Abstract:
RATIONALE AND OBJECTIVES:To measure the hepatic uptake and biliary elimination kinetics of gadolinium (Gd)-EOB-DTPA in dogs. METHOD:Two groups of four beagles each were anesthetized and given an intravenous bolus of 25 mumol/kg or 250 mumol/kg of Gd-EOB-DTPA. Blood, hepatic bile, and urine were collected over 140 minutes, and liver samples were obtained immediately after the dogs were killed. Conventional T1-weighted spin echo sequences of the liver were performed on a 1.5-Tesla (T) magnetic resonance imager during sampling. A ninth beagle received a bolus of 25 mumol/kg followed 140 minutes later with a bolus of 250 mumol/kg of Gd-EOB-DTPA. Wedge liver biopsies were obtained for Gd estimation at various times after dosing, and Gd concentration was measured by inductively coupled plasma atomic emission spectroscopy. RESULTS:The plasma concentration of Gd-EOB-DTPA decreased in a biexponential manner with half-lives of approximately 4 minutes and 60 minutes for the distribution and elimination phase independent of the dose given. Gadolinium bile concentration reached peak values between 80 and 140 minutes: 6.3 +/- 1.6 mmol/L for the low dose (LD) and 11.6 +/- mmol/L for the high dose (HD). Bile Gd output was 62.0 +/- 8.8 (LD) and 78.3 +/- 30.2 (HD) nmol/minute-kg 50 to 80 minutes after injection. Gadolinium-EOB-DTPA was excreted by the biliary route to 24.8 +/- 2.6 (LD) and 3.6 +/- 1.2 (HD) percent of the dose within 140 minutes. Liver Gd concentration was 0.43 +/- 0.14 (LD) and 4.3 +/- 0.5 (HD) mmol/kg liver tissue at the conclusion of the studies. Calculated concentrations in the hepatocyte were 60 (LD) and 15 (HD) times higher than in plasma at 25 minutes after dosing. Whereas the low dose exhibited excellent contrast enhancement for the whole period, the high dose displayed a biphasic signal enhancement with a decreasing signal caused by the too-high hepatic gadolinium accumulation. CONCLUSIONS:Transport of the Gd-EOB-DTPA into the hepatocyte exceeded elimination from hepatocyte to bile. The high dose defined a biliary transport maximum for Gd-EOB-DTPA of 78.3 +/- 30.2 nmol/minute-kg. The liver accumulation results from fast transport into the hepatocyte and rate-limited slower transport from hepatocyte to bile. The accumulation occurs against a strong concentration gradient, suggesting energy-dependent active transport into the hepatocyte.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Benness G,Khangure M,Morris I,Warwick A,Burrows P,Vogler H,Weinmann HJdoi
10.1097/00004424-199604000-00005subject
Has Abstractpub_date
1996-04-01 00:00:00pages
211-7issue
4eissn
0020-9996issn
1536-0210journal_volume
31pub_type
杂志文章abstract:OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31822311a9
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on insp...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181690111
更新日期:2008-06-01 00:00:00
abstract::Using a 1.5 T magnetic resonance imaging (MRI) system, cine phase-contrast and magnitude images were obtained in three phantoms that simulated different anatomic configurations of aortic dissection. The dissection phantoms were made of compliant materials, and pulsatile flow was used in all experiments. Phantoms diffe...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199112000-00007
更新日期:1991-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Ureteric jet index (UJI), a newly developed technique derived from color Doppler ultrasonography, may hold promise in evaluating renal function because of its ability to evaluate individual renal function and the use of nonionizing radiation. To assess the usefulness of UJI, the authors in this...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199908000-00001
更新日期:1999-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions. MATERIALS AND METHODS:A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199610000-00003
更新日期:1996-10-01 00:00:00
abstract::In vivo and in vitro studies have shown that areas of myocardial infarctions can be delineated on CT scans after intravenous administration of iodinated contrast material to dogs with experimental myocardial infarctions. Within the first minute after intravenous administration of contrast material (initial myocardial ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00039
更新日期:1980-11-01 00:00:00
abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199304001-00014
更新日期:1993-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000436
更新日期:2018-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors detect activation in the auditory cortex during cochlear electrical stimulation in deaf patients using functional magnetic resonance (MR) imaging. METHODS:Stimulating electrode was inserted gently under local anesthesia close to the round window membrane of the cochlea in seven coc...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199705000-00007
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine if voxel-based histogram analysis of intravoxel incoherent motion imaging (IVIM) parameters can differentiate various subtypes of renal tumors, including benign and malignant lesions. SUBJECTS AND METHODS:A total of 44 patients with renal tumors who underwent surgery a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000111
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000431
更新日期:2018-04-01 00:00:00
abstract::Gallbladder sclerotherapy after permanent cystic duct occlusion, to prevent gallstone recurrence in nonsurgical gallstone therapy, is at least a two-stage procedure. A balloon catheter was developed to perform gallbladder sclerotherapy with only temporary occlusion of the cystic duct, and the efficacy and safety of th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199109000-00005
