Effect of additional cations on the twitching reaction to intracarotid, nonionic contrast media in rabbits.

Abstract:

:Previous investigations in this laboratory have confirmed the observation of facial muscle twitching during intracarotid injections of nonionic contrast media (CM) in rabbits. The reaction appears to be a locally mediated effect. To further investigate this reaction, cortical electroencephalogram (EEG) and facial electromyogram (EMG) recordings were made from rabbits receiving selective internal carotid artery (ICA) and external carotid artery (ECA) injections of CM. The effects of iopromide and iohexol were compared with and without the addition of sodium (Na) and calcium (Ca) ions at different concentrations. External carotid injections of iopromide also were performed in some animals paralyzed with D-tubocurarine to exclude the possibility that the reaction is due to an effect on peripheral nerves. The addition of between 5 and 20 mM Ca ions to both CM prevented the reaction but while the addition of Na ions (up to 150 mM) to iopromide had some preventative effect, it did not totally abolish the reaction. In those animals paralyzed with D-tubocurarine, the reaction to iopromide, as observed and recorded by EMG, was the same as that occurring in nonparalyzed animals. This finding is consistent with this reaction being independent of the peripheral nervous system.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Whisson CC,Evill CA,Sage MR,Wilson AJ

doi

10.1097/00004424-199009000-00010

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

1004-9

issue

9

eissn

0020-9996

issn

1536-0210

journal_volume

25

pub_type

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