Digital mammography using iodine-based contrast media: initial clinical experience with dynamic contrast medium enhancement.

Abstract:

PURPOSE:We sought to evaluate the potential of dynamic contrast enhancement after the intravenous administration of an iodine-based contrast medium in full-field digital mammography. MATERIAL AND METHODS:A protocol for image acquisition was established for contrast-enhanced mammography and the mammography unit (Senographe 2000D, GE Healthcare, Buc, France) changed as required. The effect of the protocol parameters on imaging was investigated. Subsequently, 21 patients with 25 suspicious lesions of the breast (10 benign, 1 borderline, and 14 malignant) underwent mammography with administration of an iodine-based contrast medium (Ultravist 370, Schering AG, Berlin, Germany), after approval of ethical committee as well as permission of German federal office for Radiation protection, and informed consent from each patient was obtained. Three sequential digital mammographic images of the respective breast were acquired after administration of the contrast medium at a dose of 1 mL/kg body weight and a flow of 4 mL/s. The postcontrast images were acquired 60, 120, and 180 seconds after administration. Subsequently, the precontrast image was logarithmically subtracted from the postcontrast images. Enhancement of the lesions was measured in absolute terms as well as relative to the enhancement of the glandular tissue. The subtracted images were evaluated for lesion depiction and dynamic contrast enhancement. Lesion-enhancement kinetics were compared with the histologic findings. RESULTS:All malignant lesions were identified on the contrast-enhanced images of digital mammography. Three of the tumors (2 malignant, 1 benign) were detected only by contrast-enhanced mammography and not by standard mammography. Dynamic enhancement curves of benign and malignant tumors in contrast-enhanced mammography look similar to the curves known from gadolinium-enhanced magnetic resonance imaging. Nevertheless differentiation between malignant and benign tumors based on the enhancement patterns cannot be directly taken over from magnetic resonance imaging, as suggested by our initial results. The results are somewhat better when tumor enhancement relative to surrounding glandular tissue is used instead of absolute enhancement. CONCLUSION:The results of this preliminary study suggest that contrast-enhanced digital mammography is a potentially useful tool for the detection and the differentiation of benign and malignant breast lesions.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Diekmann F,Diekmann S,Jeunehomme F,Muller S,Hamm B,Bick U

doi

10.1097/01.rli.0000167421.83203.4e

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

397-404

issue

7

eissn

0020-9996

issn

1536-0210

pii

00004424-200507000-00002

journal_volume

40

pub_type

杂志文章
  • Pancreatic Steatosis Is Associated With Impaired Exocrine Pancreatic Function.

    abstract:OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000554

    authors: Kromrey ML,Friedrich N,Hoffmann RT,Bülow R,Völzke H,Weiss FU,Lerch MM,Motosugi U,Kühn JP

    更新日期:2019-07-01 00:00:00

  • High-resolution magnetic resonance imaging at 2 Tesla: potential for atherosclerotic lesions exploration in the apolipoprotein E knockout mouse.

    abstract:INTRODUCTION:The aim of the present study was to evaluate the potential of high-resolution MRI at 2 Tesla (T) for direct noninvasive imaging of the aortic wall in a mouse model of atherosclerosis. MATERIAL AND METHODS:A specific mouse antenna was developed and sequence parameters were adjusted. T(1)- and T2-weighted i...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000067491.31978.1c

    authors: Chaabane L,Soulas EC,Contard F,Salah A,Guerrier D,Briguet A,Douek P

    更新日期:2003-08-01 00:00:00

  • Toward clinical X-ray phase-contrast CT: demonstration of enhanced soft-tissue contrast in human specimen.

    abstract:OBJECTIVES:X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a convent...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181e21866

    authors: Donath T,Pfeiffer F,Bunk O,Grünzweig C,Hempel E,Popescu S,Vock P,David C

    更新日期:2010-07-01 00:00:00

  • Hybrid Positron Emission Tomography/Magnetic Resonance Imaging: Challenges, Methods, and State of the Art of Hardware Component Attenuation Correction.

    abstract::Attenuation correction (AC) is an essential step in the positron emission tomography (PET) data reconstruction process to provide accurate and quantitative PET images. The introduction of PET/magnetic resonance (MR) hybrid systems has raised new challenges but also possibilities regarding PET AC. While in PET/computed...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/RLI.0000000000000289

    authors: Paulus DH,Quick HH

    更新日期:2016-10-01 00:00:00

  • Safety and Oncologic Outcomes of Magnetic Resonance Imaging-Guided Cryoablation of Renal Cell Carcinoma: A 10-Year Single-Center Experience.

