Abstract:
RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion microimaging were investigated in studying human atherosclerotic arteries. Strong diffusion weighting and high spatial resolution was achieved by means of a strong dedicated gradient system and a small birdcage radiofrequency resonator. RESULTS:Quantitative parameter maps were obtained at voxel sizes down to 73 x 73 x 600 microm3. The morphologic structure and pathology connected to lipid deposits, plaques, small thrombi, and bifurcations were well visualized. CONCLUSION:High-resolution parameter-weighted and parameter-imaging at sub-100-microm pixel resolution can be achieved for excised tissue on a 3.0 T whole body MR system. Perspectives for the characterization of atherosclerotic plaques imply not only cost advantages but also equivalence of contrast, especially as to T(2), for in vivo and high-resolution ex vivo investigations on the same MR scanner.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Berg A,Sailer J,Rand T,Moser Edoi
10.1097/01.RLI.0000068620.17569.83keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
452-9issue
7eissn
0020-9996issn
1536-0210journal_volume
38pub_type
杂志文章abstract::The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199108000-00009
更新日期:1991-08-01 00:00:00
abstract::A method is presented by whichcomputed tomography scans carried out at a number of energies may be utilized to obtain cross-sectional images of density and atomic number in addition to the conventional array of linear attenuation coefficients. This type of analysis has been carried out for various substances of biolog...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197703000-00016
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVES:Volumetric magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) is a completely noninvasive image-guided thermal ablation technique. Recently, there has been growing interest in the use of MR-HIFU for noninvasive ablation of malignant tumors. Of particular interest for noninvasive ablation...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182820257
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000642
更新日期:2020-05-01 00:00:00
abstract::The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 mg/dl and of tetracycline was 4.6 micrograms/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198605000-00005
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31822311a9
更新日期:2011-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied the long-term distribution of gadolinium (Gd) in mice and rats after the administration of four commercially available magnetic resonance imaging contrast media. The goals were to determine any possible product dissociation in vivo and to evaluate the effects that product ex...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199506000-00008
更新日期:1995-06-01 00:00:00
abstract::A silicone gel phantom material is described. It can be molded into any shape and it can contain internal cavities. The material is selfsealing allowing the cavities to be filled with liquids. A simple geometric phantom consisting of a rectangular solid with a single internal spherical cavity was fabricated and imaged...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198702000-00013
更新日期:1987-02-01 00:00:00
abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198201000-00004
更新日期:1982-01-01 00:00:00
abstract::The developing trend for all medical images to be in digital form raises an important question: should diagnostic interpretations be made directly from a CRT or from some form of hard copy recording of the CRT? This question was studied by having two observers read a series of digital images of the thyroid including b...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198305000-00015
更新日期:1983-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Paclitaxel added to angiographic contrast medium (CM) has been shown to inhibit restenosis in the porcine coronary overstretch model. This study determined early local tissue concentrations after the administration of different paclitaxel doses and preparations. MATERIALS AND METHODS:Fifteen p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000116125.96544.64
更新日期:2004-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Ultrasound can cause destruction of microbubble contrast agents used to enhance medical ultrasound imaging. This study sought to characterize the dynamics of this interaction by direct visual observation of microbubbles during insonification in vitro by a medical ultrasound imaging system. MET...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199812000-00004
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To investigate the correlation between intravoxel incoherent motion (IVIM) model-derived parameters and histologically determined microvascularity in pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:From April 2013 to May 2014, 42 patients with mal...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000187
更新日期:2015-11-01 00:00:00
abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198211000-00007
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVES:The aim of this pilot study was to assess post-treatment apparent diffusion coefficient (ADC) changes of diffuse large B-cell lymphoma lesions on respiratory-gated whole-body diffusion-weighted imaging (DWI), with integrated (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182087b03
更新日期:2011-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS:The device consists of a symmetrical cage of six superelastic monofile wires, including a mic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199702000-00003
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:To test the feasibility of a single MR-based examination allowing for the comprehensive assessment of renal anatomy, function, and vascular status in candidates for kidney transplantation. MATERIALS AND METHODS:Twelve healthy potential kidney donors (mean age: 47 +/- 14 [standard deviation] years, 3 men and...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/RLI.0b013e3181b35a70
更新日期:2009-11-01 00:00:00
abstract::The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to demonstrate feasibility of measuring extracellular pH in cartilage and meniscus using acidoCEST technique with a 3-dimensional ultrashort echo time readout (acidoCEST-UTE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Magnetization transfer ratio asymmetry, radiofrequ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000576
更新日期:2019-09-01 00:00:00
abstract::The Point Spread Function (PSF) in NMR imaging is the result of both the line broadening due to magnet field inhomogeneity and the intrinsic spectrum of the nucleus at resonance. In the case of proton imaging, the line broadening dominates the small chemical shifts and the spectral lines are not resolved. This is not ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198503000-00016
更新日期:1985-03-01 00:00:00
abstract::The study aim was to define potential differences and advantages in magnetic resonance (MR) patterns of tumoral contrast enhancement using either a small molecular, extracellular fluid contrast enhancer [Gd-DTPA] or a macromolecular agent [albumin-(Gd-DTPA)20], designed for primary intravascular biodistribution. MR im...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198908000-00007
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers. MATERIALS AND METHODS:One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectivel...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000569
更新日期:2019-08-01 00:00:00
abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198711000-00001
更新日期:1987-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the influence of injection rates and volumes on the arrival time of contrast material (CM) in the common carotid artery, the jugular vein and the resulting arterial-venous transit time. Additionally the relationship between injection parameters and the extent of a CM plateau was evalu...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.rli.0000105040.40925.c8
更新日期:2004-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:As part of a general examination of the effect of blood flow patterns on the growth and risk of rupture of abdominal aortic aneurysms, the authors investigated the flow through an experimental model of a fusiform aneurysm. MATERIALS AND METHODS:Aneurysms were simulated in polyvinyl chloride tu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199207000-00008
更新日期:1992-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Very small dextran-coated magnetite particles were developed. These particles can be used either as immunospecific contrast agents for MRI by coupling to antibodies or as an interstitial contrast agent. METHODS:The particles were synthesized from iron chloride/dextran solutions. Size was evalu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200009000-00006
更新日期:2000-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Gd-DTPA is a well-characterized, safe contrast agent frequently used in magnetic resonance imaging (MRI) of the central nervous system. The purpose of this double-blind, comparative MRI study of brain, spine, trunk, and limbs was to evaluate the safety and efficacy of Gd-DOTA versus Gd-DTPA in ...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199502000-00002
更新日期:1995-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study evaluating a cesium iodide-amorphous silicon-based flat-panel detector was to optimize the x-ray spectrum for chest radiography combining excellent contrast-detail visibility with reduced patient exposure. MATERIALS AND METHODS:A Lucite plate with 36 drilled holes of ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000138091.96320.f8
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To quantify independent pharmacokinetic parameters for differentiation of prostate pathology. MATERIAL AND METHODS:Twenty-seven patients with biopsy-proven prostate cancer (PSA: 1.4-16.1 ng/mL) underwent magnetic resonance imaging with a new dynamic contrast-enhanced, inversion-prepared dual-contrast gradien...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816b2f63
更新日期:2008-07-01 00:00:00