Pyrroxamide, a nonionic nitroxyl spin label contrast agent for magnetic resonance imaging. Mutagenesis and cell survival.

abstract：RATIONALE AND OBJECTIVES:Ultrasound can cause destruction of microbubble contrast agents used to enhance medical ultrasound imaging. This study sought to characterize the dynamics of this interaction by direct visual observation of microbubbles during insonification in vitro by a medical ultrasound imaging system. MET...

journal_title：Investigative radiology

authors： Klibanov AL,Ferrara KW,Hughes MS,Wible JH Jr,Wojdyla JK,Dayton PA,Morgan KE,Brandenburger GH

更新日期：1998-12-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors investigated whether gadolinium-ethoxybenzyl-DTPA (Gd-EOB-DTPA) can be eliminated in the absence of the two usual excretory pathways (urinary or biliary) and whether a remaining excretory pathway is able to compensate for impaired liver or kidney function. METHODS:The study was per...

journal_title：Investigative radiology

authors： Mühler A,Heinzelmann I,Weinmann HJ

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...

journal_title：Investigative radiology

authors： Baur AD,Maxeiner A,Franiel T,Kilic E,Huppertz A,Schwenke C,Hamm B,Durmus T

更新日期：2014-06-01 00:00:00

abstract：:Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of ap...

journal_title：Investigative radiology

authors： Schöckel L,Jost G,Seidensticker P,Lengsfeld P,Palkowitsch P,Pietsch H

更新日期：2020-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...

journal_title：Investigative radiology

authors： Kennedy AS,Archambeau JO,Archambeau MH,Holshouser B,Thompson J,Moyers M,Hinshaw D Jr,Slater JM

更新日期：1995-04-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions. MATERIALS AND METHODS:A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar s...

journal_title：Investigative radiology

authors： Puttagunta NR,Gibby WA,Puttagunta VL

更新日期：1996-10-01 00:00:00

abstract：:We evaluated the density distribution (anterior-posterior) of the right lung in 19 acutely anesthetized supine dogs using computed transmission tomography (CTT). Eleven dogs served as controls, and eight received 0.12 cc/kg of intravenously administered oleic acid. The latter were sequentially imaged over 1 hour. Nine...

journal_title：Investigative radiology

authors： Slutsky RA,Long S,Peck WW,Higgins CB,Mattrey R

更新日期：1984-05-01 00:00:00

abstract：:Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...

journal_title：Investigative radiology

authors： Kim SH,Park JH,Kim YI,Kim CW,Han MC

更新日期：1990-06-01 00:00:00

abstract：:The rates at which the paramagnetic compounds deoxyhemoglobin (Hb) and methemoglobin (MHb) form in vivo within an area of hemorrhage are unknown. The present experiment establishes the baseline concentrations and rates of change in paramagnetic hemoglobin concentrations, as well as the pH in normal heparinized and clo...

journal_title：Investigative radiology

authors： Taber KH,Migliore PJ,Pagani JJ,Ford JJ,McLauren T,Hayman LA

更新日期：1990-03-01 00:00:00

abstract：:Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...

journal_title：Investigative radiology

authors： Herzog RJ,Nelson JA,Staubus AE

更新日期：1976-01-01 00:00:00

abstract：:The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were ...

journal_title：Investigative radiology

authors： Lawson TL,Gomez JA,Margulis AR

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-...

journal_title：Investigative radiology

authors： Radbruch A,Weberling LD,Kieslich PJ,Hepp J,Kickingereder P,Wick W,Schlemmer HP,Bendszus M

更新日期：2015-12-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...

journal_title：Investigative radiology

authors： Berg A,Sailer J,Rand T,Moser E

更新日期：2003-07-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The basic characteristics of BR1, a novel echo contrast agent based on stabilized sulfur hexafluoride (SF6) microbubbles have been evaluated. METHODS:The authors determined the physicochemical properties (bubble concentration, bubble size distribution, resistance to pressure, and stability) an...

journal_title：Investigative radiology

authors： Schneider M,Arditi M,Barrau MB,Brochot J,Broillet A,Ventrone R,Yan F

更新日期：1995-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Diabetic patients frequently suffer contrast media-induced nephropathy. Hyperglycemia in diabetes mellitus causes gradual deterioration of glomerular mesangial cells (MCs) in the kidney. In this study, the authors investigated the response of rat MCs cultured in high-glucose medium to diatrizoa...

journal_title：Investigative radiology

authors： Wasaki M,Sugimoto J,Shirota K

更新日期：2001-07-01 00:00:00

abstract：:Three methods are presented which provide statistically acceptable estimates of mean transit time of opacified blood during angiography. While the methods vary in precision, the selection of the method appropriate for any particular experimental model depends on the degree of precision required to demonstrate the effe...

journal_title：Investigative radiology

authors： Silverman NR,Rosen L

更新日期：1977-07-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Studies describing the effects of radiographic contrast media (RCM) in leukocyte chemotaxis have been contradictory. No studies have been performed after in-vivo exposure. The authors assess the effect of RCM on leukocytes following in-vivo exposure. METHODS:Seventeen patients were studied aft...

