Abstract:
PURPOSE:The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear and macrocyclic GBCAs. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board and the requirement for informed consent was waived. We identified 92 children who underwent at least 4 consecutive MR examinations exclusively using either linear GBCA (gadodiamide or gadopentetate dimeglumine, n = 41) or macrocyclic GBCA (gadoterate meglumine, n = 51). Signal intensity ratio changes in the DN to pons and GP to thalamus between the first and last MR examinations were calculated. RESULTS:The SI ratios in the linear group increased significantly between the first and last MR examinations (mean difference: DN to pons, 0.0461 ± 0.0480, P < 0.001; GP to thalamus, 0.0332 ± 0.0385, P < 0.001), but not in the macrocyclic group (mean difference: DN to pons, -0.0010 ± 0.0371, P = 0.855; GP to thalamus, 0.0007 ± 0.0294, P = 0.867). In the linear regression analysis, the numbers of administrations of gadodiamide and gadopentetate dimeglumine were highly associated with the differences in SI ratios (DN to pons, P < 0.001 and P = 0.003; GP to thalamus, P < 0.001 and P = 0.002, respectively). CONCLUSION:The SIs of the DN and GP on unenhanced T1-weighted images increased after serial administrations of linear GBCA, but not macrocyclic GBCA, in children. The number of linear GBCA administration had a linear association with the SI changes in the DN and GP.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Ryu YJ,Choi YH,Cheon JE,Lee WJ,Park S,Park JE,Kim WS,Kim IOdoi
10.1097/RLI.0000000000000436subject
Has Abstractpub_date
2018-04-01 00:00:00pages
246-255issue
4eissn
0020-9996issn
1536-0210journal_volume
53pub_type
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journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
abstract:RATIONAL AND OBJECTIVES:The feasibility of tubal occlusion by selective salpingography was tested in an animal model; three novel occluding materials also were tested for this application. METHODS:Unilateral selective salpingography was performed in three groups of six rabbits; fallopian tubes were embolized with etha...
journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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doi:10.1097/00004424-197707000-00004
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journal_title:Investigative radiology
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更新日期:1999-05-01 00:00:00
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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更新日期:1982-07-01 00:00:00
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journal_title:Investigative radiology
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更新日期:2015-11-01 00:00:00
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-05-01 00:00:00
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更新日期:1994-04-01 00:00:00
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journal_title:Investigative radiology
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更新日期:1992-07-01 00:00:00
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-11-01 00:00:00
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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更新日期:1993-02-01 00:00:00
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journal_title:Investigative radiology
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