Abstract:
OBJECTIVE:There is little published information regarding the efficacy of paclitaxel-coated balloon catheters except for the iopromide-containing formulation, and less is known about the kind of toxicity at overdose. The aim of our study was to assess 2 different paclitaxel matrix formulations on angioplasty balloon catheters in vitro, with respect to pharmacokinetics, and efficacy and tolerance to determine the minimum effective dose and local toxicity at extremely high dose which is only achieved in experimental studies. METHODS AND MATERIALS:Adherence of coatings was tested in vitro in dry state and during passage through hemostatic valves, guiding catheters, and blood. Drug release, transfer to the vessel wall during coronary angioplasty, inhibition of neointimal proliferation, and tolerance were investigated in swine. Efficacy and tolerance of balloons were examined for doses ranging from 1 to 9 μg/mm2 and 3 overlapping applications of balloons coated with 3 times the regular dose of 3 μg/mm2. Paclitaxel concentrations were determined by high performance liquid chromatography, efficacy and tolerance by vital signs, clinical observation, quantitative coronary angiography, and histomorphometry 4 weeks after implanting premounted bare stents in coronary arteries applying 1:1.2 overstretch. RESULTS:Under worst-case conditions, drug loss on the way through the guiding catheter and blood was in the range of 30%. After inflation of balloons coated with the clinically tested dose of 3 μg/mm2 in a coronary artery about 10% of drug remained on balloons, 20% to 30% was taken up into the vessel wall (∼200 μg). Neointimal area on cross sections was 6.8 ± 2.2 mm2 (uncoated control); 3.1 ± 1.1 mm2 (iopromide-matrix) and 3.0 ± 0.5 mm2 (urea-matrix) at 1 μg/mm2; 2.0 ± 0.4 mm2 versus 1.7 ± 1.1 mm2 at 3 μg/mm2 with no further decrease at higher doses. Thrombotic occlusions were observed in 3 of 15 vessel segments treated with overlapping inflations of 3 high-dose balloons but without any signs of aneurysms. CONCLUSION:In the animal model, 2 paclitaxel matrix formulations were similar in respect of uptake in the vessel wall, and effective already at a dose of 1 μg/mm2. Except thrombotic events for the intentionally excessive dose, paclitaxel-coated balloons were well tolerated in the animal model.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Kelsch B,Scheller B,Biedermann M,Clever YP,Schaffner S,Mahnkopf D,Speck U,Cremers Bdoi
10.1097/RLI.0b013e31820577dfsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
255-63issue
4eissn
0020-9996issn
1536-0210journal_volume
46pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The authors studied the effect of contrast dose, use of magnetization transfer (MT), and temporal delay on the visualization of contrast enhancement with gadoteridol (Gd HP-DO3A) in a canine brain abscess model. METHODS:Alpha streptococcus brain abscesses were studied in five dogs at 1.5 tesla...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199503000-00001
更新日期:1995-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance microscopy (MRM) has evolved from a technical curiosity to a tool with which researchers can study important disease models. But MRM is not simply an extension of clinical magnetic resonance imaging. In this article, the unique adaptations of MRM required in the study of caro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199409000-00004
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS:Bacterial magnetic nanopa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000255832.44443.e7
更新日期:2007-04-01 00:00:00
abstract::Proposed causes of renal papillary necrosis (RPN) include tubular toxicity due to hyperconcentration of toxins in the renal medulla and vasoconstriction of medullary vessels with ischemic necrosis. The authors studied these mechanisms in bromoethylamine hydrobromide-induced RPN in rats by microvascular and tubular mic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198103000-00006
更新日期:1981-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Hepatocellular carcinomas (HCCs) usually consist of components of different histologic grade. Using surgically resected specimens, the authors obtained high-resolution magnetic resonance (MR) images and studied the relationship between histologic grade of HCCs and MR signal intensity. METHOD:I...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199308000-00007
更新日期:1993-08-01 00:00:00
abstract::Advances in the field of magnetic resonance (MR) as it pertains to clinical diagnostic radiology are examined in this review on the basis of publications in Investigative Radiology over the past 2 years (2005-2006). The articles published during that timeframe are discussed, organizationally wise, by anatomic region w...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/01.rli.0000250461.03245.5c
更新日期:2006-12-01 00:00:00
abstract::The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199108000-00009
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the impact of a novel iterative denoising and image enhancement technique in T1-weighted precontrast and postcontrast volume-interpolated breath-hold examination (VIBE) of the abdomen on image quality, noise levels, and diagnostic confidence without change of acquisit...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000746
更新日期:2020-11-18 00:00:00
abstract:RATIONALE AND OBJECTIVES:The capability of an indirect computed tomographic lymphography (CT-LG) using a nonionic monometric contrast medium iopamidol for visualizing breast lymphatic pathways was preliminarily tested. MATERIALS AND METHODS:In 10 female dogs, a total of 0.5 and 1 mL of undiluted iopamidol was injected...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200302000-00002
更新日期:2003-02-01 00:00:00
abstract::A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was great...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-198411001-00012
更新日期:1984-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare electron beam tomography (EBT) with MR imaging (MRI) for detection of restenosis after coronary angioplasty (PTCA). METHODS:One hundred eighteen patients after PTCA were investigated. By EBT, 50 axial images were acquired (3-mm slice thickness, 120-160 mL radiographic contrast agent...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200207000-00005
