Abstract:
OBJECTIVE:BR55, a vascular endothelial growth factor receptor 2 (VEGFR2)-specific ultrasound molecular contrast agent (MCA), has shown promising results in multiple preclinical models regarding cancer imaging. In this first-in-human, phase 0, exploratory study, we investigated the feasibility and safety of the MCA for the detection of prostate cancer (PCa) in men using clinical standard technology. MATERIALS AND METHODS:Imaging with the MCA was performed in 24 patients with biopsy-proven PCa scheduled for radical prostatectomy using a clinical ultrasound scanner at low acoustic power. Safety monitoring was done by physical examination, blood pressure and heart rate measurements, electrocardiogram, and blood sampling. As first-in-human study, MCA dosing and imaging protocol were necessarily fine-tuned along the enrollment to improve visualization. Imaging data were correlated with radical prostatectomy histopathology to analyze the detection rate of ultrasound molecular imaging with the MCA. RESULTS:Imaging with MCA doses of 0.03 and 0.05 mL/kg was adequate to obtain contrast enhancement images up to 30 minutes after administration. No serious adverse events or clinically meaningful changes in safety monitoring data were identified during or after administration. BR55 dosing and imaging were fine-tuned in the first 12 patients leading to 12 subsequent patients with an improved MCA dosing and imaging protocol. Twenty-three patients underwent radical prostatectomy. A total of 52 lesions were determined to be malignant by histopathology with 26 (50%) of them seen during BR55 imaging. In the 11 patients that were scanned with the improved protocol and underwent radical prostatectomy, a total of 28 malignant lesions were determined: 19 (68%) were seen during BR55 ultrasound molecular imaging, whereas 9 (32%) were not identified. CONCLUSIONS:Ultrasound molecular imaging with BR55 is feasible with clinical standard technology and demonstrated a good safety profile. Detectable levels of the MCA can be reached in patients with PCa opening the way for further clinical trials.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Smeenge M,Tranquart F,Mannaerts CK,de Reijke TM,van de Vijver MJ,Laguna MP,Pochon S,de la Rosette JJMCH,Wijkstra Hdoi
10.1097/RLI.0000000000000362subject
Has Abstractpub_date
2017-07-01 00:00:00pages
419-427issue
7eissn
0020-9996issn
1536-0210journal_volume
52pub_type
杂志文章abstract:OBJECTIVE:The aims of this study were to compare 3 contrast agents and to define feasible doses for quantitative lung perfusion imaging using the dual-bolus approach in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Ten healthy volunteers (6 males, 4 females; mean age, 23.5 yea...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000224
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers. MATERIALS AND METHODS:One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectivel...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000569
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to investigate and validate quantitative susceptibility mapping (QSM) for lesional iron quantification in cerebral cavernous malformations (CCMs). MATERIALS AND METHODS:Magnetic resonance imaging studies were performed in phantoms and 16 patients on a 3-T scanner. Susceptibility ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000043
更新日期:2014-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To test noninvasive inductive heating of implanted vascular stents as an alternative approach for reduction or prevention of neointimal hyperplasia. METHODS:Calorimetric pretests were performed to get an orientation on the different parameters of influence for inductive heating of stents. The ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000117881.42422.72
更新日期:2004-05-01 00:00:00
abstract::The authors conducted an observer performance study to compare breast lesion detection of conventional mammography (CM) with teleradiology (TE) transmitted mammograms. One hundred four abnormal, single-projection mammographic images were transmitted by teleradiology. Abnormalities included 11 cases with skin thickenin...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199010000-00007
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the effectiveness of a model-based iterative reconstruction (MBIR) in improving image quality and diagnostic performance of ultralow-dose computed tomography (ULDCT) of the lung. MATERIALS AND METHODS:The institutional review board approved this study, and all patients pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182562a89
更新日期:2012-08-01 00:00:00
abstract::Pyrroxamide [N-(1-hydroxymethyl-2,3-dihydroxypropyl)-2,2,5,5-tetramethyl pyrrolidine-1-oxyl-3-carboxyamide] is a newly tested nonionic monomeric nitroxyl compound with demonstrated effectiveness for MRI contrast enhancement at doses as low as 10(-3) M. Pyrroxamide and its hydroxylamine metabolic derivative were tested...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198808000-00013
更新日期:1988-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the changes in the microbubble population of a currently available ultrasound contrast agent (USCA) through attenuation measurements to optimize its clinical use. MATERIALS AND METHODS:The microbubble population from a galactose-based USCA (Levovist, Schering AG, Germany) was chara...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200212000-00006
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to validate quantitation of R2* and DeltaR2* measurements obtained with a 3-dimensional (3-D) multiple gradient-recalled echo (mGRE) sequence for evaluating intrarenal oxygenation in humans. MATERIALS AND METHODS:Validation was accomplished (1) by comparing R2* values with pre...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000187166.43871.fb
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000431
更新日期:2018-04-01 00:00:00
