Large-tip-angle spin-echo imaging. Theory and applications.

Abstract:

RATIONALE AND OBJECTIVES:Tissue contrast phenomenology was investigated analytically and clinically for a class of magnetic resonance (MR) pulse sequences we call large-tip-angle (LTA) spin-echo (SE) imaging. In comparison to traditional SE sequences (denoted 90 degrees-180 degrees-echo), the LTA sequence is of the form alpha degrees-180 degrees-echo, where 90 degrees < alpha < 180 degrees. Theoretical analysis shows that appropriately designed LTA sequences can selectively boost the MR signal by 10%-150% in substances whose spin lattice (T1) relaxation values equal or exceed the sequence repetition time (TR). This unique contrast behavior potentially allows one to reduce TR (and hence imaging time) by 30% to 50% while maintaining constant T2-weighted contrast or contrast-to-noise within an image. METHODS:Preliminary clinical testing of LTA sequences was performed in 60 patients with a wide range of cranial, spinal, musculoskeletal, and abdominal pathologies. Large-tip-angle images (1,500/80/130 degrees) were blindly and prospectively compared to conventional (2,600/80/90 degrees) SE images. RESULTS:Principal diagnoses were concordant between the readers in all cases, although minor variances in detail features were noted in 6 (10%) of 60 cases. Large-tip-angle sequences revealed small cystic areas in two cerebral neoplasms and in a herniated disk which were not apparent on the standard SE images. However, the LTA images were rated to be "noisier" by visual assessment in 43 of 60 cases, the exception being for abdominal examinations, where respiratory and peristaltic artifacts were judged more severe on the standard SE sequences. CONCLUSIONS:Large-tip-angle SE imaging is an interesting technique capable of improving image contrast and signal from lesions with long T1 values when the sequence repetition time (TR) is short.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Elster AD,Provost TJ

doi

10.1097/00004424-199310000-00017

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

944-53

issue

10

eissn

0020-9996

issn

1536-0210

journal_volume

28

pub_type

杂志文章
  • Evaluation of intrarenal oxygenation at 3.0 T using 3-dimensional multiple gradient-recalled echo sequence.

    abstract:OBJECTIVE:The objective of this study was to validate quantitation of R2* and DeltaR2* measurements obtained with a 3-dimensional (3-D) multiple gradient-recalled echo (mGRE) sequence for evaluating intrarenal oxygenation in humans. MATERIALS AND METHODS:Validation was accomplished (1) by comparing R2* values with pre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000187166.43871.fb

    authors: Tumkur S,Vu A,Li L,Prasad PV

    更新日期:2006-02-01 00:00:00

  • Observation on the metabolism of iopanoyl (Telepaque) glucuronide in dogs treated with antibiotics.

    abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197805000-00011

    authors: Thoeni RF,Goldberg HI,Moss AA,Lin SK,Brito AC

    更新日期:1978-05-01 00:00:00

  • Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.

    abstract:OBJECTIVE:The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan. MATERIALS AND METHODS:After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000186569.32408.95

    authors: White GW,Gibby WA,Tweedle MF

    更新日期:2006-03-01 00:00:00

  • Dynamic contrast-enhanced computed tomography as a potential biomarker in patients with metastatic renal cell carcinoma: preliminary results from the Danish Renal Cancer Group Study-1.

    abstract:OBJECTIVES:The aim of this study was to explore the impact of dynamic contrast-enhanced (DCE) computer tomography (CT) as a biomarker in metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS:Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group and clear cell mRCC par...

    journal_title:Investigative radiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/RLI.0000000000000058

    authors: Mains JR,Donskov F,Pedersen EM,Madsen HH,Rasmussen F

    更新日期:2014-09-01 00:00:00

  • Evaluation of postprocessing dual-energy methods in quantitative computed tomography. Part 2. Practical aspects.

