Assessment of large bowel motility by cine magnetic resonance imaging using two different prokinetic agents: a feasibility study.

Abstract:

OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol consisted of 2 sets of repeated measurements using coronal T2-weighted HASTE sequences, adjusted to the course of the colon. For the assessment of large bowel motility, the changes of the luminal diameter were measured at 5 defined locations in the ascending, transverse, and descending colon. RESULTS:In all examined volunteers after senna tea, the mean number of significant changes in the ascending colon was 8.6 and after erythromycin, 7.2. In the transverse colon, 9.6 diameters changed significantly for senna tea and 7.2 for erythromycin. In the descending colon, 6.6 diameters changed after senna tea and 7.2 after erythromycin. CONCLUSION:Senna tea and erythromycin proved to induce large bowel motility; senna tea was more effective. Functional cine MRI is a reliable, noninvasive method for the assessment of colonic motility.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Buhmann S,Kirchhoff C,Wielage C,Mussack T,Reiser MF,Lienemann A

doi

10.1097/01.rli.0000183054.43131.a8

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

689-94

issue

11

eissn

0020-9996

issn

1536-0210

pii

00004424-200511000-00001

journal_volume

40

pub_type

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