Design of an isolated pig heart preparation for positron emission tomography and magnetic resonance imaging.

Abstract:

RATIONALE AND OBJECTIVES:Validation of new positron emission tomography (PET) tracers or magnetic (MR) imaging contrast agents is based on isolated rodent heart preparations. The use of larger animals could provide a more direct validation using the devices used for humans. METHODS:An isolated pig heart preparation has been developed and adapted to the technical constraints of whole body PET and MR imaging. This preparation could be used either in the Langendorff or working mode after selective cannulation of both coronary arteries. RESULTS:The authors showed that quantification of regional kinetics of PET tracers was possible using this preparation by measuring fluorine-18-labeled deoxyglycose (18FDG) kinetics in remote and ischemic territories. Experiments using MR imaging contrast agents, for myocardial perfusion, demonstrated the ability of this preparation to accurately validate these contrast agents over a wide range of flow rates. CONCLUSIONS:An isolated pig heart preparation could be developed to fulfill the constraints of PET and MR imaging, and proved useful for the study of the distribution of different tracers or contrast media developed for functional cardiac imaging in humans.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Casali C,Obadia JF,Canet E,Bendjelid K,André-Fouët X,Revel D,Janier MF

doi

10.1097/00004424-199711000-00010

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

713-20

issue

11

eissn

0020-9996

issn

1536-0210

journal_volume

32

pub_type

杂志文章
  • Binary nature and radiographic identifiability of craniosynostosis.

    abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199410000-00005

    authors: Pilgram TK,Vannier MW,Marsh JL,Kraemer BB,Rayne SC,Gado MH,Moran CJ,McAlister WH,Shackelford GD,Hardesty RA

    更新日期:1994-10-01 00:00:00

  • Effect of lumbar puncture on flow of cerebrospinal fluid.

    abstract::The rate at which isotopes descend from the cisterna magna to the lumbar subarachnoid space is highly variable. In monkeys, with and without previous lumbar puncture, transit time was measured. In animals with a previous lumbar puncture, transit times were 10 to 120 minutes; in monkeys without a previous lumbar punctu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198805000-00005

    authors: Lipman B,Palmer D,Noble J,Haughton V,Collier D

    更新日期:1988-05-01 00:00:00

  • Pathophysiology of radiocontrast nephropathy: a role for medullary hypoxia.

    abstract::Recent experimental data underlies the role of hypoxic tubular injury in the pathophysiology of radiocontrast nephropathy. Although systemic transient hypoxemia, increased blood viscosity, and a leftward shift of the oxygen-hemoglobin dissociation curve may all contribute to intrarenal hypoxia, imbalance between oxyge...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199911000-00004

    authors: Heyman SN,Reichman J,Brezis M

    更新日期:1999-11-01 00:00:00

  • Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.

    abstract:OBJECTIVES:To evaluate the potential of quantitative assays of vascular characteristics based on dynamic contrast-enhanced magnetic resonance imaging (MRI) using a macromolecular contrast medium (MMCM) to search for and measure effects of dimethyl sulfoxide (DMSO) on cancer vasculature with microscopic correlations. M...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318164b71d

    authors: Cyran CC,Sennino B,Chaopathomkul B,Fu Y,Rogut V,Shames DM,Wendland MF,McDonald DM,Brasch RC

    更新日期:2008-05-01 00:00:00

  • High resolution sonography of the menisci of the knee.

    abstract::High-resolution real-time ultrasonography (5, 7.5, and 10 MHz) was used to examine the menisci of the knee in ten normal volunteers and in ten patients with knee injuries. The posterior horns of the medial and lateral menisci were easily demonstrated. Normal anatomy and pathologic changes could be imaged in the menisc...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198604000-00008

    authors: Selby B,Richardson ML,Montana MA,Teitz CC,Larson RV,Mack LA

    更新日期:1986-04-01 00:00:00

  • Choice of contrast material for four-hour delayed contrast-enhanced computed tomography of the liver.

    abstract::Four-hour delayed contrast-enhanced computed tomography (DCECT) shows promise for improved detection of focal liver lesions. No previous studies have examined the use of nonionic contrast materials for DCECT. The authors undertook a case-controlled study in monkeys to define the relative efficacies of iopamidol and di...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198910000-00010

    authors: Feuerstein IM,Girton ME

    更新日期:1989-10-01 00:00:00

  • Increased ablation zones using a cryo-based internally cooled bipolar RF applicator in ex vivo bovine liver.

    abstract:PURPOSE:To evaluate the feasibility of ex vivo ablation implementing a cryo-based internally cooled bipolar radiofrequency (RF) applicator and to determine the influence of power and gas pressure on the size and shape of the resulting ablation zones. MATERIALS AND METHODS:Two hundred twenty-five ablations were perform...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181b66d11

    authors: Rempp H,Voigtländer M,Clasen S,Kempf S,Neugebauer A,Schraml C,Schmidt D,Claussen CD,Enderle MD,Goldberg SN,Pereira PL