更新日期:2002-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Because of the complex relationships between the dynamic three-dimensional cardiac surface shape and its projected image, errors arise with the use of two-dimensional silhouettes to measure displacements of the heart. The character and frequency of such errors are examined. METHODS:A high-prec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00004
更新日期:1994-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.RLI.0000068620.17569.83
更新日期:2003-07-01 00:00:00
abstract::Proton magnetic resonance (MR) spectroscopy with homonuclear editing was used to assess lactate accumulation in ischemic and anoxic hearts perfused according to the Langendorff method. An increase in the lactate signal was observed after 5 minutes of ischemia and after 10 to 20 minutes of anoxia. This study demonstrat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198708000-00004
更新日期:1987-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate postmortem metabolic and morphologic alterations in the dog brain thalamus and to contribute diagnostic aids in medicolegal science. METHODS:A homogeneous group of 17 dogs was used for in vivo 1H magnetic resonance (MR) spectroscopy and electron microscopic studies, which were p...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199505000-00001
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:In late December 2019, an outbreak of coronavirus disease (COVID-19) in Wuhan, China was caused by a novel coronavirus, newly named severe acute respiratory syndrome coronavirus 2. We aimed to quantify the severity of COVID-19 infection on high-resolution chest computed tomography (CT) and to determine its r...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000674
更新日期:2020-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance imaging (MRI) techniques seem to be very promising for 3D dosimetry studies, but long imaging acquisition time limits their use. A new fast T1 mapping protocol, easy to implement on a conventional MR imager, has been used to determine dose distributions on Fricke gels. METHO...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199903000-00014
更新日期:1999-03-01 00:00:00
abstract::The microangiographic anatomy of the cat's eye is presented. The characteristic vascular pattern of each of the three distinct circulations, retinal choroidal, and ciliary is described and illustrated. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197501000-00007
更新日期:1975-01-01 00:00:00
abstract::We have examined the metabolic behavior of several triiodobenzoic acid derivatives because of the observed mutagenicity and cytotoxicity of 3-amino-5-acetamido-2,4,6-triiodobenzoate (I) and 3,5-diamino-2,4,6-triiodobenzoate (II). Measurements were facilitated using iodine-131 (131I)-labeled compounds. Drug retention i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198211000-00007
更新日期:1982-11-01 00:00:00
abstract::Low-dose transaxial tomography is a technique that can produce cross-sectional images of the hips and femurs in children to permit calculation of the angle of femoral anteversion. Transaxial tomography was compared with computed tomography in terms of measured radiation dose and image quality. Transaxial tomography wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study assesses the ability of a cardiac-gated phase-contrast magnetic resonance imaging (MRI) technique to measure renal blood flow (RBF) noninvasively in humans. METHODS:In nine normal volunteers, total RBF in the renal arteries and in the left renal vein was estimated by MRI and correla...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199206000-00012
更新日期:1992-06-01 00:00:00
abstract::The association of GE Medical Systems and the AUR represents a unique collaboration between academic radiology and industry that bears important potential for elevating the quality of clinical research in radiology and developing a cadre of high-quality radiologist researchers for the future. The establishment of the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199305000-00001
更新日期:1993-05-01 00:00:00
abstract::A series of 5-hydroxyacylamino-2,4,6-triiodo-N,N'-hydroxy-alkyl-isophtalamides was prepared in order to study the structural requirements for high water solubility and low toxicity. Among the amides substituted by 2-hydroxyethyl; 2,3-dihydroxypropyl; 1,3-dihydroxypropyl-; and 1,1-dihydroxy-methyl-2-oxyethyl- groups, t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00065
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000064
更新日期:2014-10-01 00:00:00
abstract::Thoracic metastases from squamous carcinoma and adenocarcinoma of the cervix were studied by reviewing 245 consecutive cases to describe comparative incidence, natural history, and radiographic patterns. The incidence of chest metastases was higher for adenocarcinoma (20%) than for squamous carcinoma (4%). Few patient...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198003000-00004
更新日期:1980-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The object of this study was to determine by flow cytometry the cellular and DNA content of the washings of core biopsy samples and needles obtained during stereotactic core biopsies of clinically occult suspicious lesions. METHODS:Fourteen-gauge core multipass biopsy inner-needle saline washi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199801000-00008
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations. MATERIALS AND METHODS:A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic re...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000554
更新日期:2019-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diabetic patients frequently suffer contrast media-induced nephropathy. Hyperglycemia in diabetes mellitus causes gradual deterioration of glomerular mesangial cells (MCs) in the kidney. In this study, the authors investigated the response of rat MCs cultured in high-glucose medium to diatrizoa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200107000-00001
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:Dynamic contrast-enhanced imaging allows assessing functional information in addition to morphology using various modalities. Several applications have been established in clinical practice; however, there is no standard with respect to injection protocols or postprocessing algorithms. The purpose of this st...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318250a72c
更新日期:2012-08-01 00:00:00