Abstract:
:The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a fluid isoviscous to blood. Dye concentration in each of 16 HA branches was determined by photospectrometry. Dye infusion was carried out through 2-2.5F double lumen end hole or proximal side hole balloon catheters without balloon inflation, with balloon inflation maintaining full HA flow, and with the balloon inflated so that HA flow was reduced by 50%. The measurements taken without balloon inflation showed gross inhomogeneity of dye concentration in various branches. The inhomogeneity was not improved during balloon inflation as long as full HA flow was maintained. After balloon inflation reduced HA flow by 50%, dye mixing was improved significantly, with infusion through side hole catheters (alpha = .002) but not significantly (alpha = .2) with infusion through end hold catheters. This investigation suggests that the proposed technique might be useful for clinical application and deserves further evaluation in an in vivo system.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Barth KH,Lutz RJ,Kremers PW,Miller DLdoi
10.1097/00004424-198807000-00007subject
Has Abstractpub_date
1988-07-01 00:00:00pages
519-23issue
7eissn
0020-9996issn
1536-0210journal_volume
23pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:It is widely believed that down-sizing catheters, and possibly needles, will decrease damage to the entry vessel in the performance of angiography. The purposes of this in vitro experiment are to determine if smaller needles produce less arterial wall damage than larger needles and to assess th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00001
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000195836.57778.1f
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS:In this institutional r...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000418
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and compare the overall performance, reliability, variability, as well as the accuracy of diffusion tensor imaging (DTI) and fiber tracking metrics, for the muscles of the calf at 3 T and 7 T. MATERIALS AND METHODS:Ten volunteers (5 males; mean age, 29.1 ± 4.7 years), with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000508
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Commercially available iodinated contrast media (CM) show significantly different physico-chemical properties. The relevance of the viscosity of CM may be underestimated as a contributing factor for clinically relevant renal failure as suggested by a large registry data analysis (Swedish registry study). The ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318190fbd2
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the impact of oral water and intravenous furosemide challenges on blood oxygenation level-dependent magnetic resonance imaging measurements in the kidney and to examine the contribution of R2 (=1/T2) to changes in R2* (=1/T2*). MATERIALS AND METHODS:This Health Insurance ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182823591
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract::Thromboembolic complications occurring during angiography may result from a number of different causes. Catheters and guidewires can interact with blood to form thrombi; this tendency is related to wall defects and the chemical composition and structural characteristics of the catheters and guidewires. Nonthrombic sou...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198811002-00009
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000554
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000030
更新日期:2014-06-01 00:00:00
abstract::The efficacy and safety of perfluoroctylbromide as a diagnostic contrast agent for direct lymphography was studied in mongrel dogs. This radiopaque perfluorocarbon has several advantages over Ethiodol. The liquid compound has injection times one-fifth of that required for Ethiodol. When dosages were three to four tim...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197707000-00012
更新日期:1977-07-01 00:00:00
abstract::We developed a new, cineangiographic method to accurately measure the dynamic changes in the internal diameter of human arteries in vivo. Cine films were digitized at a spatial resolution of 4 microns/pixel, using a line image sensor. The vessel edges, with a Gaussian fit to a unilateral profile curve of the vessel, w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198909000-00005
更新日期:1989-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Because of the greatly increased cost of nonionic, low-osmolar contrast material, some practitioners reserve its use for patients at high risk for an adverse contrast reaction. The authors attempt to evaluate the proportion of low-risk outpatients--when offered a choice between the more expensi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199304000-00008
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:To demonstrate a method of assessing radiologic diagnostic agreement utilizing multiple blinded external readers. METHODS:Six body CT studies interpreted by one reader (primary reader) at the host institution were compiled with patient identifiers removed. Brief clinical histories that were available to the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181d2ee97
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tom...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000458
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of an 80-kVp protocol using a moderate concentration contrast material (MC-CM) for cerebral computed tomography angiography by comparison with a conventional 120-kVp protocol using a high concentration contrast material (HC-CM). MATERIALS AND METHODS:Attenuation values and sign...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31823076a4
更新日期:2012-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00015
更新日期:1994-03-01 00:00:00
abstract::The rates at which the paramagnetic compounds deoxyhemoglobin (Hb) and methemoglobin (MHb) form in vivo within an area of hemorrhage are unknown. The present experiment establishes the baseline concentrations and rates of change in paramagnetic hemoglobin concentrations, as well as the pH in normal heparinized and clo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199003000-00006
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. MATERIAL AND METHODS:After induction of hepatic ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318155aa2e
更新日期:2008-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the use of a new thrombus-specific ultrasound contrast agent, MRX-408, in the ultrasonic detection of thrombus in arteriovenous (AV) fistulae. METHODS:Six purpose-bred mongrels with two AV fistulae each were imaged with gray-scale ultrasound 7 weeks after graft implantation before ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200001000-00010
更新日期:2000-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the short-term effects of a new nitinol stent on canine arteries. METHODS:Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199905000-00007
更新日期:1999-05-01 00:00:00
abstract::Radiolabeled blood cells are widely used for both clinical and research studies. In vitro and in vivo studies have shown the tagging process does not significantly affect function. The labeling techniques and clinical uses of labeled leukocytes and platelets are reviewed. ...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198603000-00001
更新日期:1986-03-01 00:00:00
abstract::Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198803000-00006
更新日期:1988-03-01 00:00:00
abstract::Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of saline chase injected at 2 different rates on computed tomography (CT) angiography. MATERIALS AND METHODS:This study was approved by our institutional animal study committee. Three injection protocols were used; contrast injection (24 mL, 0.8 mL/s) without saline chase (protocol ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318032a9fe
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:BR55, a vascular endothelial growth factor receptor 2 (VEGFR2)-specific ultrasound molecular contrast agent (MCA), has shown promising results in multiple preclinical models regarding cancer imaging. In this first-in-human, phase 0, exploratory study, we investigated the feasibility and safety of the MCA for ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000362
更新日期:2017-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The capability of an indirect computed tomographic lymphography (CT-LG) using a nonionic monometric contrast medium iopamidol for visualizing breast lymphatic pathways was preliminarily tested. MATERIALS AND METHODS:In 10 female dogs, a total of 0.5 and 1 mL of undiluted iopamidol was injected...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200302000-00002
更新日期:2003-02-01 00:00:00
abstract::Lymphangiograms of canine cardiac and pulmonary efferent mediastinal lymphatics were made by cannulation and injection of Ethiodol. Injections were made singly and serially. The mediastinal lymphatics and lymph nodes, which constitute the pathways of drainage of the heart and lungs, were delineated from the point of c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00012
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000618
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31805f2682
更新日期:2007-09-01 00:00:00