Comparison of Power Versus Manual Injection in Bolus Shape and Image Quality on Contrast-Enhanced Magnetic Resonance Angiography: An Experimental Study in a Swine Model.

Abstract:

OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-tracking technique, and thoracic-abdominal time-resolved 4-dimensional [4D] MRA) were performed after power and manual injection of gadobutrol (0.1 mmol/kg) at 2 mL/s in 12 pigs (6 sets of power and manual injections for each type of CE-MRA). For the quantitative analysis, the signal-to-noise ratio was measured on ascending aorta, descending aorta, brachiocephalic trunk, common carotid artery, and external carotid artery on the 6 sets of head-neck 3D MRA, and on ascending aorta, descending aorta, brachiocephalic trunk, abdominal aorta, celiac trunk, and renal artery on the 6 sets of thoracic-abdominal 3D MRA. Bolus shapes were evaluated on the 6 sets each of test-bolus scans and 4D MRA. For the qualitative analysis, arterial enhancement, superimposition of nontargeted enhancement, and overall image quality were evaluated on 3D MRA. Visibility of bolus transition was assessed on 4D MRA. Intraindividual comparison between power and manual injection was made by paired t test, Wilcoxon rank sum test, and analysis of variance by ranks. RESULTS:Signal-to-noise ratio on 3D MRA was statistically higher with power injection than with manual injection (P < 0.001). Bolus shapes (test-bolus, 4D MRA) were represented by a characteristic standard bolus curve (sharp first-pass peak followed by a gentle recirculation peak) in all the 12 scans with power injection, but only in 1 of the 12 scans with manual injection. Standard deviations of time-to-peak enhancement were smaller in power injection than in manual injection. Qualitatively, although both injection methods achieved diagnostic quality on 3D MRA, power injection exhibited significantly higher image quality than manual injection (P = 0.001) due to significantly higher arterial enhancement (P = 0.031) and less superimposition of nontargeted enhancement (P = 0.001). Visibility of bolus transition on 4D MRA was significantly better with power injection than with manual injection (P = 0.031). CONCLUSIONS:Compared with manual injection, power injection provides more standardized bolus shapes and higher image quality due to higher arterial enhancement and less superimposition of nontargeted vessels.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Tsuboyama T,Jost G,Pietsch H,Tomiyama N

doi

10.1097/RLI.0000000000000383

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

547-553

issue

9

eissn

0020-9996

issn

1536-0210

journal_volume

52

pub_type

杂志文章
  • Noninvasive estimation of organ weights by postmortem magnetic resonance imaging and multislice computed tomography.

    abstract:OBJECTIVE:Computed tomography (CT) and magnetic resonance imaging (MRI) are introduced as an alternative to traditional autopsy. The purpose of this study was to investigate their accuracy in mass estimation of liver and spleen. METHODS:In 44 cases, the weights of spleen and liver were estimated based on MRI and CT da...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000221323.38443.8d

    authors: Jackowski C,Thali MJ,Buck U,Aghayev E,Sonnenschein M,Yen K,Dirnhofer R,Vock P

    更新日期:2006-07-01 00:00:00

  • Activities of the Conjoint Committee. Enhancement of diagnostic radiologic research and education.

    abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199304001-00014

    authors: Putman CE,Frank JA

    更新日期:1993-04-01 00:00:00

  • Hepatic kinetics and magnetic resonance imaging of gadolinium-EOB-DTPA in dogs.

    abstract:RATIONALE AND OBJECTIVES:To measure the hepatic uptake and biliary elimination kinetics of gadolinium (Gd)-EOB-DTPA in dogs. METHOD:Two groups of four beagles each were anesthetized and given an intravenous bolus of 25 mumol/kg or 250 mumol/kg of Gd-EOB-DTPA. Blood, hepatic bile, and urine were collected over 140 minu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199604000-00005

    authors: Benness G,Khangure M,Morris I,Warwick A,Burrows P,Vogler H,Weinmann HJ

    更新日期:1996-04-01 00:00:00

  • Renal effects of bicarbonate versus saline infusion for iso- and lowosmolar contrast media in rats.