abstract::Experimental pulmonary arteritis was produced in rabbits by intravenous injection of alveolar macrophages from donor rabbits. These animals, along with matched controls, were studied with pulmonary angiography to test the hypothesis that angiography could detect the vasculitic process in life. The animals were then sa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198007000-00005
更新日期:1980-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the influence of injection rates and volumes on the arrival time of contrast material (CM) in the common carotid artery, the jugular vein and the resulting arterial-venous transit time. Additionally the relationship between injection parameters and the extent of a CM plateau was evalu...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.rli.0000105040.40925.c8
更新日期:2004-02-01 00:00:00
abstract::Prior studies of the opacification-phase effects of left ventricular (LV) injection of angiographic contrast medium (CM) on LV size and function have yielded discrepant results. A sensitive ultrasonic technique was used to measure LV dimension (Di) in 10 open-chest dogs with physiologic heart rates, and injection of s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198209000-00009
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVES:The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000484
更新日期:2018-11-01 00:00:00
abstract::Sixteen observers averaging 7.4 years experience in interpreting radiology images and 16 observers without radiology training were tested for their ability to detect low-contrast signals in structured noise backgrounds using a digital display system. No significant difference in true positives, false positives, time t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198704000-00006
更新日期:1987-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000436
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000381
更新日期:2017-10-01 00:00:00
abstract::Maximum likelihood estimation, assuming a binormal model, has been used extensively to estimate the area under receiver operating characteristic (ROC) curves and thus provide an index of diagnostic accuracy for the comparison of two imaging systems. However, in some instances, a degenerate data set results in a fitted...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199007000-00016
更新日期:1990-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To demonstrate the usefulness of a model of the parenchymous vascularization to evaluate texture analysis methods. METHODS:Slices with thickness varying from 1 to 4 mm were reformatted from a 3D vascular model corresponding to either normal tissue perfusion or local hypervascularization. Param...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199903000-00004
更新日期:1999-03-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.RLI.0000068620.17569.83
更新日期:2003-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Emulsions of perfluorocarbons (PFCs) have been tested as blood substitutes. However, evidence exists that there is long-term retention of some PFCs by the organs of the reticuloendothelial system (RES). The authors investigate organ retention of the blood substitute component, perfluorotripropy...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199208000-00012
更新日期:1992-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To present the results of two studies conducted to evaluate the pharmacokinetics and safety of iomeprol in healthy volunteers and in patients with various degrees of renal impairment. METHODS:In these two open-label, single-dose, phase I studies, a 50-mL dose of iomeprol 400 was administered i...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-200106000-00002
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:Thermal dose in tumor tissue is a key factor for regional hyperthermia (HT) combined with chemotherapy and for drug delivery using thermosensitive liposomes (TSL). It influences therapy outcome, affects the accumulation of liposomes, and triggers the content release from TSL in the target tissue. For the dev...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31818768cd
更新日期:2008-12-01 00:00:00
abstract::Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors determine the value of contrast-enhanced, three-dimensional (3D) magnetic resonance angiography (MRA) in the assessment of the renal arteries in comparison with conventional arteriography (CA). METHODS:One hundred three patients (71 m, 32 f) were evaluated with both CA and 3D MRA. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199809000-00021
更新日期:1998-09-01 00:00:00
abstract::We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the trace...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198309000-00007
更新日期:1983-09-01 00:00:00
abstract::The effect of three iodinated contrast media (CM) on human plasma butyrylcholinesterase (BuChE) activity was studied during the intravenous pyelography (i.v.P). BuChE is an enzyme that participates in the metabolism of acetylcholine and hydrolyzes food esters and drugs such as nondepolarizing muscle relaxants and loca...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199805000-00008
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear. OBJECTIVE:We investigated the factors ass...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000757
更新日期:2021-01-19 00:00:00
abstract:OBJECTIVES:The aim of this study was to perform phantom measurements to prove the feasibility of single-source dual-energy computed tomography (DECT) of the extremities using a volume scan mode. In addition, we, for the first time, wanted to determine which concentrations of monosodium urate (MSU) in gout and calcium p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000099
更新日期:2015-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors analyze the origins of the "clotting issue," the controversy that began in the 1980s when contrast media, once perceived as good flushing agents for catheters because of their assumed anticoagulant properties, came under attack for allegedly causing thromboembolism. Laboratory studi...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00