Magnetic resonance imaging-histologic correlation of small hepatocellular carcinomas adenomatous hyperplasias.

Abstract:

RATIONALE AND OBJECTIVES:Hepatocellular carcinomas (HCCs) usually consist of components of different histologic grade. Using surgically resected specimens, the authors obtained high-resolution magnetic resonance (MR) images and studied the relationship between histologic grade of HCCs and MR signal intensity. METHOD:In vitro MRI was performed on 15 small (less than 20-mm diameter) HCCs and 2 patients with adenomatous hyperplasia (AH) within 1 hour of surgical resection. In these 17 lesions, 24 macroscopic nodular components corresponding to MR images were recognized pathologically. The difference in MR signal intensity was examined by using tumor/phantom (T/P) signal-intensity ratio. In addition, the correlations between signal intensity on MRI and histologic criteria for grading HCC were studied. RESULTS:On T2-weighted images, grade II HCCs had significantly greater T/P values than grade I HCCs (P < .01). There is the correlation (r = .88, P < .001) between nucleocytoplasmic (N/C) ratio and signal intensity of small HCCs and AHs on T2-weighted images. CONCLUSION:The N/C ratio is an important factor relating the signal intensity to the histologic grade of these lesions on T2-weighted images.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Inoue E,Kuroda C,Narumi Y,Fujita M,Kadota T,Kuriyama K,Yoshioka H,Ishiguro S,Sasaki Y,Imaoka S

doi

10.1097/00004424-199308000-00007

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

691-7

issue

8

eissn

0020-9996

issn

1536-0210

journal_volume

28

pub_type

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