Abstract:
RATIONALE AND OBJECTIVES:The authors investigated whether gadolinium-ethoxybenzyl-DTPA (Gd-EOB-DTPA) can be eliminated in the absence of the two usual excretory pathways (urinary or biliary) and whether a remaining excretory pathway is able to compensate for impaired liver or kidney function. METHODS:The study was performed using two groups of animals: group A animals underwent ligation of the common bile duct, and group B animals underwent ligation of the renal blood vessels. A dose of 0.1 mmol/kg Gd-EOB-DTPA or Gd-DTPA (control) was injected via a tail vein. Bile or urine were collected in fractions of 0 to 1, 1 to 2, 2 to 4, and 4 to 8 hours after administration of either contrast agent. At the end of the experiments, detainment of the contrast agents was determined by measurement of Gd concentrations. RESULTS:Most of the Gd-EOB-DTPA was rapidly cleared from the body: 89.4% +/- 7.5% of the injected dose within 4 hours after bile duct ligation (group A) and 87.0% +/- 6.0% within 1 hour after ligation of renal vessels (group B). Eight hours after injection of Gd-EOB-DTPA, 3.0% +/- 2.4% of the administered dose of this contrast agent was found in the carcasses of group A animals, and 1.3% +/- 0.6% in carcasses of group B animals. By comparison, at 8 hours after injection, 1.9% +/- 3.2% of the injected Gd-DTPA was found in the carcasses of group A animals (no statistical significant difference as compared with Gd-EOB-DTPA), and 96.3% +/- 3.3% in carcasses of group B animals. CONCLUSIONS:In the rat model, the magnetic resonance imaging contrast agent Gd-EOB-DPTA is rapidly and effectively eliminated by virtue of its dual-elimination pathway. The dysfunction of liver or kidney may be fully compensated by the remaining elimination pathway.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Mühler A,Heinzelmann I,Weinmann HJdoi
10.1097/00004424-199402000-00017subject
Has Abstractpub_date
1994-02-01 00:00:00pages
213-6issue
2eissn
0020-9996issn
1536-0210journal_volume
29pub_type
杂志文章abstract::Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of new nonionic contrast media is presented. ...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:To estimate the sensitivity to find small coronary artery calcium lesions with use of different slice widths with electron beam tomography. MATERIALS AND METHODS:Two studies were performed. Study 1 utilized double scanning of a stationary cork phantom with three different slice thickness (1.5, ...
journal_title:Investigative radiology
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abstract:RATIONALE AND OBJECTIVES:To evaluate different vein graft-coated stent systems in the endovascular treatment of experimental arteriovenous fistulae (AVF) in a canine model. METHODS:Bilateral carotid-to-external jugular vein AVF were created. Two balloon-expandable tantalum stents (Strecker stent), two self-expanding n...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199901000-00004
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abstract:RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared fro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199603000-00003
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abstract:RATIONALE AND OBJECTIVES:Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this article, the unique adaptations of MRM required in the study of caro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199409000-00004
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abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000064
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000117881.42422.72
更新日期:2004-05-01 00:00:00
abstract::Electromagnetic flow measurement study was performed in 20 anesthetized dogs to evaluate the effect of selective celiac infusion of vasopressin on the hepatic arterial vasculature. Teh hepatic arterial flow showed a biphasic response with an initial decrease followed by a substantial increase in spite of a continued ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
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abstract:RATIONALE AND OBJECTIVES:The authors determine the relative effect of soft-tissue compartments, body fat (percent [%Bfat] and weight [Bfat kg]) and fat-free mass (FFM kg), on measurements of ultrasound bone velocity (UBV m/second). METHODS:The authors measured UBV in proximal phalanxes and body fat and fat-free mass b...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199710000-00005
更新日期:1997-10-01 00:00:00
abstract::Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198803000-00006
更新日期:1988-03-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000697
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更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197807000-00005
更新日期:1978-07-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199307000-00011
更新日期:1993-07-01 00:00:00
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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doi:10.1097/00004424-200301000-00006
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journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199107000-00003
更新日期:1991-07-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e3181b66d11
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pub_type: 杂志文章,随机对照试验
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abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...
journal_title:Investigative radiology
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更新日期:1978-07-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e3182823591
更新日期:2013-07-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197903000-00003
更新日期:1979-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Low-field magnetic resonance imaging (MRI) evaluation of breast implants is described, with emphasis on the capabilities provided by different imaging sequences. METHODS:Open architecture MR images using a .064-T permanent magnet and three-dimensional Fourier transform and inversion recovery s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199408000-00009
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