    更新日期:2009-12-01 00:00:00

  • Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

    abstract:RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200211000-00001

    authors: Schumann PA,Christiansen JP,Quigley RM,McCreery TP,Sweitzer RH,Unger EC,Lindner JR,Matsunaga TO

    更新日期:2002-11-01 00:00:00

  • Can Ferumoxytol be Used as a Contrast Agent to Differentiate Between Acute and Chronic Inflammatory Kidney Disease?: Feasibility Study in a Rat Model.

    abstract:OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000209

    authors: Budjan J,Neudecker S,Schock-Kusch D,Kraenzlin B,Schoenberg SO,Michaely HJ,Attenberger UI

    更新日期:2016-02-01 00:00:00

  • Specific absorption rate as a poor indicator of magnetic resonance-related implant heating.

    abstract::Recent publications of the magnetic resonance safety profile of neurostimulators, cardiac pacemakers, and other implanted devices imply that these devices are no longer a contraindication for magnetic resonance imaging. It is very promising that patients who have these implanted devices may in the future no longer be ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000185898.59140.91

    authors: Nitz WR,Brinker G,Diehl D,Frese G

    更新日期:2005-12-01 00:00:00

  • Long-term effect of irradiation on lymph node uptake of interstitially delivered nanoparticulate contrast media.

    abstract:RATIONALE AND OBJECTIVES:To characterize the long-term effects of therapeutic doses of ionizing radiation on the uptake and distribution of percutaneously delivered particulate contrast media in normal lymph nodes. METHODS:Two milliliters of an iodinated nanoparticle suspension (76 mg I/mL) was injected subcutaneously...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200003000-00007

    authors: Wisner ER,Théon A,Griffey SM,McIntire GL

    更新日期:2000-03-01 00:00:00

  • Hemodynamic effect of iodinated high-viscosity contrast medium in the rat kidney: a diffusion-weighted MRI feasibility study.

    abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200011000-00001

    authors: Laissy JP,Menegazzo D,Dumont E,Piekarski JD,Karila-Cohen P,Chillon S,Schouman-Claeys E

    更新日期:2000-11-01 00:00:00

  • Developments in X-Ray Contrast Media and the Potential Impact on Computed Tomography.

    abstract::Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of ap...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000696

    authors: Schöckel L,Jost G,Seidensticker P,Lengsfeld P,Palkowitsch P,Pietsch H

    更新日期:2020-09-01 00:00:00

  • Sensitivity to detect small coronary artery calcium lesions with varying slice thickness using electron beam tomography.

    abstract:RATIONALE AND OBJECTIVE:To estimate the sensitivity to find small coronary artery calcium lesions with use of different slice widths with electron beam tomography. MATERIALS AND METHODS:Two studies were performed. Study 1 utilized double scanning of a stationary cork phantom with three different slice thickness (1.5, ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.RLI.0000055289.97726.B1

    authors: Mao S,Child J,Carson S,Liu SC,Oudiz RJ,Budoff MJ

    更新日期:2003-03-01 00:00:00

  • Short-term effects of a new intravascular nitinol stent in canine arteries.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the short-term effects of a new nitinol stent on canine arteries. METHODS:Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199905000-00007

    authors: Lee KW,Park JH,Chung JW,Kim WS,Lee W,Yeon KM

    更新日期:1999-05-01 00:00:00

  • Fluorescent bacterial magnetic nanoparticles as bimodal contrast agents.

    abstract:OBJECTIVES:The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS:Bacterial magnetic nanopa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000255832.44443.e7

    authors: Lisy MR,Hartung A,Lang C,Schüler D,Richter W,Reichenbach JR,Kaiser WA,Hilger I

    更新日期:2007-04-01 00:00:00

  • Evaluation of perfluoroctylbromide for lymphography in the dog: comparison with ethiodol.

    abstract::The efficacy and safety of perfluoroctylbromide as a diagnostic contrast agent for direct lymphography was studied in mongrel dogs. This radiopaque perfluorocarbon has several advantages over Ethiodol. The liquid compound has injection times one-fifth of that required for Ethiodol. When dosages were three to four tim...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197707000-00012

    authors: Liebner EJ

    更新日期:1977-07-01 00:00:00

  • Observation on the metabolism of iopanoyl (Telepaque) glucuronide in dogs treated with antibiotics.

    abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197805000-00011

    authors: Thoeni RF,Goldberg HI,Moss AA,Lin SK,Brito AC

    更新日期:1978-05-01 00:00:00

  • Helium3 polarization using spin exchange technique: application to simultaneous pulmonary ventilation/perfusion imaging in small animals.

    abstract:RATIONALE AND OBJECTIVES:To develop a simple and robust helium3 polarization system dedicated to small animal imaging. To demonstrate the potential of helium3 imaging for pulmonary ventilation and perfusion studies. METHODS:A home-built polarization system based on spin-exchange technique was used. This system was app...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Stupar V,Berthezène Y,Canet E,Tournier H,Dupuich D,Crémillieux Y