更新日期:1991-09-01 00:00:00
abstract:PURPOSE:To evaluate the dependency of tumor contrast enhancement (CE) in regard to protein-binding properties of contrast agents, using 4 different agents with a wide range of protein-binding capacities in a standardized rat brain glioma model. MATERIAL AND METHODS:Sixteen rats with implanted brain gliomas were evalua...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318191a334
更新日期:2009-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To summarize the chemical synthesis, physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P743, a new macromolecular iodinated contrast medium. METHODS:The synthesis and molecular modeling of the iodinated macromolecule P743 are described. The pharmacokineti...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200101000-00006
更新日期:2001-01-01 00:00:00
abstract::Recent publications of the magnetic resonance safety profile of neurostimulators, cardiac pacemakers, and other implanted devices imply that these devices are no longer a contraindication for magnetic resonance imaging. It is very promising that patients who have these implanted devices may in the future no longer be ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000185898.59140.91
更新日期:2005-12-01 00:00:00
abstract::We evaluated the incidence of ventricular fibrillation with low-osmolality contrast media by right coronary arteriography in eleven adult mongrel dogs. Following insertion of the catheter into the right coronary artery, a test solution was infused for 25 seconds (total 11 mL) or until fibrillation occurred. The test s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198904000-00008
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVES:To test the feasibility of combining inner-volume imaging (IVI) techniques with conventional multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) techniques for targeted-PROPELLER magnetic resonance imaging. MATERIALS AND METHODS:Perpendicular section-selective ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181a8b015
更新日期:2009-08-01 00:00:00
abstract:RATIONAL AND OBJECTIVES:Magnetic resonance (MR) scan technique and lesion detectability were evaluated using a newly developed spinal abscess model in the New Zealand White rabbit. METHODS:To create the lesion, an epidural needle was inserted under fluoroscopic guidance in the lumbar region and advanced to penetrate t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199804000-00008
更新日期:1998-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors differentiate acute tubular necrosis from transplant rejection in patients with delayed kidney graft function using gadolinium (Gd)-DTPA enhanced magnetic resonance (MR) imaging. METHODS:Twenty-four patients after renal transplantation (10 with normal graft function, 14 with delaye...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-199606000-00009
更新日期:1996-06-01 00:00:00
abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198712000-00008
更新日期:1987-12-01 00:00:00
abstract::Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00018
更新日期:1983-07-01 00:00:00
abstract::Erythrocytes at various concentrations were examined with a sensitive A-mode ultrasonic scanner; simultaneous measurements were made under light microscopic control. Individual erythrocytes caused weak (about 1 dB) echoes while erythrocyte aggregates (ten to 100 cells) produced stronger echoes (up to 15 dB), grossly p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198508000-00014
更新日期:1985-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS:A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000468
更新日期:2018-08-01 00:00:00
abstract::Magnetic resonance spectroscopy (MRS) has been most extensively applied to the study of animal models and not humans. The major reason for this extensive animal research is due to the nature of the early magnetic resonance high-field magnets, which only permitted the study of isolated cells, tissues, or small animals....
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-198912000-00004
更新日期:1989-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:The purpose of this study was to investigate the feasibility, efficacy, and safety of ultrasound-guided percutaneous cryotherapy of stage T1 breast cancers. MATERIALS AND METHODS:Thirty patients with biopsy-confirmed breast cancers with tumor diameters of 15 mm or smaller (range, 5-15 mm; media...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000166935.56971.ff
更新日期:2005-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the for...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/RLI.0000000000000507
更新日期:2018-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The objective of the present study was to compare the data regarding the ability of real-time myocardial contrast echocardiography (MCE) to assess altered myocardial blood flow produced by graded coronary stenoses between open- and closed-chest canine models. MATERIALS AND METHODS:Three grades...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200301000-00006
更新日期:2003-01-01 00:00:00
abstract::The sonographic appearance of kidneys in patients presenting with acute renal failure due to hemolytic-uremic syndrome (HUS) was evaluated and compared with that in an age-matched control series. In nine patients with HUS, the renal cortex was typically hyperechogenic and the renal pyramids appeared sonolucent. The re...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198607000-00006
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000218
更新日期:2016-03-01 00:00:00