Comparison of Power Versus Manual Injection in Bolus Shape and Image Quality on Contrast-Enhanced Magnetic Resonance Angiography: An Experimental Study in a Swine Model.


OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-tracking technique, and thoracic-abdominal time-resolved 4-dimensional [4D] MRA) were performed after power and manual injection of gadobutrol (0.1 mmol/kg) at 2 mL/s in 12 pigs (6 sets of power and manual injections for each type of CE-MRA). For the quantitative analysis, the signal-to-noise ratio was measured on ascending aorta, descending aorta, brachiocephalic trunk, common carotid artery, and external carotid artery on the 6 sets of head-neck 3D MRA, and on ascending aorta, descending aorta, brachiocephalic trunk, abdominal aorta, celiac trunk, and renal artery on the 6 sets of thoracic-abdominal 3D MRA. Bolus shapes were evaluated on the 6 sets each of test-bolus scans and 4D MRA. For the qualitative analysis, arterial enhancement, superimposition of nontargeted enhancement, and overall image quality were evaluated on 3D MRA. Visibility of bolus transition was assessed on 4D MRA. Intraindividual comparison between power and manual injection was made by paired t test, Wilcoxon rank sum test, and analysis of variance by ranks. RESULTS:Signal-to-noise ratio on 3D MRA was statistically higher with power injection than with manual injection (P < 0.001). Bolus shapes (test-bolus, 4D MRA) were represented by a characteristic standard bolus curve (sharp first-pass peak followed by a gentle recirculation peak) in all the 12 scans with power injection, but only in 1 of the 12 scans with manual injection. Standard deviations of time-to-peak enhancement were smaller in power injection than in manual injection. Qualitatively, although both injection methods achieved diagnostic quality on 3D MRA, power injection exhibited significantly higher image quality than manual injection (P = 0.001) due to significantly higher arterial enhancement (P = 0.031) and less superimposition of nontargeted enhancement (P = 0.001). Visibility of bolus transition on 4D MRA was significantly better with power injection than with manual injection (P = 0.031). CONCLUSIONS:Compared with manual injection, power injection provides more standardized bolus shapes and higher image quality due to higher arterial enhancement and less superimposition of nontargeted vessels.


Invest Radiol


Investigative radiology


Tsuboyama T,Jost G,Pietsch H,Tomiyama N




Has Abstract


2017-09-01 00:00:00












  • Evaluation of the integrity of the blood-brain barrier after meningeal trauma.

    abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Walker JD,Martin MA,Potts DG,Lemaire C,Templeton DM

    更新日期:1992-04-01 00:00:00

  • Fibroblast response to gadolinium: role for platelet-derived growth factor receptor.

    abstract:OBJECTIVE:The purpose of this study was to assess the effects of gadolinium (Gd3+), provided as gadolinium chloride, on fibroblast function. MATERIALS AND METHODS:Human dermal fibroblasts in monolayer culture and intact skin in organ culture were exposed to the lanthanide metal (1-20 μM). RESULTS:Increased proliferat...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Bhagavathula N,Dame MK,DaSilva M,Jenkins W,Aslam MN,Perone P,Varani J

    更新日期:2010-12-01 00:00:00

  • Evaluation of the prostate imaging reporting and data system for the detection of prostate cancer by the results of targeted biopsy of the prostate.

    abstract:PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Baur AD,Maxeiner A,Franiel T,Kilic E,Huppertz A,Schwenke C,Hamm B,Durmus T

    更新日期:2014-06-01 00:00:00

  • Selective catheterization for magnification angiography of internal spermatic and proper hepatic arteries in rabbits.

    abstract::A method is presented for selective catheterization and filming of the small internal spermatic and proper hepatic arteries in rabbits. The angiograms thus obtained afford clear delineation of the vessels and their branches and can enhance radiographic investigation of a variety of experimental disease models. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Young S,Hollenberg NK

    更新日期:1977-05-01 00:00:00

  • Evolution of the ablation region after magnetic resonance-guided high-intensity focused ultrasound ablation in a Vx2 tumor model.