    abstract:OBJECTIVES:Magnetic resonance imaging guidance has been sporadically reported for renal tumor cryoablation (CA); therefore, clinical experience with this modality is still limited.The aim of this study is to retrospectively analyze our 10-year experience with renal tumor CA performed on a 1.5 T magnetic resonance imagi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000719

    authors: Cazzato RL,De Marini P,Leonard-Lorant I,Leclerc L,Auloge P,Tricard T,Dalili D,Garnon J,Lang H,Gangi A

    更新日期:2020-09-04 00:00:00

  • Comparison of Power Versus Manual Injection in Bolus Shape and Image Quality on Contrast-Enhanced Magnetic Resonance Angiography: An Experimental Study in a Swine Model.

    abstract:OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000383

    authors: Tsuboyama T,Jost G,Pietsch H,Tomiyama N

    更新日期:2017-09-01 00:00:00

  • Validation of ultrafast computed tomographic left ventricular volume measurement.

    abstract::Left ventricular volume has been measured with ultrafast computed tomography. However, the accuracy with which this can be done is unknown. We therefore imaged with ultrafast computed tomography 11 rectangular phantoms, 20 to 225 ml, and 17 left ventricular casts, 15 to 112 ml. Two observers planimetered serial tomogr...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199101000-00006

    authors: Pietras RJ,Wolfkiel CJ,Veselik K,Roig E,Chomka EV,Brundage BH

    更新日期:1991-01-01 00:00:00

  • Helium3 polarization using spin exchange technique: application to simultaneous pulmonary ventilation/perfusion imaging in small animals.

    abstract:RATIONALE AND OBJECTIVES:To develop a simple and robust helium3 polarization system dedicated to small animal imaging. To demonstrate the potential of helium3 imaging for pulmonary ventilation and perfusion studies. METHODS:A home-built polarization system based on spin-exchange technique was used. This system was app...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Stupar V,Berthezène Y,Canet E,Tournier H,Dupuich D,Crémillieux Y

    更新日期:2003-06-01 00:00:00

  • Noninvasive measurement of an index of renal blood flow.

    abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198307000-00009

    authors: Powers TA,Rees RS,Bowen RD

    更新日期:1983-07-01 00:00:00

  • Structured Reporting of Rectal Magnetic Resonance Imaging in Suspected Primary Rectal Cancer: Potential Benefits for Surgical Planning and Interdisciplinary Communication.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000336

    authors: Nörenberg D,Sommer WH,Thasler W,DʼHaese J,Rentsch M,Kolben T,Schreyer A,Rist C,Reiser M,Armbruster M

    更新日期:2017-04-01 00:00:00

  • Contrast-to-noise-ratio measurements in three-dimensional magnetic resonance angiography.

    abstract:RATIONALE AND OBJECTIVES:The authors report on the development and preliminary validation of a technique for measuring contrast-to-noise ratio (CNR) at all points along selected vessel segments in the original three-dimensional magnetic resonance angiography (MRA) dataset. METHODS:Contrast-to-noise ratio dependencies ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199311000-00005

    authors: Du Y,Parker DL,Davis WL,Blatter DD

    更新日期:1993-11-01 00:00:00

  • Biodistribution and excretion of 125I ioversol in conscious dogs.

    abstract::Radiolabeled ioversol was injected intravenously into two male and two female beagle dogs (6.7 to 10.4 kg) at two dose levels each (0.2 and 1.0 g I/kg). Blood levels of radioactivity were monitored at 2, 5, 10, 20, 40, 60, 90, and 120 minutes and at one and two days. Urine and feces were collected in metabolism cages ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198906001-00005

    authors: Coveney JR,Robbins MS

    更新日期:1989-06-01 00:00:00

  • Necrotic areas in VX2 carcinoma of rabbits. Correlation of magnetic resonance imaging and pathologic appearance.

    abstract:RATIONALE AND OBJECTIVES:To assess the potential of magnetic resonance imaging (MRI) for evaluating the evolution of tumor necrosis, the authors evaluated 28 VX2 carcinomas inoculated in the thigh muscles of rabbits. METHODS:MRI of VX2 carcinomas at 2.0 T was done with spin-echo technique 1 week (14 tumors) and 3 week...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199301000-00010

    authors: Choi BI,Lee DH,Han MC

    更新日期:1993-01-01 00:00:00

  • Nonenhanced magnetic resonance angiography of the lower extremity vessels at 7 tesla: initial experience.

    abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of nonenhanced magnetic resonance angiography (MRA) of the lower extremities at 7 tesla (T). MATERIALS AND METHODS:Eight healthy volunteers were examined on a 7-T whole-body magnetic resonance system. For image acquisition, a custom-built 16-channel t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182839c2b

    authors: Fischer A,Maderwald S,Orzada S,Johst S,Schäfer LC,Ladd ME,Nassenstein K,Umutlu L,Lauenstein TC

    更新日期:2013-07-01 00:00:00

  • Long-term effect of irradiation on lymph node uptake of interstitially delivered nanoparticulate contrast media.

    abstract:RATIONALE AND OBJECTIVES:To characterize the long-term effects of therapeutic doses of ionizing radiation on the uptake and distribution of percutaneously delivered particulate contrast media in normal lymph nodes. METHODS:Two milliliters of an iodinated nanoparticle suspension (76 mg I/mL) was injected subcutaneously...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200003000-00007

    authors: Wisner ER,Théon A,Griffey SM,McIntire GL

    更新日期:2000-03-01 00:00:00

  • Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP.

    abstract:OBJECTIVE:To investigate the efficacy of true fast imaging with steady state precession (true-FISP) compared with T2-weighted fast spin echo (T2W-FSE) in monitoring changes in cyst volume and renal expansion in an ischemia reperfusion (IR) injured PKD1 knockout (IKO) mouse model. MATERIALS AND METHODS:The animal study...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181be3501

    authors: Zhou X,Bao H,Takakura A,Zhou J,Albert M,Sun Y

    更新日期:2010-01-01 00:00:00

  • Analysis of radiocontrast-induced nephropathy by dual-labeled radionuclide clearance.

    abstract:RATIONALE AND OBJECTIVES:This study was devised to develop a method of measuring the acute effects of radiocontrast media on renal function and assessing the relationship of the dose of radiocontrast media infused with the incidence of radiocontrast-induced renal failure. In addition, the drug adenosine phosphate-magne...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199406000-00004

    authors: Albert SG,Shapiro MJ,Brown WW,Goodgold H,Zuckerman D,Durham R,Kern M,Fletcher J,Wolverson M,Plummer ES

    更新日期:1994-06-01 00:00:00

  • Low tube voltage improves computed tomography imaging of delayed myocardial contrast enhancement in an experimental acute myocardial infarction model.

    abstract:OBJECTIVE:We sought to evaluate the influence of tube voltage on the visualization of acute myocardial infarction (MI) in cardiac multislice spiral computed tomography (MSCT). MATERIALS AND METHODS:Acute MI was induced in 12 domestic pigs by a 45-minute balloon occlusion of the left anterior descending artery. Delayed...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000251577.68223.84

    authors: Mahnken AH,Bruners P,Mühlenbruch G,Emmerich M,Hohl C,Günther RW,Wildberger JE

    更新日期:2007-02-01 00:00:00

  • Hemodynamic effect of iodinated high-viscosity contrast medium in the rat kidney: a diffusion-weighted MRI feasibility study.

    abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200011000-00001

    authors: Laissy JP,Menegazzo D,Dumont E,Piekarski JD,Karila-Cohen P,Chillon S,Schouman-Claeys E

    更新日期:2000-11-01 00:00:00

  • Clinical image quality assessment of accelerated magnetic resonance neuroimaging using compressed sensing.

    abstract:PURPOSE:The aim of this study was to determine to what degree current compressed sensing methods are capable of accelerating clinical magnetic resonance neuroimaging sequences. METHODS:Two 2-dimensional clinical sequences were chosen for this study because of their long scan times. A pilot study was used to establish ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31828a012d

    authors: Sharma SD,Fong CL,Tzung BS,Law M,Nayak KS

    更新日期:2013-09-01 00:00:00

  • Toward the Clinical Development and Validation of a Thy1-Targeted Ultrasound Contrast Agent for the Early Detection of Pancreatic Ductal Adenocarcinoma.

    abstract::Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted microbubble (MBThy1) contrast agent that specifically recognizes Thy1 antigen overexpressed in the vasculature of...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000697

    authors: Bam R,Daryaei I,Abou-Elkacem L,Vilches-Moure JG,Meuillet EJ,Lutz A,Marinelli ER,Unger EC,Gambhir SS,Paulmurugan R

    更新日期:2020-11-01 00:00:00

  • Photon scattering measurement of calcaneal bone density: result of in vivo cross-sectional studies.

    abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198201000-00004

    authors: Roberts JG,DiTomasso E,Webber CE

    更新日期:1982-01-01 00:00:00

  • Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine.

    abstract:OBJECTIVE:To determine the prevalence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) who have received gadopentetate dimeglumine. MATERIALS AND METHODS:We retrospectively studied all patients who underwent contrast-enhanced magnetic resonance imagings (CE-MRIs) between January 1, ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31819343ba

    authors: Hope TA,Herfkens RJ,Denianke KS,LeBoit PE,Hung YY,Weil E

    更新日期:2009-03-01 00:00:00

  • Whole-body diffusion-weighted imaging with apparent diffusion coefficient mapping for treatment response assessment in patients with diffuse large B-cell lymphoma: pilot study.

    abstract:OBJECTIVES:The aim of this pilot study was to assess post-treatment apparent diffusion coefficient (ADC) changes of diffuse large B-cell lymphoma lesions on respiratory-gated whole-body diffusion-weighted imaging (DWI), with integrated (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182087b03

    authors: Lin C,Itti E,Luciani A,Zegai B,Lin SJ,Kuhnowski F,Pigneur F,Gaillard I,Paone G,Meignan M,Haioun C,Rahmouni A

    更新日期:2011-05-01 00:00:00

  • Assessment of preoperative magnetic resonance imaging staging in patients with hepatocellular carcinoma undergoing resection compared with the seventh American Joint Committee on Cancer System.

    abstract:OBJECTIVES:The aim of this study was to compare the prognostic utility of a staging system using magnetic resonance imaging (MRI) with the seventh American Joint Committee on Cancer (AJCC) staging system in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection. MATERIALS AND METHODS:A total of 1...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182630e8d

    authors: An C,Choi GH,Lee HS,Kim MJ

    更新日期:2012-11-01 00:00:00

  • Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 T.

    abstract:PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000577

    authors: Szomolanyi P,Rohrer M,Frenzel T,Noebauer-Huhmann IM,Jost G,Endrikat J,Trattnig S,Pietsch H

    更新日期:2019-09-01 00:00:00

  • Incidence of nephrogenic systemic fibrosis in patients undergoing dialysis after contrast-enhanced magnetic resonance imaging with gadolinium-based contrast agents: the Prospective Fibrose Nephrogénique Systémique study.

    abstract:BACKGROUND:Nephrogenic systemic fibrosis (NSF) has been related to the use of gadolinium-based contrast agents (GBCAs) in patients undergoing dialysis. The Prospective Fibrose Nephrogénique Systémique study, a French prospective study supported by the French drug regulatory agency (Agence Nationale de Sécurité du Médic...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/RLI.0000000000000000

    authors: Amet S,Launay-Vacher V,Clément O,Frances C,Tricotel A,Stengel B,Gauvrit JY,Grenier N,Reinhardt G,Janus N,Choukroun G,Laville M,Deray G

    更新日期:2014-02-01 00:00:00

  • The effect of some iodinated contrast media on human plasma butyrylcholinesterase activity.

    abstract::The effect of three iodinated contrast media (CM) on human plasma butyrylcholinesterase (BuChE) activity was studied during the intravenous pyelography (i.v.P). BuChE is an enzyme that participates in the metabolism of acetylcholine and hydrolyzes food esters and drugs such as nondepolarizing muscle relaxants and loca...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199805000-00008

    authors: Mironidou M,Ximitidou O,Christopoulos S,Kokkas B

    更新日期:1998-05-01 00:00:00

  • Contrast media tonicity. Part I. Effects upon IV-DSA time-concentration curve peak and width: experimental studies.

    abstract::Prior to the formation of an intravenous digital subtraction angiography (IV-DSA) image, contrast medium passes through the lesser circulation and is diluted by the blood volume of the heart and lungs. If the contrast medium alone influences central blood volume or cardiac output, the shape of the resultant time-conce...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198603000-00009

    authors: Burbank FH,Thompson WM

    更新日期:1986-03-01 00:00:00

  • Computed tomography of the normal radioulnar joints.

    abstract::Computed tomography followed by sectional radiography and photography as performed on eight cadaveric specimens in order to define the anatomy and normal motion of both the proximal and the distal radioulnar articulations. Osseous landmarks were defined that allowed measurement of rotation at the glenohumeral, proxima...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198311000-00012

    authors: Cone RO,Szabo R,Resnick D,Gelberman R,Taleisnik J,Gilula LA

    更新日期:1983-11-01 00:00:00