A new class of contrast agents for magnetic resonance imaging based on selective reduction of water-T2 by chemical exchange.

abstract：RATIONALE AND OBJECTIVES:Our purpose was to validate contrast-enhanced computed tomography (CECT)-derived quantitative measures of perfusion and permeability against gold standard techniques of fluorescent microspheres and Evan's Blue dye, respectively. MATERIALS AND METHODS:Normal and tumor-bearing (R3230AC) Fischer ...

journal_title：Investigative radiology

authors： Pollard RE,Garcia TC,Stieger SM,Ferrara KW,Sadlowski AR,Wisner ER

更新日期：2004-06-01 00:00:00

abstract：:Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...

journal_title：Investigative radiology

authors： Siegle RL,Lieberman P,Rice MC

更新日期：1983-07-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Tissue contrast phenomenology was investigated analytically and clinically for a class of magnetic resonance (MR) pulse sequences we call large-tip-angle (LTA) spin-echo (SE) imaging. In comparison to traditional SE sequences (denoted 90 degrees-180 degrees-echo), the LTA sequence is of the for...

journal_title：Investigative radiology

authors： Elster AD,Provost TJ

更新日期：1993-10-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:To assess the influence of injection rates and volumes on the arrival time of contrast material (CM) in the common carotid artery, the jugular vein and the resulting arterial-venous transit time. Additionally the relationship between injection parameters and the extent of a CM plateau was evalu...

journal_title：Investigative radiology

authors： Herold T,Paetzel C,Völk M,Bachthaler M,Zorger N,Feuerbach S,Strotzer M,Lenhart M

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual source computed tomography (CT) for the qualitative and quantitative assessment of myocardial blood flow (MBF) compared with stress perfusion and viability magnetic resonance imaging (MRI). ...

journal_title：Investigative radiology

authors： Bastarrika G,Ramos-Duran L,Rosenblum MA,Kang DK,Rowe GW,Schoepf UJ

更新日期：2010-06-01 00:00:00

abstract：:We present a new method for evaluating in vivo changes in bone mineralization in the peripheral skeleton, using computed tomography (CT). A set of bone mineralization indices are generated from numerous CT images of the patient's distal radius. The cross-sectional anatomy displayed by the CT scan allows for separate e...

journal_title：Investigative radiology

authors： Orphanoudakis SC,Jensen PS,Rauschkolb EN,Lang R,Rasmussen H

更新日期：1979-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Bolus injection of iodinated contrast media has been observed to alter myocardial mechanical function, but the consequences on cellular metabolism are poorly documented. Modifications of metabolic parameters (intracellular pH as well as adenosine triphosphate [ATP], phosphocreatine, and inorgan...

journal_title：Investigative radiology

authors： Goossens A,Vander Elst L,Van Haverbeke Y,Muller RN

更新日期：1995-01-01 00:00:00

abstract：:Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...

journal_title：Investigative radiology

authors： Clark RL,Friedman M,Kwock L,Zaremba J

更新日期：1983-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors assessed whether a non-sleep-deprived, second-year diagnostic radiology resident assigned to an after-hours "night stalker" emergency radiology (ER) rotation in an urban university hospital has a measurable impact on the number and clinical significance of "missed" radiologic findin...

journal_title：Investigative radiology

authors： Mann FA,Danz PL

更新日期：1993-01-01 00:00:00

abstract：:We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz...

journal_title：Investigative radiology

authors： Wilson MW,Webb RC,Marx MV,Meyer CR,Gallagher MA,Haarer SL,Buda AJ,Williams DM

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to develop and validate a computer-aided diagnosis (CAD) tool for automatic classification of pulmonary nodules seen on low-dose computed tomography into solid, part-solid, and non-solid. MATERIALS AND METHODS:Study lesions were randomly selected from 2 sites participating in t...

journal_title：Investigative radiology

authors： Jacobs C,van Rikxoort EM,Scholten ET,de Jong PA,Prokop M,Schaefer-Prokop C,van Ginneken B

更新日期：2015-03-01 00:00:00

abstract：:A series of 5-hydroxyacylamino-2,4,6-triiodo-N,N'-hydroxy-alkyl-isophtalamides was prepared in order to study the structural requirements for high water solubility and low toxicity. Among the amides substituted by 2-hydroxyethyl; 2,3-dihydroxypropyl; 1,3-dihydroxypropyl-; and 1,1-dihydroxy-methyl-2-oxyethyl- groups, t...

journal_title：Investigative radiology

authors： Pitrè D,Felder E

更新日期：1980-11-01 00:00:00

abstract：:Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglum...

journal_title：Investigative radiology

authors： Kim SH,Park JH,Kim YI,Kim CW,Han MC

更新日期：1990-06-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...

journal_title：Investigative radiology

authors： Walker JD,Martin MA,Potts DG,Lemaire C,Templeton DM

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVES:The incidence of coronary artery disease has been shown to be greater in patients with calcific deposits than in those without. It has been suggested that the pattern of distribution of coronary calcific deposits within coronary arteries is of greater predictive value for acute coronary events than the overa...

journal_title：Investigative radiology

authors： Wilner WT,Mazraeshahi RM,Aboshady I,Bodmann BG,Papadakis M,Kouri D,Conyers JL,Cherukuri P,Vela D,Gladish G,Gavish L,Cody DD,Frazier L,Lukovenkov S,Madjid M,Zarrabi A,Ahmed A,Willerson JT,Casscells SW,Gertz SD