    abstract:OBJECTIVES:Volumetric magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) is a completely noninvasive image-guided thermal ablation technique. Recently, there has been growing interest in the use of MR-HIFU for noninvasive ablation of malignant tumors. Of particular interest for noninvasive ablation...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Wijlemans JW,Deckers R,van den Bosch MA,Seinstra BA,van Stralen M,van Diest PJ,Moonen CT,Bartels LW

    更新日期:2013-06-01 00:00:00

  • Extravascular extravasation of radiographic contrast media. Effects of conventional and low-osmolar agents in the rat thigh.

    abstract::We compared the damage resulting from intradermal injection of four commonly used radiographic contrast media in laboratory rats. Sixty percent meglumine diatrizoate (Reno M 60) and ioxaglate (Hexabrix) produced significantly more ulceration and crusting on gross inspection and more necrosis, edema, and hemorrhage on ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cohan RH,Leder RA,Bolick D,Herzberg AJ,Hedlund LW,Wheeler CT,Helms MJ,Dunnick NR

    更新日期:1990-05-01 00:00:00

  • Expert learning system network for diagnosis of breast calcifications.

    abstract::Breast calcification diagnosis was studied by using clinical findings and computerized image processing of a mammogram in a network of trained expert learning systems (Outcome Advisor [OA]). The system was tested with records not used for training and performance was compared with radiologist. The network was 72% accu...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Patrick EA,Moskowitz M,Mansukhani VT,Gruenstein EI

    更新日期:1991-06-01 00:00:00

  • Renal blood oxygenation level-dependent imaging: contribution of R2 to R2* values.

    abstract:OBJECTIVES:The aim of this study was to assess the impact of oral water and intravenous furosemide challenges on blood oxygenation level-dependent magnetic resonance imaging measurements in the kidney and to examine the contribution of R2 (=1/T2) to changes in R2* (=1/T2*). MATERIALS AND METHODS:This Health Insurance ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Vivier PH,Storey P,Chandarana H,Yamamoto A,Tantillo K,Khan U,Zhang JL,Sigmund EE,Rusinek H,Babb JS,Bubenheim M,Lee VS

    更新日期:2013-07-01 00:00:00

  • Diffusivity- and T2 imaging at 3 Tesla for the detection of degenerative changes in human-excised tissue with high resolution: atherosclerotic arteries.

    abstract:RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Berg A,Sailer J,Rand T,Moser E

    更新日期:2003-07-01 00:00:00

  • Curved reconstructions versus three-dimensional surface rendering in the demonstration of cortical lesions in patients with extratemporal epilepsy.

    abstract:RATIONALE AND OBJECTIVES:To compare the visibility and localization of extratemporal cortical lesions in extratemporal epilepsy by using curved reconstruction (CR) and three-dimensional surface rendering (3D SR) of 3D-acquired MR images and to study the degree of confidence with which localizations are made, particular...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Meiners LC,Scheffers JM,De Kort GA,Burger H,Van Huffelen AC,Van Rijen PC,Van Veelen CW

    更新日期:2001-04-01 00:00:00

  • Nonenhanced magnetic resonance angiography of the lower extremity vessels at 7 tesla: initial experience.

    abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of nonenhanced magnetic resonance angiography (MRA) of the lower extremities at 7 tesla (T). MATERIALS AND METHODS:Eight healthy volunteers were examined on a 7-T whole-body magnetic resonance system. For image acquisition, a custom-built 16-channel t...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Fischer A,Maderwald S,Orzada S,Johst S,Schäfer LC,Ladd ME,Nassenstein K,Umutlu L,Lauenstein TC

    更新日期:2013-07-01 00:00:00

  • Saturation kinetics of iopanoate in dogs with an intact enterohepatic circulation. Before and after phenobarbital induction.

    abstract::Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Herzog RJ,Nelson JA,Staubus AE

    更新日期:1976-01-01 00:00:00

  • MR characterization of mild hyperthermia-induced gadodiamide release from thermosensitive liposomes in solid tumors.

