasound (US)-guided needle treatment compared with findings of plain radiography, US, and computed tomography (CT). METHODS:Twenty patients had rotator-cuff calcifications (mean diameter, 1.5 cm; range, 1.1-...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199605000-00010

    authors: Farin PU

    更新日期:1996-05-01 00:00:00

  • Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract.

    abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-197811000-00008

    authors: Johansen JG

    更新日期:1978-11-01 00:00:00

  • Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver.

    abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31805f2682

    authors: Watanabe R,Matsumura M,Munemasa T,Fujimaki M,Suematsu M

    更新日期:2007-09-01 00:00:00

  • Computed tomography-pathologic assessment of laser-induced necrosis in rat liver.

    abstract:RATIONALE AND OBJECTIVES:Interstitial laser photocoagulation (ILP) causes localized tissue necrosis. This study was performed to determine 1) whether the changes seen on computed tomography (CT) correspond to the necrosis pathologically, and 2) which CT technique best shows the necrosis. METHODS:Eighteen Wistar rats h...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199312000-00014

    authors: Amin Z,Thurrell W,Spencer GM,Harries SA,Grant WE,Bown SG,Lees WR

    更新日期:1993-12-01 00:00:00

  • Diagnostic performance of dark-blood T2-weighted CMR for evaluation of acute myocardial injury.

    abstract:OBJECTIVES:We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182718672

    authors: Srichai MB,Lim RP,Lath N,Babb J,Axel L,Kim D

    更新日期:2013-01-01 00:00:00

  • Experimental preparations and models for MRS.

    abstract::Magnetic resonance spectroscopy (MRS) has been most extensively applied to the study of animal models and not humans. The major reason for this extensive animal research is due to the nature of the early magnetic resonance high-field magnets, which only permitted the study of isolated cells, tissues, or small animals....

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-198912000-00004

    authors: Balaban RS

    更新日期:1989-12-01 00:00:00

  • Computer-aided detection for computed tomographic colonography screening: a prospective comparison of a double-reading paradigm with first-reader computer-aided detection against second-reader computer-aided detection.

    abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000009

    authors: Iussich G,Correale L,Senore C,Hassan C,Segnan N,Campanella D,Bert A,Galatola G,Laudi C,Regge D

    更新日期:2014-03-01 00:00:00

  • Detection of breast abnormalities on teleradiology transmitted mammograms.

    abstract::The authors conducted an observer performance study to compare breast lesion detection of conventional mammography (CM) with teleradiology (TE) transmitted mammograms. One hundred four abnormal, single-projection mammographic images were transmitted by teleradiology. Abnormalities included 11 cases with skin thickenin...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199010000-00007

    authors: Fajardo LL,Yoshino MT,Seeley GW,Hunt R,Hunter TB,Friedman R,Cardenas D,Boyle R

    更新日期:1990-10-01 00:00:00

  • Digital mammography using iodine-based contrast media: initial clinical experience with dynamic contrast medium enhancement.

    abstract:PURPOSE:We sought to evaluate the potential of dynamic contrast enhancement after the intravenous administration of an iodine-based contrast medium in full-field digital mammography. MATERIAL AND METHODS:A protocol for image acquisition was established for contrast-enhanced mammography and the mammography unit (Senogr...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000167421.83203.4e

    authors: Diekmann F,Diekmann S,Jeunehomme F,Muller S,Hamm B,Bick U

    更新日期:2005-07-01 00:00:00

  • Multiphase magnetic resonance angiography of the abdominal and pelvic arteries: results of a bicenter multireader analysis.

    abstract:RATIONALE AND OBJECTIVES:The objective is to assess the diagnostic accuracy and interobserver variability of multiphase 3D gadolinium-enhanced magnetic resonance angiography (3D-Gd-MRA) for assessment of abdominal and pelvic vascular disease. METHODS:In 41 patients from two different institutions multiphase 3D-Gd-MRA ...

    journal_title:Investigative radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004424-200201000-00005

    authors: Schoenberg SO,Essig M,Hallscheidt P,Sharafuddin MJ,Stolpen AH,Knopp MV,Yuh WT

    更新日期:2002-01-01 00:00:00

  • The influence of contrast medium dose on filtration fraction in the rabbit kidney.

    abstract::We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the trace...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198309000-00007

    authors: Harvey LA,Caldicott WJ

    更新日期:1983-09-01 00:00:00

  • AcidoCEST-UTE MRI for the Assessment of Extracellular pH of Joint Tissues at 3 T.

    abstract:OBJECTIVES:The goal of this study was to demonstrate feasibility of measuring extracellular pH in cartilage and meniscus using acidoCEST technique with a 3-dimensional ultrashort echo time readout (acidoCEST-UTE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Magnetization transfer ratio asymmetry, radiofrequ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000576

    authors: Ma YJ,High RA,Tang Q,Wan L,Jerban S,Du J,Chang EY

    更新日期:2019-09-01 00:00:00

  • Evaluation and validation of ureteric jet index by glomerular filtration rate.

