Granulocyte accumulation in the transplanted liver does not correlate with clinical and histologic evidence of dysfunction.

Abstract:

RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared from eight patients 12 to 24 hours after orthotopic liver transplantation. The granulocytes were labeled with indium-111 (111In) oxine and reinjected. Total body radionuclide images were performed. Liver uptake of granulocytes was compared with biochemical and histologic evidence of liver injury. RESULTS:No correlation was found between liver uptake of granulocytes, as measured by geometric mean counts, and the biochemical or histologic measures of liver injury. Liver uptake of 111In was 9.6% for the patient who had liver dysfunction and 10.4% mean of the study group. This technique did not detect early signs of liver dysfunction. CONCLUSIONS:This investigation supports the premise that granulocytes do not play a major role in reperfusion injury of the newly transplanted liver graft.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Ziser A,Forstrom LA,Plevak DJ,Sanchez-Urdazpal L,Gores GJ,Wiesner RH,Batts KP,Krom RA

doi

10.1097/00004424-199603000-00003

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

132-7

issue

3

eissn

0020-9996

issn

1536-0210

journal_volume

31

pub_type

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