    abstract::Three facets of dual-energy quantitative computed tomography are studied: (1) the algorithm for postprocessing data (the methods of Cann, Laval-Jeantet et al, Goodsitt et al [two methods], and Nickoloff et al); (2) the influence of choice of tissue-equivalent materials for calibration; and (3) the difference between c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199008000-00003

    authors: van Kuijk C,Grashuis JL,Steenbeek JC,Schütte HE,Trouerbach WT

    更新日期:1990-08-01 00:00:00

  • Transverse ligament and its effect on meniscal motion. Correlation of kinematic MR imaging and anatomic sections.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the effect of the transverse ligament on translation of the menisci. METHODS:Six cadaveric knees were examined by MR imaging inside a positioning device before and after transecting the transverse ligament. The knees were examined at various positions: extension, 30 degrees of flex...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199909000-00002

    authors: Muhle C,Thompson WO,Sciulli R,Pedowitz R,Ahn JM,Yeh L,Clopton P,Haghighi P,Trudell DJ,Resnick D

    更新日期:1999-09-01 00:00:00

  • Hemodynamic effect of iodinated high-viscosity contrast medium in the rat kidney: a diffusion-weighted MRI feasibility study.

    abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200011000-00001

    authors: Laissy JP,Menegazzo D,Dumont E,Piekarski JD,Karila-Cohen P,Chillon S,Schouman-Claeys E

    更新日期:2000-11-01 00:00:00

  • A new class of contrast agents for magnetic resonance imaging based on selective reduction of water-T2 by chemical exchange.

    abstract::Compounds containing mobile protons can act as contrast agents by increasing the value of the term (1/12 - 1/11). The efficiency of this method is markedly pH- and field-dependent. There are many such compounds allowing a choice to be made based on the characteristics of the tissue or organ, magnetic field strength, a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198809001-00058

    authors: Aime S,Nano R,Grandi M

    更新日期:1988-09-01 00:00:00

  • Selective catheterization for magnification angiography of internal spermatic and proper hepatic arteries in rabbits.

    abstract::A method is presented for selective catheterization and filming of the small internal spermatic and proper hepatic arteries in rabbits. The angiograms thus obtained afford clear delineation of the vessels and their branches and can enhance radiographic investigation of a variety of experimental disease models. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197705000-00009

    authors: Young S,Hollenberg NK

    更新日期:1977-05-01 00:00:00

  • Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.

    abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Kim TH,Yang DH,Choi JW,Kim ST,Yoon JH,Shin JH,Seo JB,Gong GY,Lim TH

    更新日期:2005-01-01 00:00:00

  • Diagnostic performance of dark-blood T2-weighted CMR for evaluation of acute myocardial injury.

    abstract:OBJECTIVES:We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182718672

    authors: Srichai MB,Lim RP,Lath N,Babb J,Axel L,Kim D

    更新日期:2013-01-01 00:00:00

  • Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries.

    abstract::We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199103000-00010

    authors: Wilson MW,Webb RC,Marx MV,Meyer CR,Gallagher MA,Haarer SL,Buda AJ,Williams DM

    更新日期:1991-03-01 00:00:00

  • Expert learning system network for diagnosis of breast calcifications.

    abstract::Breast calcification diagnosis was studied by using clinical findings and computerized image processing of a mammogram in a network of trained expert learning systems (Outcome Advisor [OA]). The system was tested with records not used for training and performance was compared with radiologist. The network was 72% accu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199106000-00004

    authors: Patrick EA,Moskowitz M,Mansukhani VT,Gruenstein EI

    更新日期:1991-06-01 00:00:00

  • Evaluation of the dehydration-rehydration method for production of contrast-carrying liposomes.

    abstract::We measured the amounts of three types of radiographic contrast media (RCM) that could be entrapped in liposomes prepared by the dehydration-rehydration vesicle (DRV) technique. To make DRVs, one initially makes water-containing, small unilamellar vesicles, adds contrast media and lyophilizes the mixture. Upon rehydra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198802000-00009

    authors: Seltzer SE,Gregoriadis G,Dick R

    更新日期:1988-02-01 00:00:00

  • Hepatocellular carcinoma: correlation between vascular endothelial growth factor level and degree of enhancement by multiphase contrast-enhanced computed tomography.

