Low-osmolality contrast media-induced ventricular fibrillation.

Abstract:

:We evaluated the incidence of ventricular fibrillation with low-osmolality contrast media by right coronary arteriography in eleven adult mongrel dogs. Following insertion of the catheter into the right coronary artery, a test solution was infused for 25 seconds (total 11 mL) or until fibrillation occurred. The test solutions included 20% mannitol, ioxaglate, iopamidol, iotrolan, and sodium iopamidol, which contained 150 mEq/L sodium in solution. The incidences of ventricular fibrillation were 0% with iotrolan, 8.3% with sodium iopamidol, 10% with ioxaglate, and 100% with iopamidol and mannitol. These observations suggest that the absence of sodium ions is a critical factor in fibrillation, even in low-osmolality contrast media. The fact that iotrolan had the least arrhythmogenic property may be attributed to the 8 mEq/L of sodium ions in that agent.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Hayakawa K,Yamashita K

doi

10.1097/00004424-198904000-00008

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

298-301

issue

4

eissn

0020-9996

issn

1536-0210

journal_volume

24

pub_type

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