Abstract:
:We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time- and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P less than .001): -5.2% with 10(-8) M serotonin, -15% with 10(-7) M, and -28% with 10(-6) M. Histologically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Wilson MW,Webb RC,Marx MV,Meyer CR,Gallagher MA,Haarer SL,Buda AJ,Williams DMdoi
10.1097/00004424-199103000-00010subject
Has Abstractpub_date
1991-03-01 00:00:00pages
248-53issue
3eissn
0020-9996issn
1536-0210journal_volume
26pub_type
杂志文章abstract::This article reviews the computer system hardware and software, applications programs, and computer network services that are available on microcomputers for use by the radiologist. The American College of Radiology Institute computer network is described, which is specifically designed to help the practicing radiolog...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198602000-00015
更新日期:1986-02-01 00:00:00
abstract:PURPOSE:To determine whether time-resolved magnetic resonance angiography (TR-MRA) with ultra-low-dose gadolinium chelate (1.5-3.0 mL) can reliably detect or rule out hemodynamically significant disease in the carotid-vertebral artery territory. MATERIALS AND METHODS:Hundred consecutive patients (62 women, 38 men, mea...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31819ca048
更新日期:2009-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors detect activation in the auditory cortex during cochlear electrical stimulation in deaf patients using functional magnetic resonance (MR) imaging. METHODS:Stimulating electrode was inserted gently under local anesthesia close to the round window membrane of the cochlea in seven coc...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199705000-00007
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate a high spatial resolution 3-dimensional (3D) contrast-enhanced magnetic resonance (CE-MR) venography protocol for evaluation of intracranial venous system using highly accelerated parallel imaging at 3.0 T. MATERIALS AND METHODS:Ten patients (4 male, 6 female; age,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/01.rli.0000236992.21065.04
更新日期:2006-10-01 00:00:00
abstract::Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of new nonionic contrast media is presented. ...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Paclitaxel added to angiographic contrast medium (CM) has been shown to inhibit restenosis in the porcine coronary overstretch model. This study determined early local tissue concentrations after the administration of different paclitaxel doses and preparations. MATERIALS AND METHODS:Fifteen p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000116125.96544.64
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS:A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000468
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000336
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the potential of quantitative assays of vascular characteristics based on dynamic contrast-enhanced magnetic resonance imaging (MRI) using a macromolecular contrast medium (MMCM) to search for and measure effects of dimethyl sulfoxide (DMSO) on cancer vasculature with microscopic correlations. M...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318164b71d
更新日期:2008-05-01 00:00:00
abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197805000-00011
更新日期:1978-05-01 00:00:00
abstract::The residency program at the University of Pennsylvania offers a 1-month fellowship for senior residents in medical student education. Instructional philosophy, methods, and content are discussed, observed, practiced, and evaluated. Close supervision and immediate feedback provide training particularly needed by futur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199006000-00028
更新日期:1990-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to develop and validate a computer-aided diagnosis (CAD) tool for automatic classification of pulmonary nodules seen on low-dose computed tomography into solid, part-solid, and non-solid. MATERIALS AND METHODS:Study lesions were randomly selected from 2 sites participating in t...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/RLI.0000000000000121
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000638
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To determine the reproducibility, accuracy, and predictors of accuracy of computed tomography (CT) angiography to detect and characterize coronary atherosclerotic plaque as compared with intravascular ultrasound. METHODS:Ten ex vivo human coronary arteries were imaged in a moving phantom by dual-source CT (col...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181e0a541
更新日期:2010-11-01 00:00:00
abstract::Maximum likelihood estimation, assuming a binormal model, has been used extensively to estimate the area under receiver operating characteristic (ROC) curves and thus provide an index of diagnostic accuracy for the comparison of two imaging systems. However, in some instances, a degenerate data set results in a fitted...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199007000-00016
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to validate quantitation of R2* and DeltaR2* measurements obtained with a 3-dimensional (3-D) multiple gradient-recalled echo (mGRE) sequence for evaluating intrarenal oxygenation in humans. MATERIALS AND METHODS:Validation was accomplished (1) by comparing R2* values with pre...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000187166.43871.fb
更新日期:2006-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS:In 10 experiments with mongrel dogs, the contrast agents were alternately injected ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199212000-00011
更新日期:1992-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the attenuation, size, and volume of the pericardial sinuses and recesses by using electrocardiographically triggered, noncontrast-enhanced electron beam tomography (EBT) and to consider its relation with sex, age, and heart volume. METHODS:Findings in 213 consecutive patients with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200006000-00004
更新日期:2000-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The ventral sacroiliac ligament (VSL), which bridges the sacroiliac (SI) joint anteriorly, has been described as an important stabilizing structure of the joint, but no data exist regarding its assessment with routine and advanced imaging methods. The authors determine the imaging appearance of...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199608000-00009
更新日期:1996-08-01 00:00:00
abstract::Advances in the field of magnetic resonance (MR) as it pertains to clinical diagnostic radiology are examined in this review on the basis of publications in Investigative Radiology over the past 2 years (2005-2006). The articles published during that timeframe are discussed, organizationally wise, by anatomic region w...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/01.rli.0000250461.03245.5c
更新日期:2006-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The author analyzes findings of consistency of rotator-cuff calcifications found at ultrasound (US)-guided needle treatment compared with findings of plain radiography, US, and computed tomography (CT). METHODS:Twenty patients had rotator-cuff calcifications (mean diameter, 1.5 cm; range, 1.1-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199605000-00010
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:Contrast-enhanced ultrasound imaging is increasingly being used in the clinic for assessment of tissue vascularity. The purpose of our study was to evaluate the effect of different contrast administration parameters on the in vivo ultrasound imaging signal in tumor-bearing mice using a maximum intensity pers...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181f9202d
更新日期:2011-03-01 00:00:00
abstract::The application of intravenous, intrathecal, and inhalation enhancement techniques to the CT evaluation of the nonhuman primate (Papio cynocephalus/anubis) is described. The falx cerebri cortical vasculature, vein of Galen, straight sinus and tentorium cerebelli were defined with intravenous enhancement. Intrathecal C...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00014
更新日期:1979-01-01 00:00:00
abstract::Using cardiac-gated fast acquisition with multiple excitation (FAME), time curves of the cerebral aqueduct signals were derived in 19 healthy volunteers and 14 patients. A mean curve of the normal subjects was determined during systole. A relatively stable point of time was found at 270 msec after the R-wave supposed ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198911000-00004
更新日期:1989-11-01 00:00:00
abstract::Virtually all receiver operating characteristic (ROC) studies of medical imaging methods have involved data collected on a discrete confidence-rating scale, though in principle ROC studies can be conducted with either discrete or continuous scales. Continuous scales provide potential advantages in medical applications...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199202000-00016
更新日期:1992-02-01 00:00:00
abstract::The density of trabecular bone in the os calcis has been measured in 321 subjects using a gamma ray scattering technique. In normal subjects it was shown that density could be predicted from body weight and age with a standard error of 5.6%. It was also shown that the dependence of density upon weight and age was the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198201000-00004
更新日期:1982-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199204000-00008
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVES:The purpose of our study was to assess the potential for radiation dose reduction in digital postinterventional digital mammograms after marker placement. MATERIALS AND METHODS:One hundred consecutive cases of marker placement (hook-wire localization or postbiopsy clip marker placement), with 200 full-field...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000163743.63063.9f
更新日期:2005-06-01 00:00:00
abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-197811000-00008
更新日期:1978-11-01 00:00:00
abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000261937.77365.6a
更新日期:2007-06-01 00:00:00