    更新日期:2003-06-01 00:00:00

  • Depiction of reperfused myocardial infarction using contrast-enhanced spin echo and gradient echo magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:The authors used gadolinium (Gd) chelate as a T1, T2, and T2* enhancing agent in reperfused myocardial infarction to compare the appearance of reperfused myocardial infarction on spin echo and gradient echo magnetic resonance (MR) sequences. METHODS:Rats (n = 28) were subjected to reperfused m...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199807000-00002

    authors: Geschwind JF,Saeed M,Wendland MF,Higgins CB

    更新日期:1998-07-01 00:00:00

  • The use of a thrombus-specific ultrasound contrast agent to detect thrombus in arteriovenous fistulae.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the use of a new thrombus-specific ultrasound contrast agent, MRX-408, in the ultrasonic detection of thrombus in arteriovenous (AV) fistulae. METHODS:Six purpose-bred mongrels with two AV fistulae each were imaged with gray-scale ultrasound 7 weeks after graft implantation before ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200001000-00010

    authors: Unger E,Metzger P 3rd,Krupinski E,Baker M,Hulett R,Gabaeff D,Mills J,Ihnat D,McCreery T

    更新日期:2000-01-01 00:00:00

  • Ioversol clinical safety summary.

    abstract::The authors evaluated double-blind comparative and open-label clinical trials in 1,186 patients who received ioversol to evaluate the safety and efficacy of ioversol, a new nonionic low-osmolality contrast medium, at iodine concentrations of 32%, 24%, and 16%. The results indicate that ioversol was well tolerated in a...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004424-198906001-00020

    authors: Benamor M,Aten EM,McElvany KD,Lankin DG,James MA,Buy-Gandal T,Harashe LT,Weinandt WJ

    更新日期:1989-06-01 00:00:00

  • Photon-Counting Computed Tomography for Vascular Imaging of the Head and Neck: First In Vivo Human Results.

    abstract:PURPOSE:The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS:In this institutional r...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000418

    authors: Symons R,Reich DS,Bagheri M,Cork TE,Krauss B,Ulzheimer S,Kappler S,Bluemke DA,Pourmorteza A

    更新日期:2018-03-01 00:00:00

  • Phlebography. Survey and present state.

    abstract::Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of new nonionic contrast media is presented. ...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Enge I

    更新日期:1985-01-01 00:00:00

  • Breast stereotactic core biopsy washings: abundant cell samples from clinically occult lesions for flow cytometric DNA analysis.

    abstract:RATIONALE AND OBJECTIVES:The object of this study was to determine by flow cytometry the cellular and DNA content of the washings of core biopsy samples and needles obtained during stereotactic core biopsies of clinically occult suspicious lesions. METHODS:Fourteen-gauge core multipass biopsy inner-needle saline washi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199801000-00008

    authors: Stomper PC,Budnick RM,Stewart CC

    更新日期:1998-01-01 00:00:00

  • Constructing pre- and post-tests in a medical student elective.

    abstract::The importance of evaluating medical student performance has been widely addressed in the medical education literature. Multiple-choice examinations are the preferred method of testing because they are easy to administer and score. Development of parallel or equivalent pre- and post-examinations provides objective inf...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Blane CE,Calhoun JG,Vydareny KH

    更新日期:1986-09-01 00:00:00

  • Renal effects of bicarbonate versus saline infusion for iso- and lowosmolar contrast media in rats.

    abstract:OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31822311a9

    authors: Ladwig M,Flemming B,Seeliger E,Sargsyan L,Persson PB

    更新日期:2011-11-01 00:00:00

  • Systemic absorption of gallbladder sclerosing agents in the rabbit. A preliminary study.

    abstract::The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 mg/dl and of tetracycline was 4.6 micrograms/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198605000-00005

    authors: Remley KB,Cubberley DA,Watanabe AS,Nelson JA,Colby TV

    更新日期:1986-05-01 00:00:00

  • Experimental carotid aneurysms: I. Simple surgical production and radiographic evaluation.

    abstract::Using simple surgical techniques, experimental carotid aneurysms are created which simulate some types of human berry aneurysms, both in hemodynamic and radiographic behavior. End to side anastomoses of an external jugular vein graft to the common carotid artery can be carried out by radiologic personnel with no forma...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197703000-00009

    authors: Kerber CW,Buschman RW

    更新日期:1977-03-01 00:00:00

  • Protective effects of corticosteroids in contrast material anaphylaxis.

    abstract::A prospective, randomized study of the potential protective effects of corticosteroids administered as pretreatment against contrast material (CM) reactions is reported. Patients (n = 6,763) from multiple institutions received either a single dose of steroids (32 mg of oral methylprednisolone, approximately 2 hours be...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00004424-198809001-00035

    authors: Lasser EC,Berry CC,Talner LB,Santini LC,Lang EK,Gerber FH,Stolberg HO

    更新日期:1988-09-01 00:00:00