Hepatic parenchymal changes after the intraarterial injection of lipiodol in tumor-bearing rabbits.

Abstract:

RATIONALE AND OBJECTIVES:The influence of lipiodol injection on hepatic morphology and function was investigated in 119 rabbits with hepatic VX2 tumors. METHODS:The rabbits were divided into the following three groups, according to the materials injected via the proper hepatic artery: group 1 received doxorubicin (Adriamycin [ADM]); group 2 received lipiodol (LPD); and group 3 received LPD plus ADM. Groups 2 and 3 were each divided into three subgroups, according to the dose of LPD injected (0.3, 0.6, and 1.2 mL). Non-tumorous regions in the tumor-bearing lobe and the tumor-free lobe were examined histologically; low-kilovolt x-ray studies and computed tomography (CT) also were performed in 84 rabbits. Liver function tests were performed in 35 rabbits. RESULTS:Elevation of the serum aminotransferase levels was observed after the administration of LPD. Hepatocellular degeneration was marked in the tumor-free lobe, but was much more severe in the tumor-bearing lobe in groups 2 and 3. The degree of degeneration depended on the dose of LPD. Both low-kilovolt x-ray studies and CT showed the heavy accumulation of LPD in the tumor-bearing lobe. CONCLUSIONS:The current study shows that the histologic and functional adverse effects of oily chemoembolization depend on the dose of LPD administered to the liver.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Akashi Y,Koreeda C,Mizuno T,Inoue K,Kawa SK,Tanaka Y

doi

10.1097/00004424-199302000-00009

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

128-32

issue

2

eissn

0020-9996

issn

1536-0210

journal_volume

28

pub_type

杂志文章
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