Abstract:
OBJECTIVES:The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results across heterogeneous acquisition protocols of routinely acquired clinical magnetic resonance imaging (MRI) examinations from multiple centers. MATERIALS AND METHODS:The data consisted of preoperative MRI scans (T1, T2, FLAIR, and contrast-enhanced [CE] T1) of 64 patients with an initial diagnosis of primary GB, which were acquired in 15 institutions with varying protocols. All images underwent preprocessing (coregistration, skull stripping, resampling to isotropic resolution, normalization) and were fed into an independently trained deep learning model based on DeepMedic, a multilayer, multiscale convolutional neural network for detection and segmentation of tumor compartments. Automatic segmentation results for the whole tumor, necrosis, and CE tumor were compared with manual segmentations. RESULTS:Whole tumor and CE tumor compartments were correctly detected in 100% of the cases; necrosis was correctly detected in 91% of the cases. A high segmentation accuracy comparable to interrater variability was achieved for the whole tumor (mean dice similarity coefficient [DSC], 0.86 ± 0.09) and CE tumor (DSC, 0.78 ± 0.15). The DSC for tumor necrosis was 0.62 ± 0.30. We have observed robust segmentation quality over heterogeneous image acquisition protocols, for example, there were no correlations between resolution and segmentation accuracy of the single tumor compartments. Furthermore, no relevant correlation was found between quality of automatic segmentation and volume of interest properties (surface-to-volume ratio and volume). CONCLUSIONS:The proposed approach for automatic segmentation of GB proved to be robust on routine clinical data and showed on all tumor compartments a high automatic detection rate and a high accuracy, comparable to interrater variability. Further work on improvements of the segmentation accuracy for the necrosis compartments should be guided by the evaluation of the clinical relevance.Therefore, we propose this approach as a suitable building block for automatic tumor segmentation to support radiologists or neurosurgeons in the preoperative reading of GB MRI images and characterization of primary GB.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Perkuhn M,Stavrinou P,Thiele F,Shakirin G,Mohan M,Garmpis D,Kabbasch C,Borggrefe Jdoi
10.1097/RLI.0000000000000484subject
Has Abstractpub_date
2018-11-01 00:00:00pages
647-654issue
11eissn
0020-9996issn
1536-0210journal_volume
53pub_type
杂志文章abstract:OBJECTIVES:The purposes of this study were to evaluate the reference range of quantitative computed tomography (QCT) measures of lung attenuation and airway parameter measurements in healthy nonsmoking adults and to identify sources of variation in those measures and possible means to adjust for them. MATERIALS AND ME...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318262292e
更新日期:2012-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors differentiate acute tubular necrosis from transplant rejection in patients with delayed kidney graft function using gadolinium (Gd)-DTPA enhanced magnetic resonance (MR) imaging. METHODS:Twenty-four patients after renal transplantation (10 with normal graft function, 14 with delaye...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-199606000-00009
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:Cardiac magnetic resonance imaging (MRI) at 3.0 T has recently become available and potentially provides a significant improvement of tissue contrast in T1-weighted imaging techniques relying on Gd-based contrast enhancement. Imaging at high-field strength may be especially advantageous for methods relying on...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/01.rli.0000233321.82194.09
更新日期:2006-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200011000-00001
更新日期:2000-11-01 00:00:00
abstract::Diagnostic radiology is expanding, playing an increasingly central role in patient care, which heightens the importance of radiology teaching in undergraduate medical education. This study examined the impact of increased structure and systematic evaluation on student performance in a radiology elective. The evaluatio...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00003
更新日期:1985-05-01 00:00:00
abstract::The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199108000-00009
更新日期:1991-08-01 00:00:00
abstract:PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000577
更新日期:2019-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS:In 10 experiments with mongrel dogs, the contrast agents were alternately injected ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199212000-00011
更新日期:1992-12-01 00:00:00
abstract::Experimental pulmonary arteritis was produced in rabbits by intravenous injection of alveolar macrophages from donor rabbits. These animals, along with matched controls, were studied with pulmonary angiography to test the hypothesis that angiography could detect the vasculitic process in life. The animals were then sa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198007000-00005
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000431