    abstract:OBJECTIVES:Thermal dose in tumor tissue is a key factor for regional hyperthermia (HT) combined with chemotherapy and for drug delivery using thermosensitive liposomes (TSL). It influences therapy outcome, affects the accumulation of liposomes, and triggers the content release from TSL in the target tissue. For the dev...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Peller M,Schwerdt A,Hossann M,Reinl HM,Wang T,Sourbron S,Ogris M,Lindner LH

    更新日期:2008-12-01 00:00:00

  • Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the safety and pharmacokinetics of a newly developed MR contrast medium consisting of very small superparamagnetic iron oxide particles (VSOP) coated with citrate (VSOP-C184) in a clinical phase I trial. METHODS:A total of 18 healthy subjects received either VSOP-C184 (core diamete...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Taupitz M,Wagner S,Schnorr J,Kravec I,Pilgrimm H,Bergmann-Fritsch H,Hamm B

    更新日期:2004-07-01 00:00:00

  • Percutaneous radiofrequency ablation of hepatic colorectal metastases: technique, indications, results, and new promises.

    abstract::Surgical resection is the standard of care for colorectal metastases isolated to the liver. However, only 10-25% of the patients are eligible for resection because of extent and location of the disease in the liver or concurrent medical conditions. Image-guided radiofrequency (RF) ablation is a minimally invasive tech...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审


    authors: Lencioni R,Crocetti L,Cioni D,Della Pina C,Bartolozzi C

    更新日期:2004-11-01 00:00:00

  • Depiction of reperfused myocardial infarction using contrast-enhanced spin echo and gradient echo magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:The authors used gadolinium (Gd) chelate as a T1, T2, and T2* enhancing agent in reperfused myocardial infarction to compare the appearance of reperfused myocardial infarction on spin echo and gradient echo magnetic resonance (MR) sequences. METHODS:Rats (n = 28) were subjected to reperfused m...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Geschwind JF,Saeed M,Wendland MF,Higgins CB

    更新日期:1998-07-01 00:00:00

  • Effect of multiple intravenous injections of diatrizoate on iodine concentrations and osmolality. An experimental study in rabbits.

    abstract::Multiple intravenous injections of contrast media are used in radiology, but information regarding corresponding changes in the serum iodine concentrations and osmolality is lacking. We measured the changes in serum iodine concentration and serum osmolality in rabbits after a series of intravenous injections of contra...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Rubin DI,Kido DK,Morris TW,Fischer HW

    更新日期:1987-03-01 00:00:00

  • Evaluation of Gd-EOB-DTPA uptake in a perfused and isolated mouse liver model: correlation between magnetic resonance imaging and monochromatic quantitative computed tomography.

    abstract:OBJECTIVES:The aim of this work was to quantitatively evaluate the pharmacokinetic pattern of Gd-EOB-DTPA in a model of isolated and perfused mouse liver by using magnetic resonance imaging (MRI) and monochromatic quantitative computed tomography (MQCT). MATERIALS AND METHODS:For MQCT, perfusions were realized with th...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Segers J,Le Duc G,Laumonier C,Troprès I,Elst LV,Muller RN

    更新日期:2005-09-01 00:00:00

  • Patient choice and nonionic contrast media.

    abstract:RATIONALE AND OBJECTIVES:Because of the greatly increased cost of nonionic, low-osmolar contrast material, some practitioners reserve its use for patients at high risk for an adverse contrast reaction. The authors attempt to evaluate the proportion of low-risk outpatients--when offered a choice between the more expensi...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hopper KD,Matthews YL

    更新日期:1993-04-01 00:00:00

  • Development, chemistry, and physical properties of iopamidol and its analogues.

    abstract::A series of 5-hydroxyacylamino-2,4,6-triiodo-N,N'-hydroxy-alkyl-isophtalamides was prepared in order to study the structural requirements for high water solubility and low toxicity. Among the amides substituted by 2-hydroxyethyl; 2,3-dihydroxypropyl; 1,3-dihydroxypropyl-; and 1,1-dihydroxy-methyl-2-oxyethyl- groups, t...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Pitrè D,Felder E

    更新日期:1980-11-01 00:00:00

  • Phlebography. Survey and present state.

