Abstract:
:Previous investigations in this laboratory have confirmed the observation of facial muscle twitching during intracarotid injections of nonionic contrast media (CM) in rabbits. The reaction appears to be a locally mediated effect. To further investigate this reaction, cortical electroencephalogram (EEG) and facial electromyogram (EMG) recordings were made from rabbits receiving selective internal carotid artery (ICA) and external carotid artery (ECA) injections of CM. The effects of iopromide and iohexol were compared with and without the addition of sodium (Na) and calcium (Ca) ions at different concentrations. External carotid injections of iopromide also were performed in some animals paralyzed with D-tubocurarine to exclude the possibility that the reaction is due to an effect on peripheral nerves. The addition of between 5 and 20 mM Ca ions to both CM prevented the reaction but while the addition of Na ions (up to 150 mM) to iopromide had some preventative effect, it did not totally abolish the reaction. In those animals paralyzed with D-tubocurarine, the reaction to iopromide, as observed and recorded by EMG, was the same as that occurring in nonparalyzed animals. This finding is consistent with this reaction being independent of the peripheral nervous system.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Whisson CC,Evill CA,Sage MR,Wilson AJdoi
10.1097/00004424-199009000-00010subject
Has Abstractpub_date
1990-09-01 00:00:00pages
1004-9issue
9eissn
0020-9996issn
1536-0210journal_volume
25pub_type
杂志文章abstract::The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000507
更新日期:2018-10-01 00:00:00
abstract::Polylysine covalently linked to moieties of gadopentetate (Gd-DTPA), for use as a macromolecular blood pool marker for contrast material-enhanced magnetic resonance imaging (MRI), was characterized by means of physicochemical measurements and pharmacokinetics in rats and rabbits and compared with Gd-DTPA. Gd-DTPA-poly...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199111000-00008
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVES:Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. MATERIAL AND METHODS:After induction of hepatic ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318155aa2e
更新日期:2008-02-01 00:00:00
abstract::We have examined the metabolic behavior of several triiodobenzoic acid derivatives because of the observed mutagenicity and cytotoxicity of 3-amino-5-acetamido-2,4,6-triiodobenzoate (I) and 3,5-diamino-2,4,6-triiodobenzoate (II). Measurements were facilitated using iodine-131 (131I)-labeled compounds. Drug retention i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract::In order to measure the accuracy of a diagnostic imaging technique, the correctness of each observer decision must be determined. This is often difficult in clinical cases, and various strategies are frequently used to approximate the truth. Experiments using chest radiographs as an example are reported to show the pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198303000-00018
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000064
更新日期:2014-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare trabecular bone structure measures obtained in magnetic resonance images of the distal radius and the calcaneus as well as computed tomographic images of the spine versus bone mineral density (BMD) of the spine and the calcaneus in the prediction of osteoporotic spine fracture status...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000129154.50654.4e
更新日期:2004-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance imaging (MRI) techniques seem to be very promising for 3D dosimetry studies, but long imaging acquisition time limits their use. A new fast T1 mapping protocol, easy to implement on a conventional MR imager, has been used to determine dose distributions on Fricke gels. METHO...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199903000-00014
更新日期:1999-03-01 00:00:00
abstract::The application of intravenous, intrathecal, and inhalation enhancement techniques to the CT evaluation of the nonhuman primate (Papio cynocephalus/anubis) is described. The falx cerebri cortical vasculature, vein of Galen, straight sinus and tentorium cerebelli were defined with intravenous enhancement. Intrathecal C...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00014
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to optimize computed tomography (CT) surveillance of skeletal metastases in patients with breast cancer through the use of osseous subtraction maps between baseline and follow-up examinations created by a novel software algorithm. The new postprocessing algorithm segments the origina...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000343
更新日期:2017-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The objective is to assess the diagnostic accuracy and interobserver variability of multiphase 3D gadolinium-enhanced magnetic resonance angiography (3D-Gd-MRA) for assessment of abdominal and pelvic vascular disease. METHODS:In 41 patients from two different institutions multiphase 3D-Gd-MRA ...