    abstract:OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31822311a9

    authors: Ladwig M,Flemming B,Seeliger E,Sargsyan L,Persson PB

    更新日期:2011-11-01 00:00:00

  • New contrast media designed for x-ray energy subtraction imaging in digital mammography.

    abstract:RATIONALE AND OBJECTIVES:In contrast-enhanced dual-energy subtraction imaging 2 images acquired postcontrast media administration at different energies are subtracted to highlight structures hidden in the absence of contrast media. X-ray spectra of the newly developed digital full-field mammography units (GE Senographe...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.RLI.0000077124.24140.bd

    authors: Lawaczeck R,Diekmann F,Diekmann S,Hamm B,Bick U,Press WR,Schirmer H,Schön K,Weinmann HJ

    更新日期:2003-09-01 00:00:00

  • The mini-fellowship in teaching. A senior resident elective.

    abstract::The residency program at the University of Pennsylvania offers a 1-month fellowship for senior residents in medical student education. Instructional philosophy, methods, and content are discussed, observed, practiced, and evaluated. Close supervision and immediate feedback provide training particularly needed by futur...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199006000-00028

    authors: Troupin RH

    更新日期:1990-06-01 00:00:00

  • In vitro complement consumption by contrast materials and analogues: reactors vs. nonreactors.

    abstract::Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198307000-00018

    authors: Siegle RL,Lieberman P,Rice MC

    更新日期:1983-07-01 00:00:00

  • Evaluation of the integrity of the blood-brain barrier after meningeal trauma.

    abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199204000-00008

    authors: Walker JD,Martin MA,Potts DG,Lemaire C,Templeton DM

    更新日期:1992-04-01 00:00:00

  • Comparative cranial CT enhancement in the normal primate.

    abstract::The application of intravenous, intrathecal, and inhalation enhancement techniques to the CT evaluation of the nonhuman primate (Papio cynocephalus/anubis) is described. The falx cerebri cortical vasculature, vein of Galen, straight sinus and tentorium cerebelli were defined with intravenous enhancement. Intrathecal C...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197901000-00014

    authors: Drayer BP,Wolfson SK Jr,Rosenbaum AE,Dujovny M,Boehnke M,Cook EE

    更新日期:1979-01-01 00:00:00

  • Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular

    abstract:OBJECTIVES:To prospectively evaluate the safety and efficacy of combined unenhanced and gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging compared with unenhanced MR imaging and triphasic contrast-enhanced spiral computed tomography (CT) for the detection and characterization of focal liver...

    journal_title:Investigative radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/RLI.0b013e3181caea5b

    authors: Ichikawa T,Saito K,Yoshioka N,Tanimoto A,Gokan T,Takehara Y,Kamura T,Gabata T,Murakami T,Ito K,Hirohashi S,Nishie A,Saito Y,Onaya H,Kuwatsuru R,Morimoto A,Ueda K,Kurauchi M,Breuer J

    更新日期:2010-03-01 00:00:00

  • Spatial resolution analysis of computed tomographic images.

    abstract::Methods are presented for the quantification of spatial resolution in x-ray computed tomographic (CT) images. Model-dependent methods are derived and compared with model independent methods for computation of the Modulation Transfer Function (MTF). These techniques are applied to phantom images of point, line, edge, a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198603000-00012

    authors: Assimakopoulos PA,Boyd DP,Jaschke W,Lipton MJ

    更新日期:1986-03-01 00:00:00

  • Role of red blood cell deformation in toxicity of contrast media in cerebral angiography.

    abstract::The authors investigated the effect on the brain of red blood cells that had been modified by contrast media. Rat blood was mixed with an equivolume of contrast media, and up to 200 microL of the mixture was infused to the internal carotid artery of the rat. Evans blue was administered intravenously to assess the inte...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198905000-00009

    authors: Miyazawa T,Nakagawa H,Oshino N

    更新日期:1989-05-01 00:00:00

  • Photon scattering measurement of calcaneal bone density: result of in vivo cross-sectional studies.

    abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198201000-00004

    authors: Roberts JG,DiTomasso E,Webber CE

    更新日期:1982-01-01 00:00:00

  • Observation on the metabolism of iopanoyl (Telepaque) glucuronide in dogs treated with antibiotics.

    abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197805000-00011

    authors: Thoeni RF,Goldberg HI,Moss AA,Lin SK,Brito AC

    更新日期:1978-05-01 00:00:00

  • Magnetization Transfer Imaging Predicts Porcine Kidney Recovery After Revascularization of Renal Artery Stenosis.

    abstract:MATERIALS AND METHODS:Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset frequencies of 600 and 1000 Hz, before and 1 month post-PTRA in 7 RVD pigs. Stenotic kidney MTR was correlated to renal perfusion, renal blood flo...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000711

    authors: Afarideh M,Jiang K,Ferguson CM,Woollard JR,Glockner JF,Lerman LO

    更新日期:2021-02-01 00:00:00

  • Effect of lumbar puncture on flow of cerebrospinal fluid.

    abstract::The rate at which isotopes descend from the cisterna magna to the lumbar subarachnoid space is highly variable. In monkeys, with and without previous lumbar puncture, transit time was measured. In animals with a previous lumbar puncture, transit times were 10 to 120 minutes; in monkeys without a previous lumbar punctu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198805000-00005

    authors: Lipman B,Palmer D,Noble J,Haughton V,Collier D

    更新日期:1988-05-01 00:00:00

  • Pathophysiology of radiocontrast nephropathy: a role for medullary hypoxia.

    abstract::Recent experimental data underlies the role of hypoxic tubular injury in the pathophysiology of radiocontrast nephropathy. Although systemic transient hypoxemia, increased blood viscosity, and a leftward shift of the oxygen-hemoglobin dissociation curve may all contribute to intrarenal hypoxia, imbalance between oxyge...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199911000-00004

    authors: Heyman SN,Reichman J,Brezis M

    更新日期:1999-11-01 00:00:00

  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Quantitative Lung Perfusion Imaging Using the Dual-Bolus Approach: Comparison of 3 Contrast Agents and Recommendation of Feasible Doses.

    abstract:OBJECTIVE:The aims of this study were to compare 3 contrast agents and to define feasible doses for quantitative lung perfusion imaging using the dual-bolus approach in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Ten healthy volunteers (6 males, 4 females; mean age, 23.5 yea...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000224

    authors: Veldhoen S,Oechsner M,Fischer A,Weng AM,Kunz AS,Bley TA,Köstler H,Ritter CO

    更新日期:2016-03-01 00:00:00

  • Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.

    abstract:OBJECTIVE:The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan. MATERIALS AND METHODS:After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000186569.32408.95

    authors: White GW,Gibby WA,Tweedle MF

    更新日期:2006-03-01 00:00:00

  • Nonenhanced magnetic resonance angiography of the lower extremity vessels at 7 tesla: initial experience.

    abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of nonenhanced magnetic resonance angiography (MRA) of the lower extremities at 7 tesla (T). MATERIALS AND METHODS:Eight healthy volunteers were examined on a 7-T whole-body magnetic resonance system. For image acquisition, a custom-built 16-channel t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182839c2b

    authors: Fischer A,Maderwald S,Orzada S,Johst S,Schäfer LC,Ladd ME,Nassenstein K,Umutlu L,Lauenstein TC

    更新日期:2013-07-01 00:00:00

  • Educational objectives for diagnostic radiology residency training.

    abstract::A method of teaching radiology residents by identification of general and specific objectives to be accomplished during each time segment of the four-year training program has been developed. The objectives are incorporated into an educational contract that is signed by the resident and rotation director at the beginn...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198612000-00009

    authors: Howland WJ,Marler D,Bosshart D

    更新日期:1986-12-01 00:00:00

  • Low-dose transaxial tomography. An alternative to computed tomography for the evaluation of anteversion of the femur during childhood.

    abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Kushner DC,Cleveland RH,Ehrlich MG,Zaleske DJ,DeLuca SA,Herman TE,Webster EW

    更新日期:1985-12-01 00:00:00

  • Multishot targeted PROPELLER magnetic resonance imaging: description of the technique and initial applications.