    abstract:RATIONALE AND OBJECTIVES:To determine whether vascular endothelial growth factor (VEGF) is a histopathological factor influencing contrast enhancement of hepatocellular carcinoma (HCC) on computed tomography (CT). METHODS:Twenty-two nodular HCCs underwent multiphase helical CT and surgery. Tumor size, histological gra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200108000-00008

    authors: Kwak BK,Shim HJ,Park ES,Kim SA,Choi D,Lim HK,Park CK,Chung JW,Park JH

    更新日期:2001-08-01 00:00:00

  • Effect of a new nonionic contrast agent, ioxilan, on human erythrocytes and the hemostatic and serum complement pathways.

    abstract::A new nonionic contrast medium (CM), ioxilan, was compared with iohexol and iopamidol. Following incubation of whole heparinized blood with CM, the morphology and osmotic fragility of erythrocytes were studied, the former by transmission electron microscopy. Effects on platelets and hemocoagulation were determined by ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198809001-00032

    authors: Parvez Z,Patel NB

    更新日期:1988-09-01 00:00:00

  • Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

    abstract:RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200211000-00001

    authors: Schumann PA,Christiansen JP,Quigley RM,McCreery TP,Sweitzer RH,Unger EC,Lindner JR,Matsunaga TO

    更新日期:2002-11-01 00:00:00

  • Optimal injection protocol for CT evaluation during hepatic arterial infusion chemotherapy.

    abstract:OBJECTIVE:As an imaging modality for follow-up during continuous or repeated hepatic arterial infusion chemotherapy using a hepatic intra-arterial indwelling catheter, the usefulness of CT while infusing contrast through the indwelling catheter (reservoir port) was examined. METHODS:Using reservoir ports implanted in ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199912000-00003

    authors: Morimoto M,Satake M,Sekiguchi R,Haruno M,Moriyama N

    更新日期:1999-12-01 00:00:00

  • Improving CT-Based PET Attenuation Correction in the Vicinity of Metal Implants by an Iterative Metal Artifact Reduction Algorithm of CT Data and Its Comparison to Dual-Energy-Based Strategies: A Phantom Study.

    abstract:OBJECTIVE:The aim of this study was to evaluate the potential of iterative metal artifact reduction (IMAR) for the improvement of computed tomography (CT)-based position emission tomography (PET) attenuation correction in the vicinity of metal implants and compare it with dual-energy-based metal artifact reduction stra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000306

    authors: Schabel C,Gatidis S,Bongers M,Hüttig F,Bier G,Kupferschlaeger J,Bamberg F,la Fougère C,Nikolaou K,Pfannenberg C

    更新日期:2017-01-01 00:00:00

  • High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol.

    abstract:OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000227

    authors: Radbruch A,Weberling LD,Kieslich PJ,Hepp J,Kickingereder P,Wick W,Schlemmer HP,Bendszus M

    更新日期:2015-12-01 00:00:00

  • An overview of neck node sonography.

    abstract:RATIONALE AND OBJECTIVES:Gray scale and power Doppler sonography are commonly used to evaluate cervical lymph nodes. This study was undertaken to identify which of the features used in ultrasound of cervical lymph nodes is readily applicable in routine clinical practice. METHODS:Two hundred and eight-six patients diag...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200206000-00005

    authors: Ahuja A,Ying M

    更新日期:2002-06-01 00:00:00

  • Changes in complement and coagulation factors in a patient suffering a severe anaphylactoid reaction to injected contrast material: some considerations of pathogenesis.

    abstract::A patient, suffering a severe anaphylactoid reaction to contrast material injected for an intravenous pyelogram, developed a consumption coagulopathy and evidence of complement activation. Precontrast complement values suggested that the patient had been processing complement via the classical pathway, perhaps as a co...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198011001-00004

    authors: Lasser EC,Lang JH,Lyon SG,Hamblin AE

    更新日期:1980-11-01 00:00:00

  • CTA contrast enhancement of the aorta and pulmonary artery: the effect of saline chase injected at two different rates in a canine experimental model.

