Abstract:
OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others found either no effect or an enhanced incidence of CM-induced AKI after giving NaHCO₃. Because of their different tubular resorption, NaHCO₃ and saline may have a different capacity to flush the nephron. In this study, we compare the magnitudes by which NaHCO₃ and saline can enhance urinary flow, prevent a decline in glomerular filtration rate (GFR), and limit an increase in urine viscosity, as caused by CM administration. MATERIALS AND METHODS:Prewarmed (37°C) CM were administered as 1.5 mL bolus into the thoracic aorta of anesthetized rats. Following 2 CM were studied: iso-osmolar iodixanol (320 mg I/mL) and low-osmolar iopromide (370 mg I/mL). Four protocols (n = 7 rats per protocol) were followed: (1) saline + iodixanol, (2) saline + iopromide, (3) NaHCO₃ + iodixanol, and (4) NaHCO₃ + iopromide. Isotonic saline or NaHCO₃ were infused at a rate of 4 mL/h per kg BM, initiated 60 minutes before CM administration and continued throughout the observation period of 100 minutes. Urine volume was measured gravimetrically, urine viscosity was measured by a microviscometer, and GFR was determined by creatinine clearance. RESULTS:As compared with saline infusions, NaHCO₃ infusions did not significantly alter the effects that iodixanol and iopromide exerted on urine flow rate, urine viscosity, and GFR. In the iopromide protocols, CM-induced increase in urine flow was about 50% greater than in the respective iodixanol protocols. Conversely, in the iodixanol protocols, urine viscosity was up to 10-fold greater than in the respective iopromide protocol. In the iodixanol protocols, GFR decreased transiently (10-30 min post-CM) by up to 50%, whereas GFR did not decrease in the iopromide protocols. CONCLUSION:Infusing either saline or NaHCO₃ seems to make little difference with regard to urine flow, urine viscosity, and GFR. However, the CM used has a significant effect on these measures. Iopromide enhances urine flow by a greater magnitude than iodixanol, whereas the latter increases urine viscosity to a larger degree than iopromide and transiently decreases GFR.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Ladwig M,Flemming B,Seeliger E,Sargsyan L,Persson PBdoi
10.1097/RLI.0b013e31822311a9subject
Has Abstractpub_date
2011-11-01 00:00:00pages
672-7issue
11eissn
0020-9996issn
1536-0210journal_volume
46pub_type
杂志文章abstract::In this article, we propose a semiautomatic method for time-continuous contour detection in all phases of the cardiac cycle in magnetic resonance sequences. The method is based on multidimensional dynamic programming. After shape parameterization, cost hypercubes are filled with image-feature derived cost function val...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000194070.88432.24
更新日期:2006-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To summarize the chemical synthesis, physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P743, a new macromolecular iodinated contrast medium. METHODS:The synthesis and molecular modeling of the iodinated macromolecule P743 are described. The pharmacokineti...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200101000-00006
更新日期:2001-01-01 00:00:00
abstract::At a given radiation dosage and field of view, five variables are under meaningful control for intravenous digital subtraction angiography (IV-DSA): concentration and quantity of contrast media injected, volume of injectate, rate of injection, and site of injection. Some controversy exists regarding the selection of a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198401000-00007
更新日期:1984-01-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
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abstract:RATIONALE AND OBJECTIVE:The authors performed a retrospective study in ultrasound to investigate new aspects in the sonomorphology of lymph node metastases of the neck. In this study, it could be demonstrated the first time that the histologic characteristics of the metastases determine the sonographic appearance. In a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199609000-00001
更新日期:1996-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:It is widely believed that down-sizing catheters, and possibly needles, will decrease damage to the entry vessel in the performance of angiography. The purposes of this in vitro experiment are to determine if smaller needles produce less arterial wall damage than larger needles and to assess th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00001
更新日期:1992-10-01 00:00:00
abstract::Renal arteriography gives a reliable anatomic delineation of the renal vasculature. However, the presence of renal arterial disease does not determine the physiologic significance of the lesion. The intravenous infusion of saralasin, a specific angiotensin II antagonist, has been investigated as a method for identify...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197711000-00006
更新日期:1977-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The influence of lipiodol injection on hepatic morphology and function was investigated in 119 rabbits with hepatic VX2 tumors. METHODS:The rabbits were divided into the following three groups, according to the materials injected via the proper hepatic artery: group 1 received doxorubicin (Adr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199302000-00009
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...
journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Investigative radiology
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abstract:RATIONALE AND OBJECTIVES:The aim of the study was to examine the effects of azelastine on proliferation, clonogenic activity, cell-cycle, and migration of human aortic smooth-muscle cells (haSMCs) in vitro. METHODS:HaSMCs were treated for 4 days with azelastine (1 micromol/L, 25 micromol/L, 50 micromol/L). Half of the...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200205000-00002
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol c...
journal_title:Investigative radiology
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doi:10.1097/01.rli.0000183054.43131.a8
更新日期:2005-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:As an imaging modality for follow-up during continuous or repeated hepatic arterial infusion chemotherapy using a hepatic intra-arterial indwelling catheter, the usefulness of CT while infusing contrast through the indwelling catheter (reservoir port) was examined. METHODS:Using reservoir ports implanted in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199912000-00003
更新日期:1999-12-01 00:00:00
abstract::The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 mg/dl and of tetracycline was 4.6 micrograms/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198605000-00005
更新日期:1986-05-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:
更新日期:1993-05-01 00:00:00
abstract::The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop a method to determine hepatic and renal clearance of the 2 diastereoisomers (Gd-A, Gd-B) of Gd-EOB-DTPA separately. MATERIALS AND METHODS:Between July 2017 and February 2018, 41 patients with hepatic disease were prospectively included. For each patient, 1 mL of iopromid...
journal_title:Investigative radiology
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更新日期:2020-03-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197707000-00012
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journal_title:Investigative radiology
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doi:10.1097/RLI.0000000000000026
更新日期:2014-05-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199610000-00003
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:Intra-arterial digital subtraction angiography (IA-DSA), an invasive procedure, is the current reference examination after percutaneous transluminal angioplasty and stenting for the detection of in-stent restenosis (ISR). In this phantom study, we evaluated flat-panel angiographic computed tomography after i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318276db43
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:Imaging of the kidney using blood oxygen level dependent MR presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. We sought to define the differences between regions within kidneys and to optimize selection of regions of interest ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c1e8
更新日期:2009-09-01 00:00:00
abstract::A radiographic method for use in the closed-chest dog is described which allows the quantitation of segmental mechanical performance. Previous work has shown that the area of the pressure-length loop (an approximation of a stress-strain integral) is a useful measure of the mechanical work performed by a segment of myo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197611000-00010
更新日期:1976-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199704000-00008
更新日期:1997-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study evaluating a cesium iodide-amorphous silicon-based flat-panel detector was to optimize the x-ray spectrum for chest radiography combining excellent contrast-detail visibility with reduced patient exposure. MATERIALS AND METHODS:A Lucite plate with 36 drilled holes of ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000138091.96320.f8
更新日期:2004-10-01 00:00:00
abstract::French physicians must obtain their patient's consent before carrying out an action that interferes with the patient's corporal integrity. The doctor must use simple, approximate, intelligent, and honest words that help the patient to reach the indispensable decision. Proof of lack of consent lies with the patient. Th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00006
更新日期:1988-09-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00