Feasibility of 3T dynamic contrast-enhanced magnetic resonance-guided biopsy in localizing local recurrence of prostate cancer after external beam radiation therapy.

Abstract:

OBJECTIVES:The objective of this study was to assess the feasibility of the combination of magnetic resonance (MR)-guided biopsy (MRGB) and diagnostic 3T MR imaging in the localization of local recurrence of prostate cancer (PCa) after external beam radiation therapy (EBRT). MATERIALS AND METHODS:Twenty-four consecutive men with biochemical failure suspected of local recurrence after initial EBRT were enrolled prospectively in this study. All patients underwent a diagnostic 3T MR examination of the prostate. T2-weighted and dynamic contrast-enhanced MR images (DCE-MRI) were acquired. Two radiologists evaluated the MR images in consensus for tumor suspicious regions (TSRs) for local recurrence. Subsequently, these TSRs were biopsied under MR-guidance and histopathologically evaluated for the presence of recurrent PCa. Descriptive statistical analysis was applied. RESULTS:Tissue sampling was successful in all patients and all TSRs. The positive predictive value on a per patient basis was 75% (15/20) and on a per TSR basis 68% (26/38). The median number of biopsies taken per patient was 3, and the duration of an MRGB session was 31 minutes. No intervention-related complications occurred. CONCLUSIONS:The combination of MRGB and diagnostic MR imaging of the prostate was a feasible technique to localize PCa recurrence after EBRT using a low number of cores in a clinically acceptable time.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Yakar D,Hambrock T,Huisman H,Hulsbergen-van de Kaa CA,van Lin E,Vergunst H,Hoeks CM,van Oort IM,Witjes JA,Barentsz JO,Fütterer JJ

doi

10.1097/RLI.0b013e3181c7bcda

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

121-5

issue

3

eissn

0020-9996

issn

1536-0210

journal_volume

45

pub_type

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