    abstract:OBJECTIVE:To investigate the effect of saline chase injected at 2 different rates on computed tomography (CT) angiography. MATERIALS AND METHODS:This study was approved by our institutional animal study committee. Three injection protocols were used; contrast injection (24 mL, 0.8 mL/s) without saline chase (protocol ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318032a9fe

    authors: Lee CH,Goo JM,Bae KT,Lee HJ,Kim KG,Chun EJ,Park CM,Im JG

    更新日期:2007-07-01 00:00:00

  • Longitudinal Computed Tomography Monitoring of Pelvic Bones in Patients With Breast Cancer Using Automated Bone Subtraction Software.

    abstract:OBJECTIVE:The aim of this study was to optimize computed tomography (CT) surveillance of skeletal metastases in patients with breast cancer through the use of osseous subtraction maps between baseline and follow-up examinations created by a novel software algorithm. The new postprocessing algorithm segments the origina...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000343

    authors: Horger M,Thaiss WM,Wiesinger B,Ditt H,Fritz J,Nikolaou K,Kloth C

    更新日期:2017-02-01 00:00:00

  • Pyrroxamide, a nonionic nitroxyl spin label contrast agent for magnetic resonance imaging. Mutagenesis and cell survival.

    abstract::Pyrroxamide [N-(1-hydroxymethyl-2,3-dihydroxypropyl)-2,2,5,5-tetramethyl pyrrolidine-1-oxyl-3-carboxyamide] is a newly tested nonionic monomeric nitroxyl compound with demonstrated effectiveness for MRI contrast enhancement at doses as low as 10(-3) M. Pyrroxamide and its hydroxylamine metabolic derivative were tested...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198808000-00013

    authors: Gordon DG,Brasch RC,Ogan MD,Deen D

    更新日期:1988-08-01 00:00:00

  • Whole-body diffusion-weighted imaging with apparent diffusion coefficient mapping for treatment response assessment in patients with diffuse large B-cell lymphoma: pilot study.

    abstract:OBJECTIVES:The aim of this pilot study was to assess post-treatment apparent diffusion coefficient (ADC) changes of diffuse large B-cell lymphoma lesions on respiratory-gated whole-body diffusion-weighted imaging (DWI), with integrated (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182087b03

    authors: Lin C,Itti E,Luciani A,Zegai B,Lin SJ,Kuhnowski F,Pigneur F,Gaillard I,Paone G,Meignan M,Haioun C,Rahmouni A

    更新日期:2011-05-01 00:00:00

  • Saturation kinetics of iopanoate in dogs with an intact enterohepatic circulation. Before and after phenobarbital induction.

    abstract::Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197601000-00007

    authors: Herzog RJ,Nelson JA,Staubus AE

    更新日期:1976-01-01 00:00:00

  • Design of an isolated pig heart preparation for positron emission tomography and magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:Validation of new positron emission tomography (PET) tracers or magnetic (MR) imaging contrast agents is based on isolated rodent heart preparations. The use of larger animals could provide a more direct validation using the devices used for humans. METHODS:An isolated pig heart preparation ha...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199711000-00010

    authors: Casali C,Obadia JF,Canet E,Bendjelid K,André-Fouët X,Revel D,Janier MF

    更新日期:1997-11-01 00:00:00

  • Response of tumors to therapy studied by 31P magnetic resonance spectroscopy.

    abstract::Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D2O, and in tumor adenosine triphosphate (ATP), measured by 31P ma...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198912000-00022

    authors: Karczmar GS,Meyerhoff DJ,Speder A,Valone F,Wilkinson M,Shine N,Boska MD,Weiner MW

    更新日期:1989-12-01 00:00:00

  • Three-dimensional cerebral contrast-enhanced magnetic resonance venography at 3.0 Tesla: initial results using highly accelerated parallel acquisition.

    abstract:OBJECTIVE:The objective of this study was to evaluate a high spatial resolution 3-dimensional (3D) contrast-enhanced magnetic resonance (CE-MR) venography protocol for evaluation of intracranial venous system using highly accelerated parallel imaging at 3.0 T. MATERIALS AND METHODS:Ten patients (4 male, 6 female; age,...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.rli.0000236992.21065.04

    authors: Nael K,Fenchel M,Salamon N,Duckwiler GR,Laub G,Finn JP,Villablanca JP

    更新日期:2006-10-01 00:00:00