    abstract:OBJECTIVES:To test the feasibility of combining inner-volume imaging (IVI) techniques with conventional multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) techniques for targeted-PROPELLER magnetic resonance imaging. MATERIALS AND METHODS:Perpendicular section-selective ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181a8b015

    authors: Deng J,Larson AC

    更新日期:2009-08-01 00:00:00

  • Ultrasound analysis of tongue, hyoid, and larynx activity during swallowing.

    abstract::Using real-time ultrasound, the motions of the tongue, hyoid bone, and larynx were monitored and timed during swallowing in ten normal subjects. A well-defined propulsive wave of the tongue was observed during swallowing a 5-cc water bolus. The body of the hyoid bone was identified on the ultrasound scan as a high ech...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198403000-00003

    authors: Shawker TH,Sonies B,Hall TE,Baum BF

    更新日期:1984-03-01 00:00:00

  • The spectrum of sonographic findings of fibroadenoma of the breast.

    abstract::There are a number of sonographic findings seen in fibroadenoma of the breast. In a retrospective study, we examined the biopsy results of 59 masses given the sonographic diagnosis of fibroadenoma. We also reviewed the sonograms of an additional 26 biopsy-proven fibroadenomas that were not diagnosed as such with ultra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198601000-00006

    authors: Jackson VP,Rothschild PA,Kreipke DL,Mail JT,Holden RW

    更新日期:1986-01-01 00:00:00

  • Sequential change of MR signal intensity of the brain after manganese administration in rabbits. Correlation with manganese concentration and histopathologic findings.

    abstract:RATIONALE AND OBJECTIVES:High signal intensity in the basal ganglia on T1-weighted MR imaging has been reported in chronic manganese (Mn) poisoning. However, the exact meaning of the high signal intensity remains unclear: does it result from Mn itself, secondary pathologic changes of the brain tissue, or both? The goal...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199906000-00001

    authors: Kim SH,Chang KH,Chi JG,Cheong HK,Kim JY,Kim YM,Han MH

    更新日期:1999-06-01 00:00:00

  • Feasibility of 3T dynamic contrast-enhanced magnetic resonance-guided biopsy in localizing local recurrence of prostate cancer after external beam radiation therapy.

    abstract:OBJECTIVES:The objective of this study was to assess the feasibility of the combination of magnetic resonance (MR)-guided biopsy (MRGB) and diagnostic 3T MR imaging in the localization of local recurrence of prostate cancer (PCa) after external beam radiation therapy (EBRT). MATERIALS AND METHODS:Twenty-four consecuti...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181c7bcda

    authors: Yakar D,Hambrock T,Huisman H,Hulsbergen-van de Kaa CA,van Lin E,Vergunst H,Hoeks CM,van Oort IM,Witjes JA,Barentsz JO,Fütterer JJ

    更新日期:2010-03-01 00:00:00

  • A silicone gel phantom suitable for multimodality imaging.

    abstract::A silicone gel phantom material is described. It can be molded into any shape and it can contain internal cavities. The material is selfsealing allowing the cavities to be filled with liquids. A simple geometric phantom consisting of a rectangular solid with a single internal spherical cavity was fabricated and imaged...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198702000-00013

    authors: Goldstein DC,Kundel HL,Daube-Witherspoon ME,Thibault LE,Goldstein EJ

    更新日期:1987-02-01 00:00:00

  • Binary nature and radiographic identifiability of craniosynostosis.

    abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199410000-00005

    authors: Pilgram TK,Vannier MW,Marsh JL,Kraemer BB,Rayne SC,Gado MH,Moran CJ,McAlister WH,Shackelford GD,Hardesty RA

    更新日期:1994-10-01 00:00:00

  • Terbutaline in diagnosis of interstitial fallopian tube obstruction.

    abstract::Effectiveness of terbutaline, a potent uterine muscle relaxant, for differentiation of temporary and anatomic interstitial fallopian tube obstruction (IFTO) at hysterosalpingography (HSG) was explored. In 43 IFTO evaluated, HSG after terbutaline showed patency in only one of 16 tubes in which IFTO was caused by spasm ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198803000-00010

    authors: Thurmond AS,Novy M,Rösch J

    更新日期:1988-03-01 00:00:00