journal_title：Investigative radiology

authors： Roobottom CA,Farrow R,Wells IP,Hurlock-Fimls N

更新日期：1994-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...

journal_title：Investigative radiology

authors： Putman CM,Chaloupka JC,Kailasnath P,Alderman J

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS:Bacterial magnetic nanopa...

journal_title：Investigative radiology

authors： Lisy MR,Hartung A,Lang C,Schüler D,Richter W,Reichenbach JR,Kaiser WA,Hilger I

更新日期：2007-04-01 00:00:00

abstract：:Sixteen observers averaging 7.4 years experience in interpreting radiology images and 16 observers without radiology training were tested for their ability to detect low-contrast signals in structured noise backgrounds using a digital display system. No significant difference in true positives, false positives, time t...

journal_title：Investigative radiology

authors： Rackow PL,Spitzer VM,Hendee WR

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:To prospectively determine the accuracy of 1.5 Tesla (T) and 3 T magnetic resonance angiography (MRA) versus digital subtraction angiography (DSA) in the depiction of infrageniculate arteries in patients with symptomatic peripheral arterial disease. PATIENTS AND METHODS:A prospective 1.5 T, 3 T MRA, and DSA co...

journal_title：Investigative radiology

authors： Diehm N,Kickuth R,Baumgartner I,Srivastav SK,Gretener S,Husmann MJ,Jaccard Y,Do do D,Triller J,Bonel HM

更新日期：2007-06-01 00:00:00

abstract：:Percutaneous injection of absolute ethanol into adenocarcinomas implanted in the hind leg of rats was evaluated as a potential cancer treatment. Intramuscular alcohol injections up to 10 mL/kg produced a local dose-dependent coagulation necrosis followed by granulation tissue formation and subsequent fibrosis but no a...

journal_title：Investigative radiology

authors： Burgener FA,Steinmetz SD

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the diagnostic value of x-ray dark-field imaging in projection radiography-based depiction of pneumothoraces in the neonatal murine lung, a potentially life-threatening medical condition that requires a timely and correct diagnosis. MATERIALS AND METHODS:By the use of a ...

journal_title：Investigative radiology

authors： Hellbach K,Yaroshenko A,Willer K,Pritzke T,Baumann A,Hesse N,Auweter S,Reiser MF,Eickelberg O,Pfeiffer F,Hilgendorff A,Meinel FG

更新日期：2016-10-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To establish a pig model suitable for imitating pulmonary emboli to facilitate research in the diagnosis of pulmonary embolism. METHODS:Thirteen animals were anesthetized, mechanically ventilated, and subjected to pulmonary artery catheterization initiated from the right external jugular vein....

journal_title：Investigative radiology

authors： Amundsen T,Kvaerness J,Aadahl P,Waage A,Bjermer L,Odegård A,Haraldseth O

更新日期：2000-05-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors developed a two-dimensional breathhold magnetic resonance (MR) technique for the direct imaging of pulmonary emboli. METHODS:In vitro MR imaging was performed to demonstrate the potential generation of clot-blood contrast by in vivo pulmonary embolism (PE). A two-dimensional magnet...

journal_title：Investigative radiology

authors： Moody AR,Liddicoat A,Krarup K

更新日期：1997-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To demonstrate the usefulness of a model of the parenchymous vascularization to evaluate texture analysis methods. METHODS:Slices with thickness varying from 1 to 4 mm were reformatted from a 3D vascular model corresponding to either normal tissue perfusion or local hypervascularization. Param...

journal_title：Investigative radiology

authors： Rolland Y,Bézy-Wendling J,Duvauferrier R,Coatrieux JL

更新日期：1999-03-01 00:00:00

abstract：:Receiver operating characteristic (ROC) analysis has been used in a broad variety of medical imaging studies during the past 15 years, and its advantages over more traditional measures of diagnostic performance are now clearly established. But despite the essential simplicity of the approach, workers in the field ofte...

journal_title：Investigative radiology

authors： Metz CE

更新日期：1989-03-01 00:00:00

abstract：:Simultaneous inflation of two balloons may be necessary for balloon dilation valvuloplasty in patients with a large annulus. We examined the cardiovascular effects of dilating the pulmonary annulus with two balloons in 18 normal dogs using pulsed Doppler ultrasound and gross and microscopic examination. When the ratio...

journal_title：Investigative radiology

authors： Butto F,Burke B,Berry JM,Amplatz K,Bass JL

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:To investigate image quality and interstudy reproducibility of aortic atherosclerosis imaging at 1.5 T, and to explore the impact of parallel imaging techniques at 3 T. MATERIALS AND METHODS:Institutional review board approval and informed consent were obtained. Thirty-two subjects (20 normal, 12 patients w...

journal_title：Investigative radiology

authors： Maroules CD,McColl R,Khera A,Peshock RM

更新日期：2008-09-01 00:00:00

abstract：:Recent publications of the magnetic resonance safety profile of neurostimulators, cardiac pacemakers, and other implanted devices imply that these devices are no longer a contraindication for magnetic resonance imaging. It is very promising that patients who have these implanted devices may in the future no longer be ...

journal_title：Investigative radiology

authors： Nitz WR,Brinker G,Diehl D,Frese G

更新日期：2005-12-01 00:00:00