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00009
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVES:The incidence of coronary artery disease has been shown to be greater in patients with calcific deposits than in those without. It has been suggested that the pattern of distribution of coronary calcific deposits within coronary arteries is of greater predictive value for acute coronary events than the overa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3180cc2041
更新日期:2007-11-01 00:00:00
abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the impact on metal artifacts and dose efficiency of using a tin filter in combination with high-energy threshold (TH) images of a photon-counting detector (PCD) computed tomography (CT) system. MATERIALS AND METHODS:A 3D-printed spine with pedicle screws was scanned...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000535
更新日期:2019-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00015
更新日期:1994-03-01 00:00:00
abstract::The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
更新日期:1988-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The reflux of ethanol into the peritoneal cavity during percutaneous ethanol injection therapy (PEIT) of liver neoplasms may cause pain and other side effects. This article studies the optimal injection technique to minimize the reflux of ethanol. METHODS:A technique using normal postmortem pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199211000-00008
更新日期:1992-11-01 00:00:00
abstract::Ionic (diatrizoate, ioxaglate) and nonionic (iohexol, iosimide, iopromide, and iotrolan) contrast media (CM) were evaluated for their cytogenetic effects in lymphocytes. Heparinized blood was mixed with culture medium RPMI-1640 supplemented with phytohemagglutinin, fetal calf serum, and antibiotics. Plastic tubes cont...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198611000-00006
更新日期:1986-11-01 00:00:00
abstract::The cytogenetic interactions of ionic (diatrizoate, ioxaglate) and nonionic (iohexol) contrast media (CM) with antineoplastic drugs cyclophosphamide (CPA) and carmustine (CARM) were evaluated in a rat bone marrow cell model. Male Wistar rats were anesthetized with a 6% chloral hydrate solution and divided into five gr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198805000-00011
更新日期:1988-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199504000-00003
更新日期:1995-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199204000-00008
更新日期:1992-04-01 00:00:00
abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198201000-00004
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess the feasibility of magnetic resonance cholangiography (MRC) using biliary-secreted gadoxetic acid at 7 T and to compare it with T2-weighted (w) MRC at 3 T. MATERIALS AND METHODS:Ten healthy volunteers were examined on a 7-T whole-body magnetic resonance system. T2...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000004
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diabetic patients frequently suffer contrast media-induced nephropathy. Hyperglycemia in diabetes mellitus causes gradual deterioration of glomerular mesangial cells (MCs) in the kidney. In this study, the authors investigated the response of rat MCs cultured in high-glucose medium to diatrizoa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200107000-00001
更新日期:2001-07-01 00:00:00
abstract::Attenuation correction (AC) is an essential step in the positron emission tomography (PET) data reconstruction process to provide accurate and quantitative PET images. The introduction of PET/magnetic resonance (MR) hybrid systems has raised new challenges but also possibilities regarding PET AC. While in PET/computed...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000289
更新日期:2016-10-01 00:00:00
abstract::Advances in the field of magnetic resonance (MR) as it pertains to clinical diagnostic radiology are examined in this review on the basis of publications in Investigative Radiology over the past 2 years (2005-2006). The articles published during that timeframe are discussed, organizationally wise, by anatomic region w...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/01.rli.0000250461.03245.5c
更新日期:2006-12-01 00:00:00
abstract::Radiolabeled blood cells are widely used for both clinical and research studies. In vitro and in vivo studies have shown the tagging process does not significantly affect function. The labeling techniques and clinical uses of labeled leukocytes and platelets are reviewed. ...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198603000-00001
更新日期:1986-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS:In this institutional r...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000418
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the effectiveness of a model-based iterative reconstruction (MBIR) in improving image quality and diagnostic performance of ultralow-dose computed tomography (ULDCT) of the lung. MATERIALS AND METHODS:The institutional review board approved this study, and all patients pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182562a89
更新日期:2012-08-01 00:00:00