    abstract:RATIONALE AND OBJECTIVES:Ureteric jet index (UJI), a newly developed technique derived from color Doppler ultrasonography, may hold promise in evaluating renal function because of its ability to evaluate individual renal function and the use of nonionizing radiation. To assess the usefulness of UJI, the authors in this...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199908000-00001

    authors: Chiu NT,Wu CC,Yao WJ,Tu DG,Lee BF,Tong YC,Pan CC

    更新日期:1999-08-01 00:00:00

  • Effects of dilating the canine pulmonary annulus with two balloons. Doppler ultrasound and postmortem findings.

    abstract::Simultaneous inflation of two balloons may be necessary for balloon dilation valvuloplasty in patients with a large annulus. We examined the cardiovascular effects of dilating the pulmonary annulus with two balloons in 18 normal dogs using pulsed Doppler ultrasound and gross and microscopic examination. When the ratio...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198808000-00005

    authors: Butto F,Burke B,Berry JM,Amplatz K,Bass JL

    更新日期:1988-08-01 00:00:00

  • The pediatric tracheostomy: III). An appraisal of xerography.

    abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197807000-00002

    authors: Scott JR,Kramer SS,Griscom NT

    更新日期:1978-07-01 00:00:00

  • Ultrasonic detection of osteomyelitis. Pathologic correlation in an animal model.

    abstract::The authors correlated sonographic findings with histologic findings in a rabbit model of osteomyelitis. Staphylococcus aureus osteomyelitis was induced in the femora of 11 New Zealand white rabbits. The opposite leg was used as a control. Sonographic findings showed fluid adjacent to the bone in 11 cases. The fluid w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199202000-00002

    authors: Abiri MM,DeAngelis GA,Kirpekar M,Abou AN,Ablow RC

    更新日期:1992-02-01 00:00:00

  • Design of an isolated pig heart preparation for positron emission tomography and magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:Validation of new positron emission tomography (PET) tracers or magnetic (MR) imaging contrast agents is based on isolated rodent heart preparations. The use of larger animals could provide a more direct validation using the devices used for humans. METHODS:An isolated pig heart preparation ha...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199711000-00010

    authors: Casali C,Obadia JF,Canet E,Bendjelid K,André-Fouët X,Revel D,Janier MF

    更新日期:1997-11-01 00:00:00

  • Microcomputer-based technique for 3-D reconstruction and volume measurement of computer tomographic images. Part 1: Phantom studies.

    abstract::This paper presents a microcomputer-based technique that accurately quantifies volumes from computed tomographic (CT) scans of irregularly shaped objects as well as displaying 3-D reconstructions. The method uses standard CT film, allowing analysis of previous or outside CT studies. The planimetry method showed less t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198812000-00001

    authors: Albright RE Jr,Fram EK

    更新日期:1988-12-01 00:00:00

  • Effect of intraarticular pressure on patellar position. Computed tomography study in cadaveric specimens.

    abstract:RATIONALE AND OBJECTIVES:The purpose of the study was to evaluate the effect of articular fluid distention on patellar position at different degrees of knee angulation. METHODS:Patellar position in 10 cadaveric knee specimens was determined with 30, 100, and 200 mm Hg joint distention at 45, 20, and 5 degrees of knee ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199602000-00001

    authors: Brossmann J,Koch S,Schwarzenberg H,Link J,Muhle C,Bull CC,Heller M

    更新日期:1996-02-01 00:00:00

  • Temperature-Sensitive Frozen-Tissue Imaging for Cryoablation Monitoring Using STIR-UTE MRI.

    abstract:PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000642

    authors: Tokuda J,Wang Q,Tuncali K,Seethamraju RT,Tempany CM,Schmidt EJ

    更新日期:2020-05-01 00:00:00

  • The clotting issue: etiologic factors in thromboembolism. II. Clinical considerations.

    abstract:RATIONALE AND OBJECTIVES:The authors analyze the origins of the "clotting issue," the controversy that began in the 1980s when contrast media, once perceived as good flushing agents for catheters because of their assumed anticoagulant properties, came under attack for allegedly causing thromboembolism. Laboratory studi...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:

    authors: Dawson P,Cousins C,Bradshaw A

    更新日期:1993-11-01 00:00:00

  • Characterization of radial forces in Z stents.

    abstract:RATIONAL AND OBJECTIVES:The purpose of this study was to evaluate the effects of variation in design parameters on the resultant radial force. We evaluated the influence of wire gauge, leg length, and number of bends on the radial force produced by z stents and compared these with radial forces produced by commercial s...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200109000-00004

    authors: Snowhill PB,Nosher JL,Siegel RL,Silver FH

    更新日期:2001-09-01 00:00:00