    abstract::Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of new nonionic contrast media is presented. ...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章


    authors: Enge I

    更新日期:1985-01-01 00:00:00

  • A qualitative investigation of turbulence in flow through a model abdominal aortic aneurysm.

    abstract:RATIONALE AND OBJECTIVES:As part of a general examination of the effect of blood flow patterns on the growth and risk of rupture of abdominal aortic aneurysms, the authors investigated the flow through an experimental model of a fusiform aneurysm. MATERIALS AND METHODS:Aneurysms were simulated in polyvinyl chloride tu...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Schrader T,Peattie RA,Bluth EI,Comstock CE

    更新日期:1992-07-01 00:00:00

  • Pediatric angiocardiography with iohexol.

    abstract::A nonionic contrast medium (iohexol) was evaluated for safety and efficacy in pediatric angiocardiography in this study of 15 patients, age 6 to 82 months. Patients carried a preliminary diagnosis of congenital heart disease. Subjects were injected with iohexol, 350 mg iodine/ml of solution with an average volume of 2...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Carlsson EC,Rudolph A,Stanger P,Teitel D,Weber W,Yoshida H

    更新日期:1985-01-01 00:00:00

  • Image fusion in dual energy computed tomography: effect on contrast enhancement, signal-to-noise ratio and image quality in computed tomography angiography.

    abstract:OBJECTIVE:The aim of this study was to evaluate the influence of different weighting factors on contrast enhancement, signal-to-noise ratio (SNR), and image quality in image fusion in dual energy computed tomography (DECT) angiography. MATERIAL AND METHODS:Fifteen patients underwent a CT angiography of the aorta with ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Behrendt FF,Schmidt B,Plumhans C,Keil S,Woodruff SG,Ackermann D,Mühlenbruch G,Flohr T,Günther RW,Mahnken AH

    更新日期:2009-01-01 00:00:00

  • Computed tomography-pathologic assessment of laser-induced necrosis in rat liver.

    abstract:RATIONALE AND OBJECTIVES:Interstitial laser photocoagulation (ILP) causes localized tissue necrosis. This study was performed to determine 1) whether the changes seen on computed tomography (CT) correspond to the necrosis pathologically, and 2) which CT technique best shows the necrosis. METHODS:Eighteen Wistar rats h...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Amin Z,Thurrell W,Spencer GM,Harries SA,Grant WE,Bown SG,Lees WR

    更新日期:1993-12-01 00:00:00

  • Hardcopy recording technologies for digitally formatted image data.

    abstract::The hardcopy recording technologies of video cameras, slow-scan (digital spot) recorders, and laser film printers are presented and compared. Slow-scan (digital spot) recorders offer a few advantages when compared with multiformat video cameras. But only laser film printers provide the high-quality hardcopy recordings...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Siegel EL,Bishop MD,Wetzel LH,Anderson WF,McMillan JH

    更新日期:1991-02-01 00:00:00

  • Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.

    abstract::The use of microbubble contrast agents for general tissue delineation and perfusion enjoys steady interest in ultrasound imaging. Microbubbles as contrast materials require a small dosage and show excellent detection sensitivity. Targeting ligands on the surface of microbubbles permit the selective accumulation of the...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审


    authors: Klibanov AL

    更新日期:2006-03-01 00:00:00

  • A silicone gel phantom suitable for multimodality imaging.

    abstract::A silicone gel phantom material is described. It can be molded into any shape and it can contain internal cavities. The material is selfsealing allowing the cavities to be filled with liquids. A simple geometric phantom consisting of a rectangular solid with a single internal spherical cavity was fabricated and imaged...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Goldstein DC,Kundel HL,Daube-Witherspoon ME,Thibault LE,Goldstein EJ

    更新日期:1987-02-01 00:00:00

  • Influences on the rate of absorption of the cholecystographic contrast medium iosumetic acid in man.

    abstract::Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Speck U,Clauss W,Blumenbach L,Albrecht A

    更新日期:1976-07-01 00:00:00

  • Vascular alterations in canine histiocytic ulcerative colitis.

    abstract::The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Lawson TL,Gomez JA,Margulis AR

    更新日期:1975-05-01 00:00:00