Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents.

Abstract:

RATIONALE AND OBJECTIVES:Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis. METHODS:DCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor's extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp<-->t/VT). RESULTS:For Gd-DTPA ve = 9% to 13% Kp<-->t/VT = 0.01 to 0.06 minutes-1, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp<-->t/VT = 0.008 to 0.04 minutes(-1). Significant differences in Kp<-->t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range. CONCLUSIONS:Smaller ROI values or pixels should yield more accurate assessment of neovascularization.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Aref M,Brechbiel M,Wiener EC

doi

10.1097/00004424-200204000-00003

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

178-92

issue

4

eissn

0020-9996

issn

1536-0210

journal_volume

37

pub_type

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