Comparison of vascular opacification after bolus injection of iodixanol-320 iohexol-350.

Abstract:

RATIONALE AND OBJECTIVES:The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS:In 10 experiments with mongrel dogs, the contrast agents were alternately injected into the animal's left atrium, and UFCT images were obtained at four cross-sectional levels through the carotid arteries. Time-density curves were then obtained for each carotid artery and each agent. The peak height and area under the curves were compared for each agent. RESULTS:Iohexol provided significantly (P < or = .05) greater opacification, determined by paired Student's t tests. CONCLUSION:This result was predicted from the greater iodine concentration of iohexol (350 mg/mL) compared with iodixanol (320 mg/mL); the difference was greater than expected based on iodine content alone.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Gould R,Brasch RC,Sievers R,Baxter A,Aicher K

doi

10.1097/00004424-199212000-00011

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

1031-4

issue

12

eissn

0020-9996

issn

1536-0210

journal_volume

27

pub_type

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