更新日期：2007-11-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The basic characteristics of BR1, a novel echo contrast agent based on stabilized sulfur hexafluoride (SF6) microbubbles have been evaluated. METHODS:The authors determined the physicochemical properties (bubble concentration, bubble size distribution, resistance to pressure, and stability) an...

journal_title：Investigative radiology

authors： Schneider M,Arditi M,Barrau MB,Brochot J,Broillet A,Ventrone R,Yan F

更新日期：1995-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors synthesized and tested a novel hydrogel system proposed for use in extra- and intravascular radiologic interventions, such as chemoembolizations and embolizations, and as a vehicle for sustained drug release. MATERIALS:The material was specifically designed to meet the prerequisite...

journal_title：Investigative radiology

authors： Weissleder R,Bogdanov A,Frank H,Nossiff N,Bogdanova A,Schaffer BK,Brady T,Wittenberg J

更新日期：1993-12-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Interstitial laser photocoagulation (ILP) causes localized tissue necrosis. This study was performed to determine 1) whether the changes seen on computed tomography (CT) correspond to the necrosis pathologically, and 2) which CT technique best shows the necrosis. METHODS:Eighteen Wistar rats h...

journal_title：Investigative radiology

authors： Amin Z,Thurrell W,Spencer GM,Harries SA,Grant WE,Bown SG,Lees WR

更新日期：1993-12-01 00:00:00

abstract：:The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...

journal_title：Investigative radiology

authors： Barth KH,Lutz RJ,Kremers PW,Miller DL

更新日期：1988-07-01 00:00:00

abstract：:Electromagnetic flow measurement study was performed in 20 anesthetized dogs to evaluate the effect of selective celiac infusion of vasopressin on the hepatic arterial vasculature. Teh hepatic arterial flow showed a biphasic response with an initial decrease followed by a substantial increase in spite of a continued ...

journal_title：Investigative radiology

authors： Barr JW,Lakin RC,Rösch J

更新日期：1975-05-01 00:00:00

abstract：PURPOSE:To prospectively determine the accuracy of 1.5 Tesla (T) and 3 T magnetic resonance angiography (MRA) versus digital subtraction angiography (DSA) in the depiction of infrageniculate arteries in patients with symptomatic peripheral arterial disease. PATIENTS AND METHODS:A prospective 1.5 T, 3 T MRA, and DSA co...

journal_title：Investigative radiology

authors： Diehm N,Kickuth R,Baumgartner I,Srivastav SK,Gretener S,Husmann MJ,Jaccard Y,Do do D,Triller J,Bonel HM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-t...

journal_title：Investigative radiology

authors： Tsuboyama T,Jost G,Pietsch H,Tomiyama N

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:We sought to develop a robotic system for computed tomography (CT)-guided biopsy to validate the feasibility, accuracy, and efficacy of the system using phantom tests. MATERIALS AND METHODS:Ten peas (mean diameter 9.9+/-0.4 mm) embedded within a gel phantom were selected for biopsy. Once the best access was de...

journal_title：Investigative radiology

authors： Kettenbach J,Kronreif G,Figl M,Fürst M,Birkfellner W,Hanel R,Ptacek W,Bergmann H

更新日期：2005-04-01 00:00:00

abstract：:Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...

journal_title：Investigative radiology

authors： Jabour BA,Ralls PW,Tang WW,Boswell WD Jr,Colletti PM,Feinstein EI,Massry SG

更新日期：1987-09-01 00:00:00

abstract：:Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...

journal_title：Investigative radiology

authors： Speck U,Clauss W,Blumenbach L,Albrecht A

更新日期：1976-07-01 00:00:00

abstract：OBJECTIVE:As an imaging modality for follow-up during continuous or repeated hepatic arterial infusion chemotherapy using a hepatic intra-arterial indwelling catheter, the usefulness of CT while infusing contrast through the indwelling catheter (reservoir port) was examined. METHODS:Using reservoir ports implanted in ...

journal_title：Investigative radiology

authors： Morimoto M,Satake M,Sekiguchi R,Haruno M,Moriyama N

更新日期：1999-12-01 00:00:00

abstract：:The effect of intravenous urography (IVU) on the excretion rate and precipitation of Tamm-Horsfall glycoprotein (THG) has been evaluated in 19 patients. Urine samples were collected immediately before the administration of contrast medium (U1) and then during the period of the excretion urogram (U2). The urinary THG: ...

journal_title：Investigative radiology

authors： Dawnay AB,Thornley C,Nockler I,Webb JA,Cattell WR

更新日期：1985-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The authors investigate whether a modified gadolinium (Gd)-DTPA formulation can be aerosolized and used as a contrast agent for magnetic resonance (MR) ventilation imaging of the lungs. METHODS:Gadolinium-DTPA (gadopentetate dimeglumine, Schering AG, Berlin, Germany, 100 mmol Gd/L) was modifie...

journal_title：Investigative radiology

authors： Misselwitz B,Mühler A,Heinzelmann I,Böck JC,Weinmann HJ

更新日期：1997-12-01 00:00:00

abstract：:The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...

journal_title：Investigative radiology

authors： Kuribayashi S,Garnic JD,Abrams HL

更新日期：1982-11-01 00:00:00

abstract：:Sixteen observers averaging 7.4 years experience in interpreting radiology images and 16 observers without radiology training were tested for their ability to detect low-contrast signals in structured noise backgrounds using a digital display system. No significant difference in true positives, false positives, time t...

journal_title：Investigative radiology

authors： Rackow PL,Spitzer VM,Hendee WR

更新日期：1987-04-01 00:00:00