journal_title:Investigative radiology
pub_type: 杂志文章,多中心研究
doi:10.1097/00004424-200201000-00005
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000183054.43131.a8
更新日期:2005-11-01 00:00:00
abstract::Chest radiographs are commonly obtained to assess children for bronchiolitis, both to corroborate the diagnosis and to exclude other diagnostic possibilities. Their utility in this setting has not previously been examined. Using a blinded, randomized study design, we examined the interobserver and intraobserver variat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199102000-00004
更新日期:1991-02-01 00:00:00
abstract::The cerebrovascular toxicity of three water-soluble contrast agents with a low hypertonicity (metrizamide, ioxaglate, iopamidol) was tested. Blood-brain barrier damage after carotid injection was assessed using 32P autoradiography and fluorescent microscopy after Evans blue staining. The damage to carotid endothelium ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00058
更新日期:1980-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors determine the value of contrast-enhanced, three-dimensional (3D) magnetic resonance angiography (MRA) in the assessment of the renal arteries in comparison with conventional arteriography (CA). METHODS:One hundred three patients (71 m, 32 f) were evaluated with both CA and 3D MRA. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199809000-00021
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31805f2682
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effects of gadolinium (Gd3+), provided as gadolinium chloride, on fibroblast function. MATERIALS AND METHODS:Human dermal fibroblasts in monolayer culture and intact skin in organ culture were exposed to the lanthanide metal (1-20 μM). RESULTS:Increased proliferat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181e943d2
更新日期:2010-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this article, the unique adaptations of MRM required in the study of caro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199409000-00004
更新日期:1994-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Bolus injection of iodinated contrast media has been observed to alter myocardial mechanical function, but the consequences on cellular metabolism are poorly documented. Modifications of metabolic parameters (intracellular pH as well as adenosine triphosphate [ATP], phosphocreatine, and inorgan...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199501000-00001
更新日期:1995-01-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic performance of 1.0-M gadobutrol-enhanced, 3-dimensional (3D), dynamic MR images with 3D-MR cholangiography (MRC) in the preoperative evaluation of bile duct cancer staging and resectability. MATERIALS AND METHODS:Our institutional review board approved this retrospective study. Sixty...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181d2eeb1
更新日期:2010-04-01 00:00:00
abstract::This paper presents a microcomputer-based technique that accurately quantifies volumes from computed tomographic (CT) scans of irregularly shaped objects as well as displaying 3-D reconstructions. The method uses standard CT film, allowing analysis of previous or outside CT studies. The planimetry method showed less t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198812000-00001
更新日期:1988-12-01 00:00:00
abstract::Frequency spectral analysis of cardiac wall motion as calculated from the recorded video kymogram are demonstrated. Characteristic harmonics following the fundamental frequency of the cardiac rate have been demonstrated to have an alternating sequential energy distribution as measured from the free margin of the left ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197503000-00005
更新日期:1975-03-01 00:00:00
abstract::Gelatin encapsulated nitrogen microbubbles were effective ultrasonic contrast agents in in vitro phantom and in vivo rabbit V2 carcinoma studies. Intra-arterial injection of 80-micrometer gelatin encapsulated nitrogen microbubbles appeared to improve tumor visualization by rim enhancement, which persisted for several ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198005000-00013
更新日期:1980-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199704000-00008
更新日期:1997-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors determine the relative effect of soft-tissue compartments, body fat (percent [%Bfat] and weight [Bfat kg]) and fat-free mass (FFM kg), on measurements of ultrasound bone velocity (UBV m/second). METHODS:The authors measured UBV in proximal phalanxes and body fat and fat-free mass b...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199710000-00005
更新日期:1997-10-01 00:00:00
abstract::Arterial occlusion by direct-current transcatheter electrocoagulation (TCEC) has been developed experimentally and used successfully in clinical situations. The major shortcoming of the technique has been the lengthy time necessary for occlusion of larger arteries. In the present study we attempted to decrease the tim...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198203000-00011
更新日期:1982-03-01 00:00:00
abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00004
更新日期:1979-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Measurements of segmental contraction of the left ventricle by standard magnetic resonance imaging (MRI) and two-dimensional echocardiography involve the comparison of diastolic and systolic time frames acquired from the same imaging plane in space. As the cone-shaped left ventricle shortens al...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199209000-00004
更新日期:1992-09-01 00:00:00